Hairy cell leukemia classification: Difference between revisions
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==Overview== | ==Overview== | ||
* Hairy cell leukemia may be classified into two subtypes: Hairy cell leukemia (classic) and hairy cell leukemia variant.<ref name="wiki">Hairy cell leukemia. Wikipedia (2015) https://en.wikipedia.org/wiki/Hairy_cell_leukemia#Classification Accessed on October, 17 2015</ref> | |||
==Classification== | ==Classification== | ||
* Hairy cell leukemia may be classified into two subtypes: Hairy cell leukemia (classic) and hairy cell leukemia variant.<ref name="wiki">Hairy cell leukemia. Wikipedia (2015) https://en.wikipedia.org/wiki/Hairy_cell_leukemia#Classification Accessed on October, 17 2015</ref> | |||
* Hairy cell leukemia variant is still considered a provisional entity at this time, as the WHO is unable to recognize it as distinct diseases due to insufficient evidence.<ref name="pmid21300984">{{cite journal| author=Campo E, Swerdlow SH, Harris NL, Pileri S, Stein H, Jaffe ES| title=The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications. | journal=Blood | year= 2011 | volume= 117 | issue= 19 | pages= 5019-32 | pmid=21300984 | doi=10.1182/blood-2011-01-293050 | pmc=PMC3109529 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21300984 }} </ref> | |||
* The algorithm below illustrates characteristic findings associated with each subtypes:<ref name="pmid16990106">{{cite journal| author=Matutes E| title=Immunophenotyping and differential diagnosis of hairy cell leukemia. | journal=Hematol Oncol Clin North Am | year= 2006 | volume= 20 | issue= 5 | pages= 1051-63 | pmid=16990106 | doi=10.1016/j.hoc.2006.06.012 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16990106 }} </ref> | |||
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{{familytree/start |summary=Molecular classification criteria}} | |||
{{familytree | | | | | | | | Y01 | | | | | | | | | Y01=<div style="width: 20em; padding:0.5em;">'''Hairy cell leukemia classification'''</div>}} | |||
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{{familytree | | | | A02 | | | | | | A03 | | | | | | | A02=<div style="width: 25em; padding:0.5em;">'''Hairy cell leukemia'''</div>|A03=<div style="width: 25em; padding:0.5em;">'''Hairy cell leukemia variant'''</div>}} | |||
{{familytree|boxstyle= border-top: 0px; | | | | A02 | | | | | | A03 | | | | | | | | | A02=<div style="width: 25em; padding:0.5em;text-align:left"> | |||
* '''Occurs in approximately 95% of the cases'''<br> | |||
* '''The male to female ratio is approximately 4 to 1'''<br> | |||
* '''The median age at diagnosis is 55 years'''<br> | |||
* '''Less than 10% lymphocytosis on peripheral blood smear'''<br> | |||
* '''Decreased level of monocyte on peripheral blood smear'''<br> | |||
* '''Decreased hemoglobin level in approximately 85% of the patients'''<br> | |||
* '''Thrombocytopenia is present in approximately 80% of the patients'''<br> | |||
* '''CD103+, CD11c+, and CD25+ on immunophenotype'''<br> | |||
* '''DBA.44+, Cyclin D1+, and Annexin A1+ on immunohistochemistry'''<br> | |||
* '''Presence of BRAF V600E mutation on cytogenetic tests''' | |||
</div>|A03=<div style="width: 25em; padding:0.5em;text-align:left"> | |||
* '''Occurs in approximately 5% of the cases'''<br> | |||
* '''The male to female ratio is approximately 2 to 1'''<br> | |||
* '''The median age at diagnosis is greater than 70 years'''<br> | |||
* '''greater than 90% lymphocytosis on peripheral blood smear'''<br> | |||
* '''Normal level of monocyte on peripheral blood smear'''<br> | |||
* '''Normal hemoglobin level in most of the patients'''<br> | |||
* '''Normal platelets count in most of the patients'''<br> | |||
* '''CD103+, CD11c+, and CD25- on immunophenotype'''<br> | |||
* '''DBA.44+, Cyclin D1+, and Annexin A1- on immunohistochemistry'''<br> | |||
* '''Presence of BRAF wild type mutation on cytogenetic tests'''</div>}} | |||
{{familytree/end}} | |||
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==References== | ==References== | ||
Revision as of 20:20, 19 October 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
- Hairy cell leukemia may be classified into two subtypes: Hairy cell leukemia (classic) and hairy cell leukemia variant.[1]
Classification
- Hairy cell leukemia may be classified into two subtypes: Hairy cell leukemia (classic) and hairy cell leukemia variant.[1]
- Hairy cell leukemia variant is still considered a provisional entity at this time, as the WHO is unable to recognize it as distinct diseases due to insufficient evidence.[2]
- The algorithm below illustrates characteristic findings associated with each subtypes:[3]
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Hairy cell leukemia | Hairy cell leukemia variant | ||||||||||||||||||||||||||||||||||||||||||
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References
- ↑ 1.0 1.1 Hairy cell leukemia. Wikipedia (2015) https://en.wikipedia.org/wiki/Hairy_cell_leukemia#Classification Accessed on October, 17 2015
- ↑ Campo E, Swerdlow SH, Harris NL, Pileri S, Stein H, Jaffe ES (2011). "The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications". Blood. 117 (19): 5019–32. doi:10.1182/blood-2011-01-293050. PMC 3109529. PMID 21300984.
- ↑ Matutes E (2006). "Immunophenotyping and differential diagnosis of hairy cell leukemia". Hematol Oncol Clin North Am. 20 (5): 1051–63. doi:10.1016/j.hoc.2006.06.012. PMID 16990106.