Aspergillosis laboratory findings: Difference between revisions
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{{CMG}}; {{AE}} {{HL}}; {{YD}}; {{SSK}} | {{CMG}}; {{AE}} {{HL}}; {{YD}}; {{SSK}} | ||
==Overview== | ==Overview== | ||
Laboratory findings consistent with the diagnosis of aspergillosis include positive aspergillus antibody test, positive [[galactomannan]] test, | Laboratory findings consistent with the diagnosis of aspergillosis include positive aspergillus antibody test, positive [[galactomannan]] test, elevated concentration of [[IgE]] [[immunoglobulin]], and positive culture from [[sputum]] or [[bronchoalveolar lavage]].<ref name="wiki">Aspergillosis. Wikipedia (2015) https://en.wikipedia.org/wiki/Aspergillosis#Diagnosis Accessed on February, 8 2016</ref><ref name="pmid21177400">{{cite journal| author=Cuenca-Estrella M, Bassetti M, Lass-Flörl C, Rácil Z, Richardson M, Rogers TR| title=Detection and investigation of invasive mould disease. | journal=J Antimicrob Chemother | year= 2011 | volume= 66 Suppl 1 | issue= | pages= i15-24 | pmid=21177400 | doi=10.1093/jac/dkq438 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21177400 }} </ref><ref name="pmid18384212">{{cite journal| author=Kradin RL, Mark EJ| title=The pathology of pulmonary disorders due to Aspergillus spp. | journal=Arch Pathol Lab Med | year= 2008 | volume= 132 | issue= 4 | pages= 606-14 | pmid=18384212 | doi=10.1043/1543-2165(2008)132[606:TPOPDD]2.0.CO;2 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18384212 }} </ref> | ||
==Laboratory Findings== | ==Laboratory Findings== | ||
====Complete Blood Count==== | ====Complete Blood Count==== | ||
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* Positive beta-D-glucan assay | * Positive beta-D-glucan assay | ||
====Culture==== | ====Culture==== | ||
* Positive [[sputum]] | * Positive culture and staining from [[sputum]] or from [[bronchoalveolar lavage]] (BAL) | ||
* | * Culture can be performed on a variety of [[sterile]] specimens. [[Aspergillus]] spp. typically appear as rapidly growing [[mold]]s that are visible 1-3 days following incubation. | ||
* | * Patients with invasive aspergillosis may have negative cultures. | ||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
[[Category:Fungal diseases]] | [[Category:Fungal diseases]] | ||
[[Category:Infectious disease]] | [[Category:Infectious disease]] | ||
Revision as of 23:51, 8 February 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]; Yazan Daaboul, M.D.; Serge Korjian M.D.
Overview
Laboratory findings consistent with the diagnosis of aspergillosis include positive aspergillus antibody test, positive galactomannan test, elevated concentration of IgE immunoglobulin, and positive culture from sputum or bronchoalveolar lavage.[1][2][3]
Laboratory Findings
Complete Blood Count
Electrophoresis
- Elevated concentration of serum immunoglobulin E (IgE)
Biomarkers
- Positive galactomannan assay
- Positive beta-D-glucan assay
Culture
- Positive culture and staining from sputum or from bronchoalveolar lavage (BAL)
- Culture can be performed on a variety of sterile specimens. Aspergillus spp. typically appear as rapidly growing molds that are visible 1-3 days following incubation.
- Patients with invasive aspergillosis may have negative cultures.
References
- ↑ Aspergillosis. Wikipedia (2015) https://en.wikipedia.org/wiki/Aspergillosis#Diagnosis Accessed on February, 8 2016
- ↑ Cuenca-Estrella M, Bassetti M, Lass-Flörl C, Rácil Z, Richardson M, Rogers TR (2011). "Detection and investigation of invasive mould disease". J Antimicrob Chemother. 66 Suppl 1: i15–24. doi:10.1093/jac/dkq438. PMID 21177400.
- ↑ Kradin RL, Mark EJ (2008). "The pathology of pulmonary disorders due to Aspergillus spp". Arch Pathol Lab Med. 132 (4): 606–14. doi:10.1043/1543-2165(2008)132[606:TPOPDD]2.0.CO;2. PMID 18384212.