Neuroblastoma natural history: Difference between revisions
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==Overview== | ==Overview== | ||
If left untreated, patients with neuroblastoma may progress to develop fatigue, loss of appetite, joint pain, and fever. Complications of neuroblastoma may include persistent refractory diarrhea, Horner's syndrome, and transverse myelopathy. Depending on the extent of the tumor at the time of diagnosis, the prognosis may vary. However, the prognosis of neuroblastoma is generally regarded as poor.<ref name="radio">Neuroblastoma. Radiopaedia(2015) http://radiopaedia.org/articles/neuroblastoma Accessed on October, 5 2015</ref><ref name="wiki">Neuroblastoma. Wikipedia(2015) https://en.wikipedia.org/wiki/Neuroblastoma Accessed on October, 5 2015</ref><ref name="gov"> Neuroblastoma Treatment for health professionals. National Cancer Institute (2015) http://www.cancer.gov/types/neuroblastoma/hp/neuroblastoma-treatment-pdq#link/_534_toc Accessed on October, 7 2015</ref><ref name="patho"> Neuroblastoma. Libre Pathology(2015) http://librepathology.org/wiki/index.php/Adrenal_gland#Neuroblastoma Accessed on October, 5 2015</ref> | If left untreated, patients with neuroblastoma may progress to develop fatigue, loss of appetite, joint pain, and fever. Complications of neuroblastoma may include persistent refractory diarrhea, Horner's syndrome, and transverse myelopathy. Depending on the extent of the tumor at the time of diagnosis, the prognosis may vary. However, the prognosis of neuroblastoma is generally regarded as poor.<ref name="radio">Neuroblastoma. Radiopaedia (2015) http://radiopaedia.org/articles/neuroblastoma Accessed on October, 5 2015</ref><ref name="wiki">Neuroblastoma. Wikipedia (2015) https://en.wikipedia.org/wiki/Neuroblastoma Accessed on October, 5 2015</ref><ref name="gov"> Neuroblastoma Treatment for health professionals. National Cancer Institute (2015) http://www.cancer.gov/types/neuroblastoma/hp/neuroblastoma-treatment-pdq#link/_534_toc Accessed on October, 7 2015</ref><ref name="patho"> Neuroblastoma. Libre Pathology (2015) http://librepathology.org/wiki/index.php/Adrenal_gland#Neuroblastoma Accessed on October, 5 2015</ref> | ||
==Natural History== | ==Natural History== | ||
Revision as of 21:15, 11 October 2015
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Neuroblastoma Microchapters |
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Neuroblastoma natural history On the Web |
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American Roentgen Ray Society Images of Neuroblastoma natural history |
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Risk calculators and risk factors for Neuroblastoma natural history |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]
Overview
If left untreated, patients with neuroblastoma may progress to develop fatigue, loss of appetite, joint pain, and fever. Complications of neuroblastoma may include persistent refractory diarrhea, Horner's syndrome, and transverse myelopathy. Depending on the extent of the tumor at the time of diagnosis, the prognosis may vary. However, the prognosis of neuroblastoma is generally regarded as poor.[1][2][3][4]
Natural History
- Neuroblastoma patients may initially present with vague symptoms making the diagnosis of such patients difficult.
- If left untreated, patients with neuroblastoma may progress to develop fatigue, loss of appetite, joint pain, and fever.
- Gradual development of site specific symptoms may occur as the tumor size gradually increases.[2]
Complications
- Complications of neuroblastoma may include:[2]
- Persistent refractory diarrhea (due to vasoactive intestinal peptide secretion)
- Horner's syndrome (due to cervical sympathetic chain compression)
- Opsoclonus myoclonus syndrome and ataxia (due to a paraneoplastic syndrome)
- Hypertension (due to either catecholamine secretion or renal artery compression)
- Transverse myelopathy (due to tumor spinal cord compression)
- Anemia and suppressed immunity (due to bone marrow metastasis)
Prognosis
- Depending on the extent of the tumor at the time of diagnosis, the prognosis may vary. However, the prognosis of neuroblastoma is generally regarded as poor.
- INSS stage 1, stage 2, and stage 4S neuroblastomas are associated with a 3 year survival rate of 75-90%.
- INSS stage 3 neuroblastoma is associated with a 3 year survival rate of 80-90% among patients younger than 1 year of age.
- INSS stage 3 neuroblastoma is associated with a 3 year survival rate of 50% among patients older than 1 year of age.
- INSS stage 4 neuroblastoma is associated with a 3 year survival rate of 60-75% among patients younger than 1 year of age.
- INSS stage 4 neuroblastoma is associated with a 3 year survival rate of 15% among patients older than 1 year of age.
- The table below lists the prognostic factors for neuroblastoma patients:[1][2][3][4]
| Prognostic Factor | Description |
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| Patient's Age |
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| Tumor Stage |
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| Tumor Grade |
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| Schwannnian Stroma |
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| Mitotic-karyorrhectic Index |
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| Genetics Mutations |
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| Response to Treatment |
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References
- ↑ 1.0 1.1 Neuroblastoma. Radiopaedia (2015) http://radiopaedia.org/articles/neuroblastoma Accessed on October, 5 2015
- ↑ 2.0 2.1 2.2 2.3 Neuroblastoma. Wikipedia (2015) https://en.wikipedia.org/wiki/Neuroblastoma Accessed on October, 5 2015
- ↑ 3.0 3.1 Neuroblastoma Treatment for health professionals. National Cancer Institute (2015) http://www.cancer.gov/types/neuroblastoma/hp/neuroblastoma-treatment-pdq#link/_534_toc Accessed on October, 7 2015
- ↑ 4.0 4.1 Neuroblastoma. Libre Pathology (2015) http://librepathology.org/wiki/index.php/Adrenal_gland#Neuroblastoma Accessed on October, 5 2015