Hairy cell leukemia differential diagnosis: Difference between revisions

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Revision as of 11:15, 21 October 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]

Overview

Chronic lymphocytic leukemia must be differentiated from other diseases that cause weight loss, night sweats, hepatosplenomegaly, and palpable lymph nodes, such as hairy cell leukaemia, prolymphocytic leukaemia, follicular lymphoma, and mantle cell lymphoma.^[1]

Differenting Chronic lymphocytic leukemia from other Diseases

Chronic lymphocytic leukemia must be differentiated from other diseases that cause weight loss, night sweats, hepatosplenomegaly, and palpable lymph nodes, such as hairy cell leukaemia, prolymphocytic leukaemia, follicular lymphoma, and mantle cell lymphoma.
Based on the expression of cell surface markers, the table below differentiates chronic lymphocytic leukemia from other diseases that cause similar clinical presentations:^[1]


Differential Diagnosis	Surface Immunoglobulin	CD5	CD22/FMC7	CD23	CD79b	CD103

Chronic lymphocytic leukaemia	Weakly positive	Positive	Negative	Positive	Negative	Positive/Negative
Prolymphocytic leukaemia	Strongly positive	Negative	Positive	Negative	Positive	Negative
Hairy cell leukaemia	Strongly positive	Negative	Positive	Negative	Positive/Negative	Positive
Mantle cell lymphoma	Positive	Positive	Strongly positive	Negative	Strongly positive	Negative
Follicular lymphoma	Strongly positive	Negative	Positive	Negative	Strongly positive	Negative

Chronic lymphocytic leukemia must also be differentiated from other causes of fever, hepatosplenomegaly, and lymph node swelling such as:^[2]

References

↑ ^1.0 ^1.1 Hoffbrand V, Moss P. Essential Haematology. John Wiley & Sons; 2011
↑ Chronic Lymphocytic Leukimea. Wikipedia (2015) https://en.wikipedia.org/wiki/B-cell_chronic_lymphocytic_leukemia Accessed on October ,12 2015

Template:WikiDoc Sources

[H-1] 1.0 ^1.1 Hoffbrand V, Moss P. Essential Haematology. John Wiley & Sons; 2011

[wiki-2] Chronic Lymphocytic Leukimea. Wikipedia (2015) https://en.wikipedia.org/wiki/B-cell_chronic_lymphocytic_leukemia Accessed on October ,12 2015

[1]

[2]

@@ Line 1: / Line 1: @@
 __NOTOC__
 {{Hairy cell leukemia}}
+{{CMG}} {{AE}}{{HL}}
+==Overview==
+* Chronic lymphocytic leukemia must be differentiated from other diseases that cause [[weight loss]],  [[night sweats]], [[hepatosplenomegaly]], and palpable [[lymph node]]s, such as [[hairy cell leukaemia]], prolymphocytic leukaemia, [[follicular lymphoma]], and [[mantle cell lymphoma]].<ref name="H">Hoffbrand V, Moss P. Essential Haematology. John Wiley & Sons; 2011</ref>
-Please help WikiDoc by adding content here.  It's easy!  Click  [[Help:How_to_Edit_a_Page|here]]  to learn about editing.
+==Differenting Chronic lymphocytic leukemia from other Diseases==
+* Chronic lymphocytic leukemia must be differentiated from other diseases that cause [[weight loss]],  [[night sweats]], [[hepatosplenomegaly]], and palpable [[lymph node]]s, such as [[hairy cell leukaemia]], prolymphocytic leukaemia, [[follicular lymphoma]], and [[mantle cell lymphoma]].
+* Based on the expression of cell surface markers, the table below differentiates chronic lymphocytic leukemia from other diseases that cause similar clinical presentations:<ref name="H">Hoffbrand V, Moss P. Essential Haematology. John Wiley & Sons; 2011</ref>
+<br>
+{| style="border: 0px; font-size: 90%; margin: 3px; width: 1000px"
+|valign=top|
+|+
+! style="background: #4479BA; width: 600px;" | {{fontcolor|#FFF|'''Differential Diagnosis'''}}
+! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|'''Surface Immunoglobulin'''}}
+! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|'''CD5'''}}
+! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|'''CD22/FMC7'''}}
+! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|'''CD23'''}}
+! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|'''CD79b'''}}
+! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|'''CD103'''}}
+|-
+| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
+'''Chronic lymphocytic leukaemia'''
+| style="padding: 5px 5px; background: #F5F5F5;" align=center |
+'''Weakly positive'''
+| style="padding: 5px 5px; background: #F5F5F5;" align=center |
+'''Positive'''
+| style="padding: 5px 5px; background: #F5F5F5;" align=center |
+'''Negative'''
+| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+'''Positive'''
+| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+'''Negative'''
+| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+'''Positive/Negative'''
+|-
+| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
+'''Prolymphocytic leukaemia'''
+| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+'''Strongly positive'''
+| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+'''Negative'''
+| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+'''Positive'''
+| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+'''Negative'''
+| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+'''Positive'''
+| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+'''Negative'''
+|-
+| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
+'''Hairy cell leukaemia'''
+| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+'''Strongly positive'''
+| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+'''Negative'''
+| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+'''Positive'''
+| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+'''Negative'''
+| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+'''Positive/Negative'''
+| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+'''Positive'''
+|-
+| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
+'''Mantle cell lymphoma'''
+| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+'''Positive'''
+| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+'''Positive'''
+| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+'''Strongly positive'''
+| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+'''Negative'''
+| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+'''Strongly positive'''
+| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+'''Negative'''
+|-
+| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
+'''Follicular lymphoma'''
+| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+'''Strongly positive'''
+| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+'''Negative'''
+| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+'''Positive'''
+| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+'''Negative'''
+| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+'''Strongly positive'''
+| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+'''Negative'''
+|}
+<br>
+* Chronic lymphocytic leukemia must also be differentiated from other causes of fever, hepatosplenomegaly, and lymph node swelling such as:<ref name="wiki">Chronic Lymphocytic Leukimea. Wikipedia (2015) https://en.wikipedia.org/wiki/B-cell_chronic_lymphocytic_leukemia Accessed on October ,12 2015</ref>
+:* [[Splenic marginal zone lymphoma]]
+:* Nodal marginal zone [[lymphoma]]
+:* [[Lymphoplasmacytic lymphoma]]
+:* [[Sézary syndrome]]
+:* Smoldering [[adult T cell leukemia]]
 ==References==

Hairy cell leukemia differential diagnosis: Difference between revisions

Revision as of 11:15, 21 October 2015

Overview

Differenting Chronic lymphocytic leukemia from other Diseases

References

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