Paget's disease of the breast overview: Difference between revisions
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==Pathophysiology== | ==Pathophysiology== | ||
On gross pathology, [[Eczema|eczematoid]], [[Erythema|erythematous]], moist or crusted lesion, with or without fine scaling, [[Cellular infiltration|infiltration]] of the nipple, and inversion of the nipple are characteristic findings of Paget's disease of the [[breast]].<ref name="Lopes FilhoLopes2015">{{cite journal|last1=Lopes Filho|first1=Lauro Lourival|last2=Lopes|first2=Ione Maria Ribeiro Soares|last3=Lopes|first3=Lauro Rodolpho Soares|last4=Enokihara|first4=Milvia M. S. S.|last5=Michalany|first5=Alexandre Osores|last6=Matsunaga|first6=Nobuo|title=Mammary and extramammary Paget's disease|journal=Anais Brasileiros de Dermatologia|volume=90|issue=2|year=2015|pages=225–231|issn=1806-4841|doi=10.1590/abd1806-4841.20153189}}</ref> On microscopic histopathological analysis, epidermal Paget cells which are malignant glandular [[epithelial cells]] organized in groups with nest-like patterns or gland-like structures and are preferably located in the epidermal basal layer are characteristic findings of Paget's disease of the breast. | On gross pathology, [[Eczema|eczematoid]], [[Erythema|erythematous]], moist or crusted lesion, with or without fine scaling, [[Cellular infiltration|infiltration]] of the nipple, and inversion of the nipple are characteristic findings of Paget's disease of the [[breast]].<ref name="Lopes FilhoLopes2015">{{cite journal|last1=Lopes Filho|first1=Lauro Lourival|last2=Lopes|first2=Ione Maria Ribeiro Soares|last3=Lopes|first3=Lauro Rodolpho Soares|last4=Enokihara|first4=Milvia M. S. S.|last5=Michalany|first5=Alexandre Osores|last6=Matsunaga|first6=Nobuo|title=Mammary and extramammary Paget's disease|journal=Anais Brasileiros de Dermatologia|volume=90|issue=2|year=2015|pages=225–231|issn=1806-4841|doi=10.1590/abd1806-4841.20153189}}</ref> On microscopic histopathological analysis, epidermal Paget cells which are malignant glandular [[epithelial cells]] organized in groups with nest-like patterns or gland-like structures and are preferably located in the epidermal basal layer are characteristic findings of Paget's disease of the breast. | ||
==Causes== | |||
The cause of Paget's disease of the breast has not been identified. | |||
==References== | ==References== | ||
Revision as of 14:35, 15 January 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Paget's disease is an eczematous skin change of the nipple that is usually associated with an underlying breast malignancy. The condition was first described in 1874 by the surgeon, Sir James Paget, who noted that the chronic eczematous rash of the nipple preceded an underlying intraductal carcinoma.[1]Paget's disease of the breast, also known as Paget's disease of the nipple, is a condition that outwardly may have the appearance of eczema - with skin changes involving the nipple of the breast. Because of its seemingly innocuous and surface appearance, it often presents late, but it is a condition that may be fatal. Extramammary Paget's disease (EMPD) has the same histologic features as Paget's disease of the breast but different locations.
Historical Perspective
Paget's disease of the breast was first discovered by James Paget, a British surgeon and physiologist, in 1874.[2]
Classification
There is no classification system established for Paget's disease of the breast.
Pathophysiology
On gross pathology, eczematoid, erythematous, moist or crusted lesion, with or without fine scaling, infiltration of the nipple, and inversion of the nipple are characteristic findings of Paget's disease of the breast.[2] On microscopic histopathological analysis, epidermal Paget cells which are malignant glandular epithelial cells organized in groups with nest-like patterns or gland-like structures and are preferably located in the epidermal basal layer are characteristic findings of Paget's disease of the breast.
Causes
The cause of Paget's disease of the breast has not been identified.
References
- ↑ Fouad, Dina (2011). "Paget's disease of the breast in a male with lymphomatoid papulosis: a case report". Journal of Medical Case Reports. 5 (1): 43. doi:10.1186/1752-1947-5-43. ISSN 1752-1947.
- ↑ 2.0 2.1 Lopes Filho, Lauro Lourival; Lopes, Ione Maria Ribeiro Soares; Lopes, Lauro Rodolpho Soares; Enokihara, Milvia M. S. S.; Michalany, Alexandre Osores; Matsunaga, Nobuo (2015). "Mammary and extramammary Paget's disease". Anais Brasileiros de Dermatologia. 90 (2): 225–231. doi:10.1590/abd1806-4841.20153189. ISSN 1806-4841.