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Image:Subependymal giant cell astrocytoma MRI 1.jpg|<sub>Two girls ([A] 9 and [B] 12 years old) with acute headaches and vomiting. On examination, both had papilledema. Brain magnetic resonance imaging shows ventricular subependymal giant cell astrocytomas with secondary hydrocephalus.<ref name="RothRoach2013">{{cite journal|last1=Roth|first1=Jonathan|last2=Roach|first2=E. Steve|last3=Bartels|first3=Ute|last4=Jóźwiak|first4=Sergiusz|last5=Koenig|first5=Mary Kay|last6=Weiner|first6=Howard L.|last7=Franz|first7=David N.|last8=Wang|first8=Henry Z.|title=Subependymal Giant Cell Astrocytoma: Diagnosis, Screening, and Treatment. Recommendations From the International Tuberous Sclerosis Complex Consensus Conference 2012|journal=Pediatric Neurology|volume=49|issue=6|year=2013|pages=439–444|issn=08878994|doi=10.1016/j.pediatrneurol.2013.08.017}}</ref></sub>
Image:Subependymal giant cell astrocytoma MRI 1.jpg|<sub>Two girls ([A] 9 and [B] 12 years old) with acute headaches and vomiting. On examination, both had papilledema. Brain magnetic resonance imaging shows ventricular subependymal giant cell astrocytomas with secondary hydrocephalus.<ref name="RothRoach2013">{{cite journal|last1=Roth|first1=Jonathan|last2=Roach|first2=E. Steve|last3=Bartels|first3=Ute|last4=Jóźwiak|first4=Sergiusz|last5=Koenig|first5=Mary Kay|last6=Weiner|first6=Howard L.|last7=Franz|first7=David N.|last8=Wang|first8=Henry Z.|title=Subependymal Giant Cell Astrocytoma: Diagnosis, Screening, and Treatment. Recommendations From the International Tuberous Sclerosis Complex Consensus Conference 2012|journal=Pediatric Neurology|volume=49|issue=6|year=2013|pages=439–444|issn=08878994|doi=10.1016/j.pediatrneurol.2013.08.017}}</ref></sub>
Image:Subependymal giant cell astrocytoma MRI 2.jpg|<sub>This 6-year-old girl had a growing but asymptomatic tumor. (A) Her screening magnetic resonance imaging at age 2 revealed a subependymal giant cell astrocytoma with mild enlargement of the right lateral ventricle. (B) By age 6 years, the lesion had enlarged markedly.<ref name="RothRoach2013">{{cite journal|last1=Roth|first1=Jonathan|last2=Roach|first2=E. Steve|last3=Bartels|first3=Ute|last4=Jóźwiak|first4=Sergiusz|last5=Koenig|first5=Mary Kay|last6=Weiner|first6=Howard L.|last7=Franz|first7=David N.|last8=Wang|first8=Henry Z.|title=Subependymal Giant Cell Astrocytoma: Diagnosis, Screening, and Treatment. Recommendations From the International Tuberous Sclerosis Complex Consensus Conference 2012|journal=Pediatric Neurology|volume=49|issue=6|year=2013|pages=439–444|issn=08878994|doi=10.1016/j.pediatrneurol.2013.08.017}}</ref></sub>
Image:Subependymal giant cell astrocytoma MRI 2.jpg|<sub>This 6-year-old girl had a growing but asymptomatic tumor. (A) Her screening magnetic resonance imaging at age 2 revealed a subependymal giant cell astrocytoma with mild enlargement of the right lateral ventricle. (B) By age 6 years, the lesion had enlarged markedly.<ref name="RothRoach2013">{{cite journal|last1=Roth|first1=Jonathan|last2=Roach|first2=E. Steve|last3=Bartels|first3=Ute|last4=Jóźwiak|first4=Sergiusz|last5=Koenig|first5=Mary Kay|last6=Weiner|first6=Howard L.|last7=Franz|first7=David N.|last8=Wang|first8=Henry Z.|title=Subependymal Giant Cell Astrocytoma: Diagnosis, Screening, and Treatment. Recommendations From the International Tuberous Sclerosis Complex Consensus Conference 2012|journal=Pediatric Neurology|volume=49|issue=6|year=2013|pages=439–444|issn=08878994|doi=10.1016/j.pediatrneurol.2013.08.017}}</ref></sub>
Image:Subependymal giant cell astrocytoma MRI 3.jpg|<sub>Subependymal giant cell astrocytoma of the type associated with tuberous sclerosis are typically bulky, contrast-enhancing mass in the region of the foramen of Monro. Most overlie the head of the caudate nucleus. Foramen obstruction has produced hydrocephalus.<ref name=Radiologyfeaturesofsega1>Radiology features of subependymal giant cell astrocytoma. Libre pathology 2015. http://librepathology.org/wiki/index.php/Subependymal_giant_cell_astrocytoma. Accessed on November 2, 2015</ref>
Image:Subependymal giant cell astrocytoma MRI 3.jpg|<sub>Subependymal giant cell astrocytoma of the type associated with tuberous sclerosis are typically bulky, contrast-enhancing mass in the region of the foramen of Monro. Most overlie the head of the caudate nucleus. Foramen obstruction has produced hydrocephalus.<ref name=Radiologyfeaturesofsega1>Radiology features of subependymal giant cell astrocytoma. Libre pathology 2015. http://librepathology.org/wiki/index.php/Subependymal_giant_cell_astrocytoma. Accessed on November 2, 2015</ref></sub>


