Cholangiocarcinoma classification

Cholangiocarcinoma Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Cholangiocarcinoma from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Diagnostic Study of Choice
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
X-ray
CT
MRI
Echocardiography or Ultrasound
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Cholangiocarcinoma classification On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Cholangiocarcinoma classification All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Cholangiocarcinoma classification
CDC on Cholangiocarcinoma classification
Cholangiocarcinoma classification in the news
Blogs on Cholangiocarcinoma classification
Directions to Hospitals Treating Cholangiocarcinoma
Risk calculators and risk factors for Cholangiocarcinoma classification

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Suveenkrishna Pothuru, M.B,B.S. [2]

Classification

Cholangiocarcinoma may be classified according to location of the tumor into 3 subtypes:

• Extrahepatic Bile Duct Cancer
• Perihilar Bile Duct Cancer
• Intrahepatic Bile Duct Cancer

Cellular Classification of Cholangiocarcinoma

Extrahepatic Bile Duct Cancer Adenocarcinomas are the most common type of extrahepatic bile duct tumors. The histologic subtypes include:

• Carcinoma in situ
• Adenocarcinoma, not otherwise specified (NOS)
• Adenocarcinoma, intestinal type
• Mucinous adenocarcinoma
• Clear cell adenocarcinoma
• Signet-ring cell carcinoma
• Adenosquamous carcinoma
• Squamous cell carcinoma
• Small cell (oat cell) carcinoma
• Undifferentiated carcinoma

• Spindle and giant cell types
• Small cell types

• Papillomatosis
• Papillary carcinoma, noninvasive
• Papillary carcinoma, invasive
• Carcinoma, NOS

Perihilar Bile Duct Cancer Adenocarcinomas are the most common type of perihilar bile duct tumors. The histologic types include the following:

Carcinoma in situ. Adenocarcinoma, not otherwise specified (NOS). Adenocarcinoma, intestinal type. Mucinous adenocarcinoma. Clear cell adenocarcinoma. Signet-ring cell carcinoma. Adenosquamous carcinoma. Squamous cell carcinoma. Small cell (oat cell) carcinoma. Undifferentiated carcinoma

Spindle and giant cell types. Small cell types.

Papillomatosis. Papillary carcinoma, noninvasive. Papillary carcinoma, invasive. Carcinoma, NOS

Intrahepatic Bile Duct Cancer The most common histologic types of intrahepatic bile duct tumors include the following:

Intrahepatic cholangiocarcinoma.

Mass-forming tumor growth pattern. Periductal-infiltrating tumor growth pattern. Mixed mass-forming and periductal-infiltrating growth pattern.

Mixed hepatocellular.