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The table below summarizes the classification of bone and cartilage tumors according to tumor origin and location.<ref name="bone1"> Bone tumors. https://en.wikipedia.org/wiki/Bone_tumor Accessed on February 2, 2016</ref><ref name="bone2">Alina Maria Sisu. On the Bone Tumours: Overview, Classification, Incidence, Histopathological Issues, Behavior and Review Using Literature Data. http://www.intechopen.com/books/histopathology-reviews-and-recent-advances/on-the-bone-tumours-overview-classification-incidence-histopathological-issues-behavior-and-review Accessed on February 2, 2016 </ref>
The table below summarizes the classification of bone and cartilage tumors according to histopathological origin, tumor location, and tumor nature.<ref name="bone1"> Bone tumors. https://en.wikipedia.org/wiki/Bone_tumor Accessed on February 2, 2016</ref><ref name="bone2">Alina Maria Sisu. On the Bone Tumours: Overview, Classification, Incidence, Histopathological Issues, Behavior and Review Using Literature Data. http://www.intechopen.com/books/histopathology-reviews-and-recent-advances/on-the-bone-tumours-overview-classification-incidence-histopathological-issues-behavior-and-review Accessed on February 2, 2016 </ref>


{| class="wikitable"
{| style="border: 0px; font-size: 90%; margin: 3px; width: 1000px" align=center
! colspan="3" style="text-align: center; font-weight: bold;" | Bone or cartilage mass classification
|valign=top|
<SMALL>Adapted from ICD-10/WHO (9180–9269)<br><ref name="pmid18223119">{{cite journal |vauthors=Miller TT |title=Bone tumors and tumorlike conditions: analysis with conventional radiography |journal=Radiology |volume=246 |issue=3 |pages=662–74 |year=2008 |pmid=18223119 |doi=10.1148/radiol.2463061038 |url=}}</ref></SMALL>
|+
!style="padding: 0 5px; background: #DCDCDC" colspan=5|{{fontcolor|#000| Bone or cartilage mass classification <br> <SMALL> Adapted from ICD-10/WHO (9180–9269)<ref name="pmid18223119">{{cite journal |vauthors=Miller TT |title=Bone tumors and tumorlike conditions: analysis with conventional radiography |journal=Radiology |volume=246 |issue=3 |pages=662–74 |year=2008 |pmid=18223119 |doi=10.1148/radiol.2463061038 |url=}}</ref></SMALL>}}
|-
|-
| style="text-align: center;" | '''Location'''
!style="background: #4479BA; width: 200px;" |{{fontcolor|#FFF|Osteogenic tumors: bone-forming tumors}}
| style="text-align: center;" | '''Origin'''
!style="background: #4479BA; width: 200px;" |{{fontcolor|#FFF|Cartilage tumors: cartilage-forming tumors}}
| style="text-align: center;" | '''Type of tumor'''
!style="background: #4479BA; width: 200px;" |{{fontcolor|#FFF|Fibrogenic or fibrohistiocytic tumors}}
!style="background: #4479BA; width: 200px;" |{{fontcolor|#FFF|Cystic tumors}}
!style="background: #4479BA; width: 400px;" |{{fontcolor|#FFF|Others ( hematopoietic, notochordal, neuroectodermal)}}
|-
|-
| rowspan="3" style="text-align: center;" | '''Diaphysis'''
| style="padding: 0 5px; background: #DCDCDC" colspan=5 |{{fontcolor|#000|'''Histological Type'''}}
| Myeloid
| Multiple myeloma
|-
|-
| Epithelial
| style="text-align: left;" |
| Adamantinoma
*Osteoid osteoma
*Osteoblastoma
*Osteoma
*Osteosarcoma
| style="text-align: left;" |
*Osteochondroma
*Chondroblastoma
*Enchondroma
*Chondromyxoid fibroma
| style="text-align: left;" |
*Desmoplastic fibroma
*Fibrous dysplasia
*Ossyifing fibroma
*Non-ossifying fibroma
| style="text-align: left;" |
*Unicameral bone cyst
*Aneurysmal bone cyst
| style="text-align: left;" |
*Giant cell tumor
*Adamantimoma
*Eosinophilic granuloma
*Ewing sarcoma
*Metastases
|-
|-
| PNET/Ewing family
!style="background: #4479BA; width: 300px;" colspan=2|{{fontcolor|#FFF|Epiphysis}}
| Ewing's sarcoma
!style="background: #4479BA; width: 300px;" |{{fontcolor|#FFF|Diaphysis}}
!style="background: #4479BA; width: 100px;" colspan=2|{{fontcolor|#FFF|Metaphysis}}
|-
|-
| rowspan="10" style="text-align: center;" | '''Metaphysis'''
|style="padding: 0 5px; background: #DCDCDC" colspan=5 |{{fontcolor|#000| '''Tumor Location'''}}
| rowspan="3" | Osteoblast
| Osteoid osteoma
|-
|-
| Osteoblastoma
| style="text-align: left;"colspan=2 |
*Chondroblastoma
*Giant cell tumor
*Intraosseous ganglion
*Chondrosarcoma
*Metastases
*Ewing's sarcoma
| style="text-align: left;"colspan=2 |
| style="text-align: left;"colspan=2 |
 
