Cholangiocarcinoma classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Suveenkrishna Pothuru, M.B,B.S. [2]

Classification

Extrahepatic Bile Duct Cancer Adenocarcinomas are the most common type of extrahepatic bile duct tumors. The histologic types include the following:[1]

Carcinoma in situ. Adenocarcinoma, not otherwise specified (NOS). Adenocarcinoma, intestinal type. Mucinous adenocarcinoma. Clear cell adenocarcinoma. Signet-ring cell carcinoma. Adenosquamous carcinoma. Squamous cell carcinoma. Small cell (oat cell) carcinoma. Undifferentiated carcinoma.

Spindle and giant cell types. Small cell types.

Papillomatosis. Papillary carcinoma, noninvasive. Papillary carcinoma, invasive. Carcinoma, NOS.

Perihilar Bile Duct Cancer Adenocarcinomas are the most common type of perihilar bile duct tumors. The histologic types include the following:

Carcinoma in situ. Adenocarcinoma, not otherwise specified (NOS). Adenocarcinoma, intestinal type. Mucinous adenocarcinoma. Clear cell adenocarcinoma. Signet-ring cell carcinoma. Adenosquamous carcinoma. Squamous cell carcinoma. Small cell (oat cell) carcinoma. Undifferentiated carcinoma

Spindle and giant cell types. Small cell types.

Papillomatosis. Papillary carcinoma, noninvasive. Papillary carcinoma, invasive. Carcinoma, NOS

Intrahepatic Bile Duct Cancer The most common histologic types of intrahepatic bile duct tumors include the following:

Intrahepatic cholangiocarcinoma.

Mass-forming tumor growth pattern. Periductal-infiltrating tumor growth pattern. Mixed mass-forming and periductal-infiltrating growth pattern.

Mixed hepatocellular.