Salivary gland tumor pathophysiology: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Salivary gland tumor}} | {{Salivary gland tumor}} | ||
{{CMG}}{{AE}}{{Simrat}} | |||
==Overview== | |||
The pathophysiology of salivary gland tumors depends on the histological subtype. | |||
==Pathophysiology== | |||
{| style="border: 0px; font-size: 90%; margin: 3px; width: 800px;" align=center | |||
|valign=top| | |||
|+ | |||
! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Entity}} | |||
! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Architecture}} | |||
! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Morphology}} | |||
! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Cell borders}} | |||
! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Cytoplasm}} | |||
! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Nucleus}} | |||
! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Differential Diagnosis}} | |||
! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Other}} | |||
|- | |||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |Pleomorphic adenoma | |||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |Variable | |||
| style="padding: 5px 5px; background: #F5F5F5;" |mixed proportion; must include: | |||
*myoepithelium | |||
*mesenchymal stroma | |||
*epithelium (ductal cells) or | |||
*chondromyxoid stroma | |||
| style="padding: 5px 5px; background: #F5F5F5;" |Variable | |||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |Variable | |||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |Plasmacytoid | |||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |Adenoid cystic carcinoma | |||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |Occasionally encapsulated, mixed proportion of glandular, myoepithelial and mesenchymal cells | |||
|- | |||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |Warthin tumor | |||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |Papillary, bilayer | |||
| style="padding: 5px 5px; background: #F5F5F5;" |Cuboid (basal), columnar (apical) | |||
| style="padding: 5px 5px; background: #F5F5F5;" |Clearly seen | |||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |Eosinophilic, abundant | |||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |Unremarkable | |||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |Sebaceous lymphadenoma | |||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |AKA papillary cystadenoma lymphomatosum | |||
|- | |||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |Basal cell adenoma | |||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |variable, islands surrounded by hyaline bands, lesion encapsulated | |||
| style="padding: 5px 5px; background: #F5F5F5;" |Basaloid | |||
| style="padding: 5px 5px; background: #F5F5F5;" |Subtle | |||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |Scant, hyperchromatic | |||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |Granular | |||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |Basal cell adenocarcinoma | |||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | | |||
|- | |||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |Canalicular adenoma | |||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |Chains of cells | |||
| style="padding: 5px 5px; background: #F5F5F5;" |Cuboid or columnar | |||
| style="padding: 5px 5px; background: #F5F5F5;" |Subtle | |||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |Scant, hyperchromatic | |||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |Granular | |||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |Basal cell adenoma | |||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |Exclusively oral cavity, 80% in upper lip; immunohistochemistry: p63- | |||
|- | |||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |Sialoblastoma | |||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |variable, islands surrounded by loose fibrous stroma | |||
| style="padding: 5px 5px; background: #F5F5F5;" |Basaloid | |||
| style="padding: 5px 5px; background: #F5F5F5;" |Subtle | |||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |Scant, hyperchromatic | |||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |Granular | |||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |Adenoid cystic carcinoma | |||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |Basal cell adenocarcinoma | |||
|- | |||
|} | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} |
Revision as of 03:57, 8 November 2015
Salivary gland tumor Microchapters |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]
Overview
The pathophysiology of salivary gland tumors depends on the histological subtype.
Pathophysiology
Entity | Architecture | Morphology | Cell borders | Cytoplasm | Nucleus | Differential Diagnosis | Other |
---|---|---|---|---|---|---|---|
Pleomorphic adenoma | Variable | mixed proportion; must include:
|
Variable | Variable | Plasmacytoid | Adenoid cystic carcinoma | Occasionally encapsulated, mixed proportion of glandular, myoepithelial and mesenchymal cells |
Warthin tumor | Papillary, bilayer | Cuboid (basal), columnar (apical) | Clearly seen | Eosinophilic, abundant | Unremarkable | Sebaceous lymphadenoma | AKA papillary cystadenoma lymphomatosum |
Basal cell adenoma | variable, islands surrounded by hyaline bands, lesion encapsulated | Basaloid | Subtle | Scant, hyperchromatic | Granular | Basal cell adenocarcinoma | |
Canalicular adenoma | Chains of cells | Cuboid or columnar | Subtle | Scant, hyperchromatic | Granular | Basal cell adenoma | Exclusively oral cavity, 80% in upper lip; immunohistochemistry: p63- |
Sialoblastoma | variable, islands surrounded by loose fibrous stroma | Basaloid | Subtle | Scant, hyperchromatic | Granular | Adenoid cystic carcinoma | Basal cell adenocarcinoma |