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Revision as of 05:30, 6 November 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Overview

Brain MRI is helpful in the diagnosis of subependymal giant cell astrocytoma. On MRI, subependymal giant cell astrocytoma is characterized by hypo- to isointense on T1-weighted imaging and hyperintense on T2-weighted imaging. There may be marked enhancement on contrast administration.[1]

MRI

  • Brain MRI may be helpful in the diagnosis of subependymal giant cell astrocytoma.
  • Findings on MRI suggestive of subependymal giant cell astrocytoma are tabulated below:[1]
MRI component Findings

T1

  • Heterogenous and hypo- to isointense to grey matter

T2

  • Heterogenous and hyperintense to grey matter
  • Calcified components can be hypointense

T1 with gadolinium contrast

  • Marked homogenous or heterogenous enhancement
  • Other findings on MRI suggestive of subependymal giant cell astrocytoma include:[2]
    • Calcification around the rim of the tumor (punctuate or nodular)
    • Small cysts

Gallery

  • Two girls ([A] 9 and [B] 12 years old) with acute headaches and vomiting. On examination, both had papilledema. Brain magnetic resonance imaging shows ventricular subependymal giant cell astrocytomas with secondary hydrocephalus.[3]
    Two girls ([A] 9 and [B] 12 years old) with acute headaches and vomiting. On examination, both had papilledema. Brain magnetic resonance imaging shows ventricular subependymal giant cell astrocytomas with secondary hydrocephalus.[3]
  • This 6-year-old girl had a growing but asymptomatic tumor. (A) Her screening magnetic resonance imaging at age 2 revealed a subependymal giant cell astrocytoma with mild enlargement of the right lateral ventricle. (B) By age 6 years, the lesion had enlarged markedly.[3]
    This 6-year-old girl had a growing but asymptomatic tumor. (A) Her screening magnetic resonance imaging at age 2 revealed a subependymal giant cell astrocytoma with mild enlargement of the right lateral ventricle. (B) By age 6 years, the lesion had enlarged markedly.[3]
  • Subependymal giant cell astrocytoma of the type associated with tuberous sclerosis are typically bulky, contrast-enhancing mass in the region of the foramen of Monro. Most overlie the head of the caudate nucleus. Foramen obstruction has produced hydrocephalus.[4]
    Subependymal giant cell astrocytoma of the type associated with tuberous sclerosis are typically bulky, contrast-enhancing mass in the region of the foramen of Monro. Most overlie the head of the caudate nucleus. Foramen obstruction has produced hydrocephalus.[4]

Reference

  1. ↑ 1.0 1.1 Radiographic MRI features of subependymal giant cell astrocytoma. Dr Bruno Di Muzio and Dr Jeremy Jones et al. Radiopaedia 2015. http://radiopaedia.org/articles/subependymal-giant-cell-astrocytoma. Accessed on November 4, 2015
  2. ↑ Ouyang, Taohui; Zhang, Na; Benjamin, Thomas; Wang, Long; Jiao, Jiantong; Zhao, Yiqing; Chen, Jian (2014). "Subependymal giant cell astrocytoma: current concepts, management, and future directions". Child's Nervous System. 30 (4): 561–570. doi:10.1007/s00381-014-2383-x. ISSN 0256-7040.
  3. ↑ 3.0 3.1 Roth, Jonathan; Roach, E. Steve; Bartels, Ute; Jóźwiak, Sergiusz; Koenig, Mary Kay; Weiner, Howard L.; Franz, David N.; Wang, Henry Z. (2013). "Subependymal Giant Cell Astrocytoma: Diagnosis, Screening, and Treatment. Recommendations From the International Tuberous Sclerosis Complex Consensus Conference 2012". Pediatric Neurology. 49 (6): 439–444. doi:10.1016/j.pediatrneurol.2013.08.017. ISSN 0887-8994.
  4. ↑ Radiology features of subependymal giant cell astrocytoma. Libre pathology 2015. http://librepathology.org/wiki/index.php/Subependymal_giant_cell_astrocytoma. Accessed on November 2, 2015


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