Salivary gland tumor pathophysiology: Difference between revisions

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Revision as of 23:22, 13 November 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]

Overview

The pathophysiology of salivary gland tumors depends on the histological subtype.^[1]

Pathophysiology

Histological features of benign tumors


Entity	Architecture	Morphology	Cell borders	Cytoplasm	Nucleus	Differential Diagnosis	Other

Pleomorphic adenoma	Variable	Mixed proportion; must include: Myoepithelium Mesenchymal stroma Epithelium (ductal cells) or Chondromyxoid stroma	Variable	Variable	Plasmacytoid	Adenoid cystic carcinoma	Occasionally encapsulated, mixed proportion of glandular, myoepithelial and mesenchymal cells
Warthin tumor	Papillary, bilayer	Cuboid (basal), columnar (apical)	Clearly seen	Eosinophilic, abundant	Unremarkable	Sebaceous lymphadenoma	AKA papillary cystadenoma lymphomatosum
Basal cell adenoma	Variable, islands surrounded by hyaline bands, lesion encapsulated	Basaloid	Subtle	Scant, hyperchromatic	Granular	Basal cell adenocarcinoma
Canalicular adenoma	Chains of cells	Cuboid or columnar	Subtle	Scant, hyperchromatic	Granular	Basal cell adenoma	Exclusively oral cavity, 80% in upper lip; immunohistochemistry: p63-
Sialoblastoma	Variable, islands surrounded by loose fibrous stroma	Basaloid	Subtle	Scant, hyperchromatic	Granular	Adenoid cystic carcinoma	Basal cell adenocarcinoma

Histological features of malignant tumors


Entity	Architecture	Morphology	Cell borders	Cytoplasm	Nucleus	Differential Diagnosis	Other

Mucoepidermoid carcinoma	Cystic and solid	Epitheloid	Distinct	Fuffy, clear, abundant	Nuclei small	SCC (?)	Immunohistochemistry: p63+
Adenoid cystic carcinoma (AdCC)	Pseudocysts, cribriform, solid, hyaline stroma	Epitheloid	Subtle	Scant, hyperchromatic	Small+/-"carrot-shaped"	Pleomorphic adenoma, Polymorphous low grade adenocarcinoma (PLGA)	Stains: PAS+ (pseudocyst material), CD117+, cyclin D1+
Acinic cell carcinoma (AcCC)	Sheets, acinar (islands)	Epithelioid	Clear	Granular abundant	Stippled, +/-occasional nucleoli	Adenocarcinoma not otherwise specified, oncocytoma of salivary gland	Stains: PAS +ve, PAS-D +ve; Immunohistochemistry: S-100 -ve, p63 -ve
Salivary duct carcinoma	Glandular, cribriform	Columnar	Subtle/clear	Hyperchromatic	Columnar	Metastatic breast carcinoma	Similar to ductal breast carcinoma; male>female
Polymorphous low-grade adenocarcinoma	Variable, often small nests, may be targetoid	Epithelioid	Indistinct	Eosinophilic	Ovoid & small with small nucleoli	Adenoid cystic carcinoma (AdCC)	minor salivary gland tumour, often in palate, cytologically monotonous; IHC: S-100+, CK+, vim.+, GFAP+/-, BCL2+/-
Epithelial-myoepithelial carcinoma	Nests (myoepithelial) with tubules (epithelial)	Epithelioid	Not distinct	Eosinophilic cytoplasm; epithelial: scant; myoepithelial: moderate	Focal clearing	Adenoid cystic carcinoma (AdCC), pleomorphic adenoma	Rare
Basal cell adenocarcinoma	Variable, islands surrounded by hyaline bands, lesion not encapsulated	Basaloid	Subtle	Scant, hyperchromatic	Granular	Basal cell adenoma	Rare, usually parotid gland, may arise from a basal cell adenoma

Polymorphous low-grade adenocarcinoma
Warthin tumor
Adenoid cystic carcinoma
Basal cell adenocarcinoma
Epithelial-myoepithelial carcinoma
Salivary duct carcinoma
Mucoepidermoid carcinoma
Pleomorphic adenoma
Acinic cell carcinoma

References

↑ Salivary glands. Libre pathology(2015) http://librepathology.org/wiki/index.php/Salivary_glands Accessed on November 11, 2015

Template:WikiDoc Sources

[librepathology-1] Salivary glands. Libre pathology(2015) http://librepathology.org/wiki/index.php/Salivary_glands Accessed on November 11, 2015

[1]

