Endometrial cancer medical therapy: Difference between revisions
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:* A total [[hysterectomy]] and bilateral [[salpingo-oophorectomy]] should be done. | :* A total [[hysterectomy]] and bilateral [[salpingo-oophorectomy]] should be done. | ||
:* Selected pelvic lymph nodes may be removed. If they are negative, no postoperative treatment is indicated. Postoperative treatment with a vaginal cylinder is advocated by some clinicians. | :* Selected pelvic lymph nodes may be removed. If they are negative, no postoperative treatment is indicated. Postoperative treatment with a vaginal cylinder is advocated by some clinicians. | ||
'''Stage II Endometrial Cancer''' | '''Stage II Endometrial Cancer'''<ref> Endometrial Cancer Treatment. National Cancer Institute http://www.cancer.gov/types/uterine/hp/endometrial-treatment-pdq#section/_45 Accessed on September, 7 2015</ref> | ||
* Standard treatment options: | * Standard treatment options: | ||
:* If cervical involvement is documented, options include radical hysterectomy, bilateral salpingo-oophorectomy, and pelvic and para-aortic [[lymph node]] dissection. | :* If cervical involvement is documented, options include radical hysterectomy, bilateral salpingo-oophorectomy, and pelvic and para-aortic [[lymph node]] dissection. | ||
:* If the [[cervix]] is clinically uninvolved but extension to the cervix is documented on postoperative pathology, radiation therapy should be considered. | :* If the [[cervix]] is clinically uninvolved but extension to the cervix is documented on postoperative pathology, radiation therapy should be considered. | ||
'''Stage III Endometrial cancer''' | '''Stage III Endometrial cancer'''<ref> Endometrial Cancer Treatment. National Cancer Institute http://www.cancer.gov/types/uterine/hp/endometrial-treatment-pdq#section/_54 Accessed on September, 7 2015</ref> | ||
* Standard treatment options: | * Standard treatment options: | ||
:* Patients with stage III endometrial cancer are treated with [[surgery]], followed by [[chemotherapy]], or [[radiation therapy]], or both. | :* Patients with stage III endometrial cancer are treated with [[surgery]], followed by [[chemotherapy]], or [[radiation therapy]], or both. | ||
:* Patients with inoperable disease caused by tumor that extends to the pelvic wall may be treated with a combination of chemotherapy and radiation therapy. The usual approach is to use a combination of intracavitary radiation therapy and external-beam radiation therapy. | :* Patients with inoperable disease caused by tumor that extends to the pelvic wall may be treated with a combination of chemotherapy and radiation therapy. The usual approach is to use a combination of intracavitary radiation therapy and external-beam radiation therapy. | ||
'''Stage IV Endometrial cancer''' | '''Stage IV Endometrial cancer'''<ref> Endometrial Cancer Treatment. National Cancer Institute http://www.cancer.gov/types/uterine/hp/endometrial-treatment-pdq#section/_59 Accessed on September, 7 2015</ref> | ||
* Standard treatment options: | * Standard treatment options: | ||
:* Treatment of patients with stage IV endometrial cancer is dictated by the site of metastatic disease and symptoms related to disease sites. For bulky pelvic disease, radiation therapy consisting of a combination of intracavitary and external-beam radiation therapy is used. | :* Treatment of patients with stage IV endometrial cancer is dictated by the site of metastatic disease and symptoms related to disease sites. For bulky pelvic disease, radiation therapy consisting of a combination of intracavitary and external-beam radiation therapy is used. | ||
Revision as of 13:23, 28 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
The optimal therapy for endometrial cancer depends on the stage at diagnosis. A combination of chemotherapy and radiation therapy is indicated in Stages(IIIB- IV).
Medical Therapy
Stage I Endometrial Cancer[1]
- Standard treatment options:
- A total hysterectomy and bilateral salpingo-oophorectomy should be done.
- Selected pelvic lymph nodes may be removed. If they are negative, no postoperative treatment is indicated. Postoperative treatment with a vaginal cylinder is advocated by some clinicians.
Stage II Endometrial Cancer[2]
- Standard treatment options:
- If cervical involvement is documented, options include radical hysterectomy, bilateral salpingo-oophorectomy, and pelvic and para-aortic lymph node dissection.
- If the cervix is clinically uninvolved but extension to the cervix is documented on postoperative pathology, radiation therapy should be considered.
Stage III Endometrial cancer[3]
- Standard treatment options:
- Patients with stage III endometrial cancer are treated with surgery, followed by chemotherapy, or radiation therapy, or both.
- Patients with inoperable disease caused by tumor that extends to the pelvic wall may be treated with a combination of chemotherapy and radiation therapy. The usual approach is to use a combination of intracavitary radiation therapy and external-beam radiation therapy.
Stage IV Endometrial cancer[4]
- Standard treatment options:
- Treatment of patients with stage IV endometrial cancer is dictated by the site of metastatic disease and symptoms related to disease sites. For bulky pelvic disease, radiation therapy consisting of a combination of intracavitary and external-beam radiation therapy is used.
References
- ↑ Endometrial Cancer Treatment. National Cancer Institute http://www.cancer.gov/types/uterine/hp/endometrial-treatment-pdq#section/_40 Accessed on September, 7 2015
- ↑ Endometrial Cancer Treatment. National Cancer Institute http://www.cancer.gov/types/uterine/hp/endometrial-treatment-pdq#section/_45 Accessed on September, 7 2015
- ↑ Endometrial Cancer Treatment. National Cancer Institute http://www.cancer.gov/types/uterine/hp/endometrial-treatment-pdq#section/_54 Accessed on September, 7 2015
- ↑ Endometrial Cancer Treatment. National Cancer Institute http://www.cancer.gov/types/uterine/hp/endometrial-treatment-pdq#section/_59 Accessed on September, 7 2015