Hairy cell leukemia laboratory tests: Difference between revisions
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===Blood Smear=== | ===Blood Smear=== | ||
* Hairy cells with thread-like cytoplasmic extensions<ref>{{cite journal |vauthors=Somasundaram V, Purohit A, Aggarwal M, Manivannan P, Mishra P, Seth T, Tyagi S, Mahapatra M, Pati HP, Saxena R |title=Hairy cell leukemia: A decade long experience of North Indian Hematology Center |journal=Indian J Med Paediatr Oncol |volume=35 |issue=4 |pages=271–5 |year=2014 |pmid=25538404 |pmc=4264273 |doi=10.4103/0971-5851.144988 |url=}}</ref> | * Hairy cells with thread-like [[cytoplasmic]] extensions<ref>{{cite journal |vauthors=Somasundaram V, Purohit A, Aggarwal M, Manivannan P, Mishra P, Seth T, Tyagi S, Mahapatra M, Pati HP, Saxena R |title=Hairy cell leukemia: A decade long experience of North Indian Hematology Center |journal=Indian J Med Paediatr Oncol |volume=35 |issue=4 |pages=271–5 |year=2014 |pmid=25538404 |pmc=4264273 |doi=10.4103/0971-5851.144988 |url=}}</ref> | ||
* Positive TRAP stain | * Positive TRAP stain | ||
===Immunohistochemistry=== | ===Immunohistochemistry=== | ||
* Hairy cell leukemia cells typically express:<ref>{{cite journal |vauthors=Somasundaram V, Purohit A, Aggarwal M, Manivannan P, Mishra P, Seth T, Tyagi S, Mahapatra M, Pati HP, Saxena R |title=Hairy cell leukemia: A decade long experience of North Indian Hematology Center |journal=Indian J Med Paediatr Oncol |volume=35 |issue=4 |pages=271–5 |year=2014 |pmid=25538404 |pmc=4264273 |doi=10.4103/0971-5851.144988 |url=}}</ref> | * Hairy cell leukemia cells typically express:<ref>{{cite journal |vauthors=Somasundaram V, Purohit A, Aggarwal M, Manivannan P, Mishra P, Seth T, Tyagi S, Mahapatra M, Pati HP, Saxena R |title=Hairy cell leukemia: A decade long experience of North Indian Hematology Center |journal=Indian J Med Paediatr Oncol |volume=35 |issue=4 |pages=271–5 |year=2014 |pmid=25538404 |pmc=4264273 |doi=10.4103/0971-5851.144988 |url=}}</ref> | ||
:* Annexin A1 +ve | :* [[Annexin A1]] +ve | ||
:* CD20 +ve | :* [[CD20]] +ve | ||
:* CD25 +ve | :* [[CD25]] +ve | ||
:* CD103 +ve | :* [[CD103]] +ve | ||
===Flow Cytometry=== | ===Flow Cytometry=== | ||
* Hairy cell leukemia cells typically express:<ref>{{cite journal |vauthors=Somasundaram V, Purohit A, Aggarwal M, Manivannan P, Mishra P, Seth T, Tyagi S, Mahapatra M, Pati HP, Saxena R |title=Hairy cell leukemia: A decade long experience of North Indian Hematology Center |journal=Indian J Med Paediatr Oncol |volume=35 |issue=4 |pages=271–5 |year=2014 |pmid=25538404 |pmc=4264273 |doi=10.4103/0971-5851.144988 |url=}}</ref> | * Hairy cell leukemia cells typically express:<ref>{{cite journal |vauthors=Somasundaram V, Purohit A, Aggarwal M, Manivannan P, Mishra P, Seth T, Tyagi S, Mahapatra M, Pati HP, Saxena R |title=Hairy cell leukemia: A decade long experience of North Indian Hematology Center |journal=Indian J Med Paediatr Oncol |volume=35 |issue=4 |pages=271–5 |year=2014 |pmid=25538404 |pmc=4264273 |doi=10.4103/0971-5851.144988 |url=}}</ref> | ||
:* CD19 +ve | :* [[CD19]] +ve | ||
:* CD11c +ve | :* [[CD11c]] +ve | ||
:* FMC7 +ve | :* [[FMC7]] +ve | ||
==References== | ==References== | ||
Revision as of 19:36, 29 October 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Laboratory Findings
Complete Blood Count
- Decreased hemoglobin concentration[1]
- Decreased platelets count
- Decreased WBC count
Blood Smear
- Hairy cells with thread-like cytoplasmic extensions[2]
- Positive TRAP stain
Immunohistochemistry
- Hairy cell leukemia cells typically express:[3]
- Annexin A1 +ve
- CD20 +ve
- CD25 +ve
- CD103 +ve
Flow Cytometry
- Hairy cell leukemia cells typically express:[4]
References
- ↑ Somasundaram V, Purohit A, Aggarwal M, Manivannan P, Mishra P, Seth T, Tyagi S, Mahapatra M, Pati HP, Saxena R (2014). "Hairy cell leukemia: A decade long experience of North Indian Hematology Center". Indian J Med Paediatr Oncol. 35 (4): 271–5. doi:10.4103/0971-5851.144988. PMC 4264273. PMID 25538404.
- ↑ Somasundaram V, Purohit A, Aggarwal M, Manivannan P, Mishra P, Seth T, Tyagi S, Mahapatra M, Pati HP, Saxena R (2014). "Hairy cell leukemia: A decade long experience of North Indian Hematology Center". Indian J Med Paediatr Oncol. 35 (4): 271–5. doi:10.4103/0971-5851.144988. PMC 4264273. PMID 25538404.
- ↑ Somasundaram V, Purohit A, Aggarwal M, Manivannan P, Mishra P, Seth T, Tyagi S, Mahapatra M, Pati HP, Saxena R (2014). "Hairy cell leukemia: A decade long experience of North Indian Hematology Center". Indian J Med Paediatr Oncol. 35 (4): 271–5. doi:10.4103/0971-5851.144988. PMC 4264273. PMID 25538404.
- ↑ Somasundaram V, Purohit A, Aggarwal M, Manivannan P, Mishra P, Seth T, Tyagi S, Mahapatra M, Pati HP, Saxena R (2014). "Hairy cell leukemia: A decade long experience of North Indian Hematology Center". Indian J Med Paediatr Oncol. 35 (4): 271–5. doi:10.4103/0971-5851.144988. PMC 4264273. PMID 25538404.