Insulinoma medical therapy: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
|||
| Line 7: | Line 7: | ||
==Non-surgical Options== | ==Non-surgical Options== | ||
*Octreotide | *Octreotide<ref name="pmid23430217">{{cite journal| author=Okabayashi T, Shima Y, Sumiyoshi T, Kozuki A, Ito S, Ogawa Y et al.| title=Diagnosis and management of insulinoma. | journal=World J Gastroenterol | year= 2013 | volume= 19 | issue= 6 | pages= 829-37 | pmid=23430217 | doi=10.3748/wjg.v19.i6.829 | pmc=PMC3574879 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23430217 }} </ref> | ||
*Endoscopic ultrasound guided alcohol ablation | *Endoscopic ultrasound guided alcohol ablation<ref name="pmid23430217">{{cite journal| author=Okabayashi T, Shima Y, Sumiyoshi T, Kozuki A, Ito S, Ogawa Y et al.| title=Diagnosis and management of insulinoma. | journal=World J Gastroenterol | year= 2013 | volume= 19 | issue= 6 | pages= 829-37 | pmid=23430217 | doi=10.3748/wjg.v19.i6.829 | pmc=PMC3574879 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23430217 }} </ref> | ||
*Radiofrequency ablation (RFA) | *Radiofrequency ablation (RFA)<ref name="pmid23430217">{{cite journal| author=Okabayashi T, Shima Y, Sumiyoshi T, Kozuki A, Ito S, Ogawa Y et al.| title=Diagnosis and management of insulinoma. | journal=World J Gastroenterol | year= 2013 | volume= 19 | issue= 6 | pages= 829-37 | pmid=23430217 | doi=10.3748/wjg.v19.i6.829 | pmc=PMC3574879 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23430217 }} </ref> | ||
*Embolization | *Embolization<ref name="pmid23430217">{{cite journal| author=Okabayashi T, Shima Y, Sumiyoshi T, Kozuki A, Ito S, Ogawa Y et al.| title=Diagnosis and management of insulinoma. | journal=World J Gastroenterol | year= 2013 | volume= 19 | issue= 6 | pages= 829-37 | pmid=23430217 | doi=10.3748/wjg.v19.i6.829 | pmc=PMC3574879 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23430217 }} </ref> | ||
*Diazoxide | *Diazoxide | ||
| Line 19: | Line 19: | ||
Medications such as [[diazoxide]] and [[somatostatin]] can be used to block the release of insulin for patients who are not surgical candidates or who otherwise have inoperable tumours. | Medications such as [[diazoxide]] and [[somatostatin]] can be used to block the release of insulin for patients who are not surgical candidates or who otherwise have inoperable tumours. | ||
[[Streptozotocin]] is used in [[islet cell carcinoma]]s which produce excessive insulin. Combination [[chemotherapy]] is used: either [[doxorubicin]] + streptozotocin, or [[fluorouracil]] + streptotozocin in patients where doxorubicin is contraindicated.<ref>[http://www.cancer.gov/cancertopics/pdq/treatment/isletcell/HealthProfessional/page6]</ref> | [[Streptozotocin]] is used in [[islet cell carcinoma]]s which produce excessive insulin. Combination [[chemotherapy]] is used: either [[doxorubicin]] + streptozotocin, or [[fluorouracil]] + streptotozocin in patients where doxorubicin is contraindicated.<ref>[http://www.cancer.gov/cancertopics/pdq/treatment/isletcell/HealthProfessional/page6]</ref> | ||
In metastasizing tumours with intrahepatic growth, [[hepatic artery|hepatic arterial]] occlusion or [[embolization]] can be used. <ref>[http://www.nci.nih.gov/cancertopics/pdq/treatment/isletcell/Patient/page5]</ref> | In metastasizing tumours with intrahepatic growth, [[hepatic artery|hepatic arterial]] occlusion or [[embolization]] can be used. <ref>[http://www.nci.nih.gov/cancertopics/pdq/treatment/isletcell/Patient/page5]</ref> | ||
Revision as of 17:48, 7 October 2015
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [3]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [4]
|
Insulinoma Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Insulinoma medical therapy On the Web |
|
American Roentgen Ray Society Images of Insulinoma medical therapy |
|
Risk calculators and risk factors for Insulinoma medical therapy |
Overview
Non-surgical Options
- Octreotide[1]
- Endoscopic ultrasound guided alcohol ablation[1]
- Radiofrequency ablation (RFA)[1]
- Embolization[1]
- Diazoxide
- Chemotherapy
Medications such as diazoxide and somatostatin can be used to block the release of insulin for patients who are not surgical candidates or who otherwise have inoperable tumours.
Streptozotocin is used in islet cell carcinomas which produce excessive insulin. Combination chemotherapy is used: either doxorubicin + streptozotocin, or fluorouracil + streptotozocin in patients where doxorubicin is contraindicated.[2]
In metastasizing tumours with intrahepatic growth, hepatic arterial occlusion or embolization can be used. [3]