Atypical teratoid rhabdoid tumor differential diagnosis: Difference between revisions
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{{Atypical teratoid rhabdoid tumor}} | {{Atypical teratoid rhabdoid tumor}} | ||
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==Overview== | |||
==Differentiating Atypical Teratoid Rhabdoid Tumor from other Diseases== | ==Differentiating Atypical Teratoid Rhabdoid Tumor from other Diseases== | ||
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Revision as of 20:21, 14 December 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Differentiating Atypical Teratoid Rhabdoid Tumor from other Diseases
The critical step in treatment planning is to determine the correct histology of the tumor. Misidentification of the tumor histology can lead to errors in treatment and prognosis.[1]
Atypical teratoid/rhaboid tumor closely resembles medulloblastoma,[2] primitive neuroectodermal tumor, choroid plexus carcinoma, and some kinds of germ cell tumor. Because rhabdoid characteristics are not the only component of AT/RT, some sections of an AT/RT may resemble other tumors. These characteristics may be present only in focal areas or may be less pronounced.
It is important to consider AT/RT when a medulloblastoma or PNET is suspected, particularly in a child under the age of one. Cytogenetic studies can assist in differentiating MB/PNETs from AT/RTs. Some kinds of germ cell tumor secrete tumor markers AFP or bHCG; AT/RTs do not.
References
- ↑ Jay V, Edwards V, Halliday W, Rutka J, Lau R (1997). ""Polyphenotypic" tumors in the central nervous system: problems in nosology and classification". Pediatr Pathol Lab Med. 17 (3): 369–89. PMID 9185218.
- ↑ Burger PC, Yu IT, Tihan T; et al. (1998). "Atypical teratoid/rhabdoid tumor of the central nervous system: a highly malignant tumor of infancy and childhood frequently mistaken for medulloblastoma: a Pediatric Oncology Group study". Am. J. Surg. Pathol. 22 (9): 1083–92. PMID 9737241.