Hypopharyngeal cancer pathophysiology: Difference between revisions
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{{CMG}} {{AE}}{{Faizan}} | {{CMG}} {{AE}}{{Faizan}} | ||
==Overview== | ==Overview== | ||
Genes involved in the pathogenesis of hypopharyngeal cancer include ''p16'', ''NOTCH1'', | Genes involved in the pathogenesis of hypopharyngeal cancer include ''[[P16 (gene)|p16]]'', ''NOTCH1'', ''cyclin D1'', and ''[[TP53]]''. Hypopharyngeal cancer is associated with sideropaenic dysphagia and Paterson Brown Kelly syndrome.On gross pathology, flattened plaques, mucosal ulceration, and raised margins of the lesion are characteristic findings of hypopharyngeal cancer. On microscopic histopathological analysis, [[spindle cell]]s, basaloid cells, and nuclear atypia are characteristic findings of hypopharyngeal cancer.<ref name="pmid12560383">{{cite journal| author=Helliwell TR| title=acp Best Practice No 169. Evidence based pathology: squamous carcinoma of the hypopharynx. | journal=J Clin Pathol | year= 2003 | volume= 56 | issue= 2 | pages= 81-5 | pmid=12560383 | doi= | pmc=PMC1769882 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12560383 }} </ref> | ||
==Pathophysiology== | ==Pathophysiology== | ||
Revision as of 19:52, 9 October 2015
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Hypopharyngeal cancer Microchapters |
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Hypopharyngeal cancer pathophysiology On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Faizan Sheraz, M.D. [2]
Overview
Genes involved in the pathogenesis of hypopharyngeal cancer include p16, NOTCH1, cyclin D1, and TP53. Hypopharyngeal cancer is associated with sideropaenic dysphagia and Paterson Brown Kelly syndrome.On gross pathology, flattened plaques, mucosal ulceration, and raised margins of the lesion are characteristic findings of hypopharyngeal cancer. On microscopic histopathological analysis, spindle cells, basaloid cells, and nuclear atypia are characteristic findings of hypopharyngeal cancer.[1]
Pathophysiology
Genetics
Genes involved in the pathogenesis of hypopharyngeal cancer include:
Associated Diseases
Hypopharyngeal carcinoma is associated with:[1]
- Sideropaenic dysphagia
- Paterson Brown Kelly syndrome
Gross Pathology
Gross pathology of hypopharyngeal cancer includes:[1]
- Flattened plaques
- Raised margins of the lesion
- Mucosal ulceration
- Tumor spread to piriform sinus
Microscopic Pathology
Microscopic features of hypopharyngeal carcinoma include:[1]
- Spindle cells
- Basaloid cells
- Nuclear atypia
- Abundant chromatin