Glioblastoma multiforme medical therapy: Difference between revisions
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==Medical Therapy== | ==Medical Therapy== | ||
The predominant therapy for glioblastoma multiforme is [[surgical resection]]. Adjunctive [[chemotherapy]] and [[radiation]] may be required.<ref name=ddd>Treatment of glioblastoma multiforme. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/glioblastoma</ref> | The predominant therapy for glioblastoma multiforme is [[surgical resection]]. Adjunctive [[chemotherapy]] and [[radiation]] may be required.<ref name=ddd>Treatment of glioblastoma multiforme. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/glioblastoma</ref><ref name="pmid25468225">{{cite journal| author=Barani IJ, Larson DA| title=Radiation therapy of glioblastoma. | journal=Cancer Treat Res | year= 2015 | volume= 163 | issue= | pages= 49-73 | pmid=25468225 | doi=10.1007/978-3-319-12048-5_4 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25468225 }} </ref> | ||
===Radiotherapy=== | ===Radiotherapy=== | ||
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*Radiotherapy may not cure the cancer, but can control the tumor and delay recurrence. | *Radiotherapy may not cure the cancer, but can control the tumor and delay recurrence. | ||
*Targeted three-dimensional conformal [[radiotherapy]] is preferred to whole brain radiotherapy. | *Targeted three-dimensional conformal [[radiotherapy]] is preferred to whole brain radiotherapy. | ||
*Total [[radiation]] dose of | *Total [[radiation]] dose of 5,000-6,000 cGy has been found to be optimal for treatment.<ref name="pmid25468225">{{cite journal| author=Barani IJ, Larson DA| title=Radiation therapy of glioblastoma. | journal=Cancer Treat Res | year= 2015 | volume= 163 | issue= | pages= 49-73 | pmid=25468225 | doi=10.1007/978-3-319-12048-5_4 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25468225 }} </ref> | ||
===Chemotherapy=== | ===Chemotherapy=== | ||
Revision as of 21:38, 28 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
The predominant therapy for glioblastoma multiforme is surgical resection. Adjunctive chemotherapy and radiation may be required.[1] Supportive therapy for glioblastoma multiforme includes anticonvulsants and corticosteroids.
Medical Therapy
The predominant therapy for glioblastoma multiforme is surgical resection. Adjunctive chemotherapy and radiation may be required.[1][2]
Radiotherapy
- Post-operative radiotherapy is recommended among all patients who develop glioblastoma multiforme.
- Adjuvant radiotherapy can reduce the tumor size to 107 cells.
- Radiotherapy may not cure the cancer, but can control the tumor and delay recurrence.
- Targeted three-dimensional conformal radiotherapy is preferred to whole brain radiotherapy.
- Total radiation dose of 5,000-6,000 cGy has been found to be optimal for treatment.[2]
Chemotherapy
- Chemotherapy is indicated as adjuvant therapy for glioblastoma multiforme.
- Temozolomide (Temodar) is the preferred drug for the treatment of glioblastoma multiforme.
- Other chemotherapeutic drugs that may be used for the treatment of glioblastoma multiforme include:
Supportive treatment
Supportive therapy for glioblastoma multiforme includes anticonvulsants and corticosteroids, which focuses on relieving symptoms and improving the patient’s neurologic function.
- Anticonvulsants are administered to the patients who have a seizure. Phenytoin given concurrently with radiation may have serious skin reactions such as erythema multiforme and Stevens-Johnson syndrome.
- Corticosteroids, usually dexamethasone given 4-10 mg every 4-6 h, can reduce peritumoral edema, diminish mass effect, and lower intracranial pressure with a decrease in headache or drowsiness.
References
- ↑ 1.0 1.1 Treatment of glioblastoma multiforme. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/glioblastoma
- ↑ 2.0 2.1 Barani IJ, Larson DA (2015). "Radiation therapy of glioblastoma". Cancer Treat Res. 163: 49–73. doi:10.1007/978-3-319-12048-5_4. PMID 25468225.