Hepatoblastoma risk factors

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Nawal Muazam M.D.[2]

Risk Factors

Risk factors for hepatoblastoma including the following:

• Being male.
• Having familial adenomatous polyposis (FAP).
• Having Beckwith-Wiedemann syndrome.
• Having had a very low weight at birth.

Associated Disorder	Clinical findings
Aicardi syndrome	Agenesis of the corpus callosum, chorioretinal lacunae, and infantile spasms, with a characteristic facies.
Beckwith-Wiedemann syndrome	Hemihypertrophy, hemihyperplasia.
Familial adenomatous polyposis
Glycogen storage diseases I–IV	Symptoms vary by individual disorder.
Low-birth-weight infants	Preterm and small-for-gestation-age neonates.
Simpson-Golabi-Behmel syndrome	Macroglossia, macrosomia, renal and skeletal abnormalities, and increased risk of Wilms tumor.
Trisomy 18, other trisomies	Trisomy 18: Microcephaly and micrognathia, clenched fists with overlapping fingers, and failure to thrive. Most patients (>90%) die in the first month of life.

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