*Eosinophilic granuloma
*Ewing sarcoma
*Myeloma
*Metastases
*Adamantimoma
*Ossyfing fibroma
*Enchondroma
| style="text-align: lwdr;" colspan=2|
*Osteosarcoma
*Chondromyxoid fibroma
*Unicameral bone cyst
*Osteoid osteoma
*Metastases
|-
|-
| Osteoma/osteosarcoma
!style="background: #4479BA; width: 300px;" colspan=3|{{fontcolor|#FFF|Benign}}
!style="background: #4479BA; width: 100px;" colspan=2|{{fontcolor|#FFF|Malignant}}
|-
|-
| rowspan="5" | Chondroblast
|style="padding: 0 5px; background: #DCDCDC" colspan=5 |{{fontcolor|#000| '''Tumor Nature'''}}
| Chondroma/ecchondroma/enchondroma
|-
|-
| Enchondromatosis
| style="text-align: left;" colspan=3 |
*Osteoid osteoma
*Enchondroma
*Chondromyxoid fibroma
*Ossifying fibroma
*Osteoblastoma
*Unicameral bone cyst
*Aneursymal bone cyst
*Giant cell tumor
*Osteochondroma
| style="text-align: left;" colspan=2 |
*Osteosarcoma
*Ewing sarcoma
*Chondrosarcoma
*Fibrosarcoma
*Malignant fibrous histiocytoma
*Plasma cell myeloma
*Metastases
|-
|-
| Chondrosarcoma
|-
| Osteochondroma
|-
| Chondromyxoid fibroma
|-
| rowspan="2" | Fibrous
| Ossifying fibroma
|-
| Fibrosarcoma
|-
| rowspan="2" style="text-align: center;" | '''Epiphysis'''
| Chondroblast
| Chondroblastoma
|-
| Myeloid
| Giant-cell tumor of bone
|-
| style="text-align: center;" | '''Other/ungrouped'''
| Notochord
| Chordoma
|}
|}


==References==
==References==

Revision as of 19:56, 11 February 2016

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]

Overview

Bone and cartilage tumors may be classified according to the WHO histological classification system into benign and malignant tumors, and categorized into 5 sub-types: cartilage tumors, osteogenic tumors, fibrohistiocytic tumors, notochordal tumors, hematopoietic tumors, and miscellaneous tumors.[1][2] In addition, bone and cartilage tumors may be sub-classified according to tumor location into 4 subtypes: diaphysis, metaphysis, epiphysis, and ungrouped/others.[3]

Classification

Bone and cartilage tumors may be classified by location, origin, and histopahological origin.

  • Tumor location
  • Diaphysis
  • Epiphysis
  • Metaphysis
  • Other/Unclassifed
  • Tumor nature
  • Benign
  • Malignant
  • Origin
  • Primary
  • Secondary
  • Histopathological origin
  • Cartilage tumors
  • Osteogenic tumors
  • Fibrohistiocytic tumors
  • Notochordal tumors
  • Hematopoietic tumors
  • Miscellaneous tumors.


The table below summarizes the classification of bone and cartilage tumors according to histopathological origin, tumor location, and tumor nature.[1][2]

Bone or cartilage mass classification
Adapted from ICD-10/WHO (9180–9269)[3]
Osteogenic tumors: bone-forming tumors Cartilage tumors: cartilage-forming tumors Fibrogenic or fibrohistiocytic tumors Cystic tumors Others ( hematopoietic, notochordal, neuroectodermal)
Histological Type
  • Osteoid osteoma
  • Osteoblastoma
  • Osteoma
  • Osteosarcoma
  • Osteochondroma
  • Chondroblastoma
  • Enchondroma
  • Chondromyxoid fibroma
  • Desmoplastic fibroma
  • Fibrous dysplasia
  • Ossyifing fibroma
  • Non-ossifying fibroma
  • Unicameral bone cyst
  • Aneurysmal bone cyst
  • Giant cell tumor
  • Adamantimoma
  • Eosinophilic granuloma
  • Ewing sarcoma
  • Metastases
Epiphysis Diaphysis Metaphysis
Tumor Location
  • Chondroblastoma
  • Giant cell tumor
  • Intraosseous ganglion
  • Chondrosarcoma
  • Metastases
  • Ewing's sarcoma
  • Eosinophilic granuloma
  • Ewing sarcoma
  • Myeloma
  • Metastases
  • Adamantimoma
  • Ossyfing fibroma
  • Enchondroma
  • Osteosarcoma
  • Chondromyxoid fibroma
  • Unicameral bone cyst
  • Osteoid osteoma
  • Metastases
Benign Malignant
Tumor Nature
  • Osteoid osteoma
  • Enchondroma
  • Chondromyxoid fibroma
  • Ossifying fibroma
  • Osteoblastoma
  • Unicameral bone cyst
  • Aneursymal bone cyst
  • Giant cell tumor
  • Osteochondroma
  • Osteosarcoma
  • Ewing sarcoma
  • Chondrosarcoma
  • Fibrosarcoma
  • Malignant fibrous histiocytoma
  • Plasma cell myeloma
  • Metastases


References

  1. ↑ 1.0 1.1 Bone tumors. https://en.wikipedia.org/wiki/Bone_tumor Accessed on February 2, 2016
  2. ↑ 2.0 2.1 Alina Maria Sisu. On the Bone Tumours: Overview, Classification, Incidence, Histopathological Issues, Behavior and Review Using Literature Data. http://www.intechopen.com/books/histopathology-reviews-and-recent-advances/on-the-bone-tumours-overview-classification-incidence-histopathological-issues-behavior-and-review Accessed on February 2, 2016
  3. ↑ 3.0 3.1 Miller TT (2008). "Bone tumors and tumorlike conditions: analysis with conventional radiography". Radiology. 246 (3): 662–74. doi:10.1148/radiol.2463061038. PMID 18223119.


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