Subependymal giant cell astrocytoma pathophysiology: Difference between revisions
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{{Subependymal giant cell astrocytoma}} | {{Subependymal giant cell astrocytoma}} | ||
{{CMG}}{{AE}}{{SR}} | |||
==Overview== | |||
==Pathophysiology== | |||
===Genetic=== | |||
*Development of subependymal giant cell astrocytoma is the result of multiple genetic mutations. | |||
*Genes involved in the pathogenesis of subependymal giant cell astrocytoma include: | |||
===Associated Conditions=== | |||
Subependymal giant cell astrocytoma may be associated with [[tuberous sclerosis]].<ref name=AssociationPA1>Associations of pilocytic astrocytoma. Dr Bruno Di Muzio and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/pilocytic-astrocytoma. Accessed on October 26, 2015</ref> | |||
===Gross Pathology=== | |||
*On gross pathology, subependymal giant cell astrocytoma is characterized by: | |||
*Common intracranial sites associated with subependymal giant cell astrocytoma include: | |||
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! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|'''Anatomical Location'''}} | |||
! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|'''Summary'''}} | |||
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*[[Cerebellum]] | |||
*[[Third ventricle]] | |||
*[[Optic nerve]] | |||
*[[Optic chiasm]] | |||
*[[Hypothalamus]] | |||
*[[Thalamus]] | |||
*[[Basal ganglia]] | |||
*[[Brain stem]] | |||
*[[Fourth ventricle]] | |||
*[[Spinal cord]] | |||
*[[Cerebral hemisphere]]s | |||
*[[Supratentorial|Supratentorial NOS]] | |||
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[[File:Location of pilocytic astrocytoma.PNG|thumb|none|700px|<sub>Neuroanatomical distribution of aneuploid pilocytic astrocytoma tumors favors non-cerebellar areas.<ref name=locPA1>{{cite journal|title=Non-random aneuploidy specifies subgroups of pilocytic astrocytoma and correlates with older age|journal=Oncotarget|year=2015|issn=1949-2553|doi=10.18632/oncotarget.5571}}</ref></sub>]] | |||
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===Microscopic pathology=== | |||
On microscopic histopathological analysis, subependymal giant cell astrocytoma is characterized by: | |||
According to the ''WHO classification of tumors of the central nervous system'', subependymal giant cell astrocytoma is classified into a WHO grade I tumor. | |||
===Immunohistochemistry=== | |||
Subependymal giant cell astrocytoma is demonstrated by positivity to [[tumor marker]]s such as: | |||
==Reference== | ==Reference== | ||
{{reflist|2}} | {{reflist|2}} | ||
Revision as of 21:07, 2 November 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Pathophysiology
Genetic
- Development of subependymal giant cell astrocytoma is the result of multiple genetic mutations.
- Genes involved in the pathogenesis of subependymal giant cell astrocytoma include:
Associated Conditions
Subependymal giant cell astrocytoma may be associated with tuberous sclerosis.[1]
Gross Pathology
- On gross pathology, subependymal giant cell astrocytoma is characterized by:
- Common intracranial sites associated with subependymal giant cell astrocytoma include:
| Anatomical Location | Summary |
|---|---|
 |
Microscopic pathology
On microscopic histopathological analysis, subependymal giant cell astrocytoma is characterized by:
According to the WHO classification of tumors of the central nervous system, subependymal giant cell astrocytoma is classified into a WHO grade I tumor.
Immunohistochemistry
Subependymal giant cell astrocytoma is demonstrated by positivity to tumor markers such as:
Reference
- ↑ Associations of pilocytic astrocytoma. Dr Bruno Di Muzio and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/pilocytic-astrocytoma. Accessed on October 26, 2015
- ↑ "Non-random aneuploidy specifies subgroups of pilocytic astrocytoma and correlates with older age". Oncotarget. 2015. doi:10.18632/oncotarget.5571. ISSN 1949-2553.