Insulinoma pathophysiology

Insulinoma Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]

Pathophysiology

• Insulinoma can occur in association with inherited syndrome, such as multiple endocrine neoplasia type 1 or sporadic.

• Multiple endocrine neoplasia type 1 is an autosomal dominant disorder caused by alterations of the MEN1 gene located at chromosomal region 11q13.
• Approximately 10% of insulinomas are multiple and 10% malignant.

<gallery widths=200px> Pancreatic insulinoma Histology 1.JPG|Histopathology of pancreatic endocrine tumor (insulinoma). H&E stain<ref?Neuroendocrine tumour of the pancreas. Libre Pathology. http://librepathology.org/wiki/index.php/Neuroendocrine_tumour_of_the_pancreas</ref>

References

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