Gliomatosis cerebri other imaging findings: Difference between revisions
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===1. MR Spectroscopy=== | ===1. MR Spectroscopy=== | ||
[[In vivo magnetic resonance spectroscopy|MR spectroscopy]] may be helpful in the diagnosis of gliomatosis cerebri. Findings on [[In vivo magnetic resonance spectroscopy|MR spectroscopy]] suggestive of gliomatosis cerebri include:<ref name=aaa>Radiographic features of gliomatosis cerebri. Dr Henry Knipe and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/gliomatosis-cerebri</ref><ref name="pmid20334921">{{cite journal| author=Desclée P, Rommel D, Hernalsteen D, Godfraind C, de Coene B, Cosnard G| title=Gliomatosis cerebri, imaging findings of 12 cases. | journal=J Neuroradiol | year= 2010 | volume= 37 | issue= 3 | pages= 148-58 | pmid=20334921 | doi=10.1016/j.neurad.2009.12.001 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20334921 }} </ref> | |||
*Decreased [[N-Acetylaspartic acid|NAA]]/[[creatine]] ratio | *Decreased [[N-Acetylaspartic acid|NAA]]/[[creatine]] ratio | ||
*Elevated [[choline]]/[[creatine]] ratio | *Elevated [[choline]]/[[creatine]] ratio | ||
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===2. MR Perfusion=== | ===2. MR Perfusion=== | ||
[[perfusion weighted imaging|MR perfusion]] may be helpful in the diagnosis of gliomatosis cerebri. Findings on [[perfusion weighted imaging|MR perfusion]] suggestive of gliomatosis cerebri include:<ref name=aaa>Radiographic features of gliomatosis cerebri. Dr Henry Knipe and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/gliomatosis-cerebri</ref> | |||
*Low/normal relative cerebral blood flow (no vascular [[hyperplasia]]) | *Low/normal relative cerebral blood flow (no vascular [[hyperplasia]]) | ||
===3. PET=== | ===3. PET=== | ||
[[PET scan]] may be helpful in the diagnosis of gliomatosis cerebri. Findings on [[PET scan]] suggestive of gliomatosis cerebri include:<ref name=aaa>Radiographic features of gliomatosis cerebri. Dr Henry Knipe and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/gliomatosis-cerebri</ref><ref name="pmid22740882">{{cite journal| author=Rajz GG, Nass D, Talianski E, Pfeffer R, Spiegelmann R, Cohen ZR| title=Presentation patterns and outcome of gliomatosis cerebri. | journal=Oncol Lett | year= 2012 | volume= 3 | issue= 1 | pages= 209-213 | pmid=22740882 | doi=10.3892/ol.2011.445 | pmc=PMC3362440 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22740882 }} </ref> | |||
*[[PET|F-18 FDG PET]] images show markedly decreased accumulation of [[Florbetapir (18F)|[18F]-fluorodeoxyglucose]] ([[glucose metabolism|glucose hypometabolism]]). | *[[PET|F-18 FDG PET]] images show markedly decreased accumulation of [[Florbetapir (18F)|[18F]-fluorodeoxyglucose]] ([[glucose metabolism|glucose hypometabolism]]). | ||
*[[PET|C-11 methionine PET]] images show [[hypermetabolism]]. | *[[PET|C-11 methionine PET]] images show [[hypermetabolism]]. |
Revision as of 18:15, 5 October 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Other imaging studies for gliomatosis cerebri include MR spectroscopy (decreased NAA/creatine ratio and elevated choline/creatine ratio, choline/NAA ratio, and myoinositol), MR perfusion (low/normal relative cerebral blood flow), PET scan (markedly decreased accumulation of [18F]-fluorodeoxyglucose on F-18 FDG PET, hypermetabolism on C-11 methionine PET, and marked increase in cerebral blood flow on 15(O)-water PET), and bone scan (metastasis to bones).[1][2][3][4]
Other Imaging Findings
Other imaging studies for gliomatosis cerebri include MR spectroscopy (decreased NAA/creatine ratio and elevated choline/creatine ratio, choline/NAA ratio, and myoinositol), MR perfusion (low/normal relative cerebral blood flow), PET scan (markedly decreased accumulation of [18F]-fluorodeoxyglucose on F-18 FDG PET, hypermetabolism on C-11 methionine PET, and marked increase in cerebral blood flow on 15(O)-water PET), and bone scan (metastasis to bones).[1][2][3]
1. MR Spectroscopy
MR spectroscopy may be helpful in the diagnosis of gliomatosis cerebri. Findings on MR spectroscopy suggestive of gliomatosis cerebri include:[1][3]
- Decreased NAA/creatine ratio
- Elevated choline/creatine ratio
- Elevated choline/NAA ratio
- Elevated myoinositol
2. MR Perfusion
MR perfusion may be helpful in the diagnosis of gliomatosis cerebri. Findings on MR perfusion suggestive of gliomatosis cerebri include:[1]
- Low/normal relative cerebral blood flow (no vascular hyperplasia)
3. PET
PET scan may be helpful in the diagnosis of gliomatosis cerebri. Findings on PET scan suggestive of gliomatosis cerebri include:[1][2]
- F-18 FDG PET images show markedly decreased accumulation of [18F]-fluorodeoxyglucose (glucose hypometabolism).
- C-11 methionine PET images show hypermetabolism.
- 15(O)-water PET images show a marked increase in cerebral blood flow in gliomatosis cerebri lesions.
4. Bone Scan
- Most malignant gliomas get metastasized to the bones via the hematogenous spread.[4]
- Bone scan may be performed to detect metastases of gliomatosis cerebri to bones.
References
- ↑ 1.0 1.1 1.2 1.3 1.4 Radiographic features of gliomatosis cerebri. Dr Henry Knipe and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/gliomatosis-cerebri
- ↑ 2.0 2.1 2.2 Rajz GG, Nass D, Talianski E, Pfeffer R, Spiegelmann R, Cohen ZR (2012). "Presentation patterns and outcome of gliomatosis cerebri". Oncol Lett. 3 (1): 209–213. doi:10.3892/ol.2011.445. PMC 3362440. PMID 22740882.
- ↑ 3.0 3.1 3.2 Desclée P, Rommel D, Hernalsteen D, Godfraind C, de Coene B, Cosnard G (2010). "Gliomatosis cerebri, imaging findings of 12 cases". J Neuroradiol. 37 (3): 148–58. doi:10.1016/j.neurad.2009.12.001. PMID 20334921.
- ↑ 4.0 4.1 Beauchesne P (2011). "Extra-neural metastases of malignant gliomas: myth or reality?". Cancers (Basel). 3 (1): 461–77. doi:10.3390/cancers3010461. PMC 3756372. PMID 24212625.