@@ Line 22: / Line 22: @@
 | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |Pleomorphic adenoma
 | style="padding: 5px 5px; background:  #F5F5F5;"   |Variable
-| style="padding: 5px 5px; background:  #F5F5F5;"   |mixed proportion; must include:
+| style="padding: 5px 5px; background:  #F5F5F5;"   |Mixed proportion; must include:
-*myoepithelium
+*Myoepithelium
-*mesenchymal stroma
+*Mesenchymal stroma
-*epithelium (ductal cells) or
+*Epithelium (ductal cells) or
-*chondromyxoid stroma
+*Chondromyxoid stroma
 | style="padding: 5px 5px; background:  #F5F5F5;"  |Variable
 | style="padding: 5px 5px; background:  #F5F5F5;"  |Variable
@@ Line 43: / Line 43: @@
 |-
 | style="padding: 5px 5px; background:  #DCDCDC;  font-weight: bold"  |Basal cell adenoma
-| style="padding: 5px 5px; background:  #F5F5F5;"   |variable, islands surrounded by hyaline bands, lesion encapsulated
+| style="padding: 5px 5px; background:  #F5F5F5;"   |Variable, islands surrounded by hyaline bands, lesion encapsulated
 | style="padding: 5px 5px; background:  #F5F5F5;"   |Basaloid
 | style="padding: 5px 5px; background:  #F5F5F5;"   |Subtle
@@ Line 61: / Line 61: @@
 |-
 | style="padding: 5px 5px; background:  #DCDCDC;  font-weight: bold" |Sialoblastoma
-| style="padding: 5px 5px; background:  #F5F5F5;"  |variable, islands surrounded by loose fibrous stroma
+| style="padding: 5px 5px; background:  #F5F5F5;"  |Variable, islands surrounded by loose fibrous stroma
 | style="padding: 5px 5px; background:  #F5F5F5;"  |Basaloid
 | style="padding: 5px 5px; background:  #F5F5F5;"   |Subtle
@@ Line 89: / Line 89: @@
 | style="padding: 5px 5px; background:  #F5F5F5;"  |Epitheloid
 | style="padding: 5px 5px; background:  #F5F5F5;"  |Distinct
-| style="padding: 5px 5px; background:  #F5F5F5;"  |fuffy, clear, abundant
+| style="padding: 5px 5px; background:  #F5F5F5;"  |Fuffy, clear, abundant
 | style="padding: 5px 5px; background:  #F5F5F5;"  |Nuclei small
 | style="padding: 5px 5px; background:  #F5F5F5;"  |SCC (?)
@@ Line 95: / Line 95: @@
 |-
 | style="padding: 5px 5px; background: #DCDCDC;  font-weight: bold" |Adenoid cystic carcinoma (AdCC)
-| style="padding: 5px 5px; background:  #F5F5F5;" |pseudocysts, cribriform, solid, hyaline stroma
+| style="padding: 5px 5px; background:  #F5F5F5;" |Pseudocysts, cribriform, solid, hyaline stroma
 | style="padding: 5px 5px; background:  #F5F5F5;" |Epitheloid
 | style="padding: 5px 5px; background:  #F5F5F5;" |Subtle
@@ Line 108: / Line 108: @@
 | style="padding: 5px 5px; background:  #F5F5F5;"   |Clear
 | style="padding: 5px 5px; background:  #F5F5F5;"   |Granular abundant
-| style="padding: 5px 5px; background:  #F5F5F5;"   |stippled, +/-occasional nucleoli
+| style="padding: 5px 5px; background:  #F5F5F5;"   |Stippled, +/-occasional nucleoli
 | style="padding: 5px 5px; background:  #F5F5F5;"   |Adenocarcinoma not otherwise specified, oncocytoma of salivary gland
 | style="padding: 5px 5px; background:  #F5F5F5;"   |Stains: PAS +ve, PAS-D +ve; Immunohistochemistry: S-100 -ve, p63 -ve
@@ Line 119: / Line 119: @@
 | style="padding: 5px 5px; background:  #F5F5F5;"   |Columnar
 | style="padding: 5px 5px; background:  #F5F5F5;"  |Metastatic breast carcinoma
-| style="padding: 5px 5px; background:  #F5F5F5;"   |similar to ductal breast carcinoma; male>female
+| style="padding: 5px 5px; background:  #F5F5F5;"   |Similar to ductal breast carcinoma; male>female
 |-
 | style="padding: 5px 5px; background:  #DCDCDC;  font-weight: bold" |Polymorphous low-grade adenocarcinoma
@@ Line 157: / Line 157: @@
 px-Salivary duct carcinoma -a- low mag.jpg|Salivary duct carcinoma
 Mucoepidermoid carcinoma (2) HE stain (1).jpg|Mucoepidermoid carcinoma
-Pleomorphic adenoma (1) parotid gland.jpg|pleomorphic adenoma
+Pleomorphic adenoma (1) parotid gland.jpg|Pleomorphic adenoma
 px-Acinic cell carcinoma - high mag.jpg|Acinic cell carcinoma
 </gallery>
@@ Line 167: / Line 167: @@
 [[Category:Types of cancer]]
 [[Category:Disease]]
-[[Category:Salivary gland neoplasia]]
+[[Category:Rare cancers]]

Salivary gland tumor pathophysiology: Difference between revisions

Revision as of 23:22, 13 November 2015

Overview

Pathophysiology

Histological features of benign tumors

Histological features of malignant tumors

References

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