Testicular cancer pathophysiology: Difference between revisions
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==Overview== | ==Overview== | ||
On microscopic histopathological analysis of testicular cancer, fried-egg appearance is the characteristic finding of [[seminoma]]; marked | On microscopic histopathological analysis of testicular cancer, fried-egg appearance is the characteristic finding of [[seminoma]]; marked nuclear atypia is the characteristic finding of [[embryonal carcinoma]]; blander cytomorphology, hyaline-type globules, and Schiller-Duval bodies are characteristic findings of [[yolk sac tumor ]]; both syncytiotrophoblasts and cytotrophoblast cells is the characteristic finding of [[choriocarcinoma]]. | ||
==Pathophysiology== | ==Pathophysiology== | ||
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==Microscopic Pathology== | ==Microscopic Pathology== | ||
'''Germ cell Tumors'''<ref name="pmid6093440">{{cite journal| author=Krag Jacobsen G, Barlebo H, Olsen J, Schultz HP, Starklint H, Søgaard H et al.| title=Testicular germ cell tumours in Denmark 1976-1980. Pathology of 1058 consecutive cases. | journal=Acta Radiol Oncol | year= 1984 | volume= 23 | issue= 4 | pages= 239-47 | pmid=6093440 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6093440 }} </ref> | '''Germ cell Tumors'''<ref name="pmid6093440">{{cite journal| author=Krag Jacobsen G, Barlebo H, Olsen J, Schultz HP, Starklint H, Søgaard H et al.| title=Testicular germ cell tumours in Denmark 1976-1980. Pathology of 1058 consecutive cases. | journal=Acta Radiol Oncol | year= 1984 | volume= 23 | issue= 4 | pages= 239-47 | pmid=6093440 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6093440 }} </ref> | ||
* Seminoma | * [[Seminoma]] | ||
:* Clonal proliferation of neoplastic [[germ cells]] | :* Clonal proliferation of neoplastic [[germ cells]] | ||
:* Fried-egg appearance | :* Fried-egg appearance | ||
* Non-seminomas | * Non-seminomas | ||
:* Embryonal carcinoma<ref name="pmid6155988">{{cite journal| author=Talerman A, Haije WG, Baggerman L| title=Serum alphafetoprotein (AFP) in patients with germ cell tumors of the gonads and extragonadal sites: correlation between endodermal sinus (yolk sac) tumor and raised serum AFP. | journal=Cancer | year= 1980 | volume= 46 | issue= 2 | pages= 380-5 | pmid=6155988 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6155988 }} </ref> | :* [[Embryonal carcinoma]]<ref name="pmid6155988">{{cite journal| author=Talerman A, Haije WG, Baggerman L| title=Serum alphafetoprotein (AFP) in patients with germ cell tumors of the gonads and extragonadal sites: correlation between endodermal sinus (yolk sac) tumor and raised serum AFP. | journal=Cancer | year= 1980 | volume= 46 | issue= 2 | pages= 380-5 | pmid=6155988 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6155988 }} </ref> | ||
::* Marked nuclear atypia | ::* Marked nuclear atypia | ||
:* Yolk sac tumor<ref name="pmid6093440">{{cite journal| author=Krag Jacobsen G, Barlebo H, Olsen J, Schultz HP, Starklint H, Søgaard H et al.| title=Testicular germ cell tumours in Denmark 1976-1980. Pathology of 1058 consecutive cases. | journal=Acta Radiol Oncol | year= 1984 | volume= 23 | issue= 4 | pages= 239-47 | pmid=6093440 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6093440 }} </ref> | :* [[Yolk sac tumor]]<ref name="pmid6093440">{{cite journal| author=Krag Jacobsen G, Barlebo H, Olsen J, Schultz HP, Starklint H, Søgaard H et al.| title=Testicular germ cell tumours in Denmark 1976-1980. Pathology of 1058 consecutive cases. | journal=Acta Radiol Oncol | year= 1984 | volume= 23 | issue= 4 | pages= 239-47 | pmid=6093440 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6093440 }} </ref> | ||
::* Blander cytomorphology | ::* Blander cytomorphology | ||
::* Hyaline-type globules | ::* Hyaline-type globules | ||
::* Schiller-Duval bodies | ::* Schiller-Duval bodies | ||
:* Choriocarcinoma | :* [[Choriocarcinoma]] | ||
::* Both syncytiotrophoblasts and cytotrophoblast cells | ::* Both syncytiotrophoblasts and cytotrophoblast cells | ||
Revision as of 14:53, 19 October 2015
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Testicular cancer Microchapters |
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Testicular cancer pathophysiology On the Web |
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Risk calculators and risk factors for Testicular cancer pathophysiology |
Overview
On microscopic histopathological analysis of testicular cancer, fried-egg appearance is the characteristic finding of seminoma; marked nuclear atypia is the characteristic finding of embryonal carcinoma; blander cytomorphology, hyaline-type globules, and Schiller-Duval bodies are characteristic findings of yolk sac tumor ; both syncytiotrophoblasts and cytotrophoblast cells is the characteristic finding of choriocarcinoma.
Pathophysiology
- More than 90% of all testicular cancers are germ cell tumors. This type of cancer starts in germ cells, which are the cells that make sperm.[1]
- About 50% of all germ cell tumours are seminomas, or seminomatous germ cell tumours. They grow slower than non-seminomas.
Microscopic Pathology
Germ cell Tumors[2]
- Clonal proliferation of neoplastic germ cells
- Fried-egg appearance
- Non-seminomas
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- Marked nuclear atypia
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- Blander cytomorphology
- Hyaline-type globules
- Schiller-Duval bodies
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- Both syncytiotrophoblasts and cytotrophoblast cells
References
- ↑ Testicular cancer. Canadian Cancer Society 2015. http://www.cancer.ca/en/cancer-information/cancer-type/testicular/testicular-cancer/cancerous-tumours/?region=ab Accessed on October, 13 2015
- ↑ 2.0 2.1 Krag Jacobsen G, Barlebo H, Olsen J, Schultz HP, Starklint H, Søgaard H; et al. (1984). "Testicular germ cell tumours in Denmark 1976-1980. Pathology of 1058 consecutive cases". Acta Radiol Oncol. 23 (4): 239–47. PMID 6093440.
- ↑ Talerman A, Haije WG, Baggerman L (1980). "Serum alphafetoprotein (AFP) in patients with germ cell tumors of the gonads and extragonadal sites: correlation between endodermal sinus (yolk sac) tumor and raised serum AFP". Cancer. 46 (2): 380–5. PMID 6155988.