Sandbox: Kaposi: Difference between revisions

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! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|Histologic Features}}
! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|Histologic Features}}
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'''Macular stage'''  
'''Macular stage'''  
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Thin-walled, angulated vessels throughout dermis, with hemosiderin and plasma cell infiltrate
* Thin vessel wall
* Angulated vessels throughout dermis
* Plasma cell and hemosiderin infiltrates
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'''Patch stage'''
'''Patch stage'''
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Angulated lumina that dissect dermal collagen
* Angulated lumina that dissect dermal collagen
Vessels may proliferate around well-developed round venules (premonitory sign)
* Premonitory sign
Angiomatoid vascular spaces with red blood cells are surrounded by spindle cells in short fascicles
* Spindle cells surround angiomatoid vascular spaces filled with RBC
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'''Tumor stage'''  
'''Tumor stage'''  
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Solid nodules with extensive spindle cells and red blood cells in slit-like lumina
* Solid nodules  
No/rare mitotic activity or atypia
* The presence of spindle cells and red blood cells in a slit-like lumina
* Abscence of cellular atypia or mitotic activity  
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'''Lymphangioma-like variant'''  
'''Lymphangioma-like variant'''  
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Thin, angulated vessels with no red blood cells
* Thin walled, angulated vessels
* Absence of red blood cells
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Latest revision as of 17:21, 19 January 2016
Clincal Stage Histologic Features

Macular stage

  • Thin vessel wall
  • Angulated vessels throughout dermis
  • Plasma cell and hemosiderin infiltrates

Patch stage

  • Angulated lumina that dissect dermal collagen
  • Premonitory sign
  • Spindle cells surround angiomatoid vascular spaces filled with RBC

Tumor stage

  • Solid nodules
  • The presence of spindle cells and red blood cells in a slit-like lumina
  • Abscence of cellular atypia or mitotic activity

Lymphangioma-like variant

  • Thin walled, angulated vessels
  • Absence of red blood cells
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