T-cell prolymphocytic leukemia medical therapy

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Carlos A Lopez, M.D. [2]

Medical Therapy

T-cell prolymphocytic leukemia responds better when combinations of chemotherapy drugs are used. Some combinations that may be used are:

• CVP – Cyclophosphamide, vincristine and prednisone.

• CHOP – Cyclophosphamide, doxorubicin, vincristine and prednisone.

Other chemotherapy drugs (purine analogues) are often used to treat T-cell prolymphocytic leukemia are:

• Fludarabine
• Cladribine
• Pentostatin

Biological therapy

Monoclonal antibodies are a type of biological therapy that has been effective in treating certain types of leukemias. These drugs may be used alone or in combination with chemotherapy to treat prolymphocytic leukemia.

• Alemtuzumab seems to be particularly effective in treating T-cell-prolymphocytic leukemia. It may be used in people whose lymphoma is no longer responding to chemotherapy drugs like fludarabine.