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==Pathophysiology==
==Pathophysiology==
*Insulinoma can occur in association with inherited syndrome, such as [[multiple endocrine neoplasia type 1]] or sporadic.<ref name="pmid3498768">{{cite journal| author=Murray PD, McKenzie DT, Swain SL, Kagnoff MF| title=Interleukin 5 and interleukin 4 produced by Peyer's patch T cells selectively enhance immunoglobulin A expression. | journal=J Immunol | year= 1987 | volume= 139 | issue= 8 | pages= 2669-74 | pmid=3498768 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3498768  }} </ref>
==Genetics==
*Insulinoma can occur in association with inherited syndrome, such as [[multiple endocrine neoplasia type 1]] [[von Hippel-Landau syndrome]] or sporadic.<ref name="pmid3498768">{{cite journal| author=Murray PD, McKenzie DT, Swain SL, Kagnoff MF| title=Interleukin 5 and interleukin 4 produced by Peyer's patch T cells selectively enhance immunoglobulin A expression. | journal=J Immunol | year= 1987 | volume= 139 | issue= 8 | pages= 2669-74 | pmid=3498768 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3498768  }} </ref>


*Multiple endocrine neoplasia type 1 is an autosomal dominant disorder caused by alterations of the ''MEN1'' gene located at chromosomal region 11q13.
*Multiple endocrine neoplasia type 1 is an autosomal dominant disorder caused by alterations of the ''MEN1'' gene located at chromosomal region 11q13.
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==Microscopic Pathology==
<gallery widths=200px>
<gallery widths=200px>
Pancreatic insulinoma Histology 1.JPG|Histopathology of pancreatic endocrine tumor (insulinoma). H&E stain<ref name=aaa> Neuroendocrine tumour of the pancreas. Libre Pathology. http://librepathology.org/wiki/index.php/Neuroendocrine_tumour_of_the_pancreas</ref>
Pancreatic insulinoma Histology 1.JPG|Histopathology of pancreatic endocrine tumor (insulinoma). H&E stain<ref name=aaa> Neuroendocrine tumour of the pancreas. Libre Pathology. http://librepathology.org/wiki/index.php/Neuroendocrine_tumour_of_the_pancreas</ref>

Revision as of 18:38, 1 October 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]

Overview

Pathophysiology

Genetics

  • Multiple endocrine neoplasia type 1 is an autosomal dominant disorder caused by alterations of the MEN1 gene located at chromosomal region 11q13.
  • Approximately 10% of insulinomas are multiple and 10% malignant.[2]


Microscopic Pathology

  • Histopathology of pancreatic endocrine tumor (insulinoma). H&E stain[3]
    Histopathology of pancreatic endocrine tumor (insulinoma). H&E stain[3]
  • Histopathology of pancreatic endocrine tumor (insulinoma)[3]
    Histopathology of pancreatic endocrine tumor (insulinoma)[3]
  • Histopathology of pancreatic endocrine tumor (insulinoma). Chromogranin A immunostain[3]
    Histopathology of pancreatic endocrine tumor (insulinoma). Chromogranin A immunostain[3]
  • Histopathology of pancreatic endocrine tumor (insulinoma). Insulin immunostain[3]
    Histopathology of pancreatic endocrine tumor (insulinoma). Insulin immunostain[3]

References

  1. ↑ Murray PD, McKenzie DT, Swain SL, Kagnoff MF (1987). "Interleukin 5 and interleukin 4 produced by Peyer's patch T cells selectively enhance immunoglobulin A expression". J Immunol. 139 (8): 2669–74. PMID 3498768.
  2. ↑ Insulinoma. Dr Yuranga Weerakkody and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/insulinoma
  3. ↑ 3.0 3.1 3.2 3.3 Neuroendocrine tumour of the pancreas. Libre Pathology. http://librepathology.org/wiki/index.php/Neuroendocrine_tumour_of_the_pancreas


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