Fibroma natural history: Difference between revisions
Simrat Sarai (talk | contribs) |
Simrat Sarai (talk | contribs) |
||
| Line 21: | Line 21: | ||
Ossifying fibromas tend to regress over time. For locally aggressive lesions, surgical resection is often curative although recurrence has been reported. | Ossifying fibromas tend to regress over time. For locally aggressive lesions, surgical resection is often curative although recurrence has been reported. | ||
==Pleural Fibroma== | ==Pleural Fibroma== | ||
The majority of pleural fibromas tend to be benign and slow growing. | *The majority of pleural fibromas tend to be benign and slow growing. Approximately 78% to 88% of SFT's are benign and 12% to 22% are malignant. In approximately 10 to 25 percent of cases recurrence of the tumor can occur. Late relapse, even for benign tumors, is common. | ||
*Approximately 63% of patients with malignant pleural fibromas will have a recurrence of their tumor, of which more than half will succumb to disease progression within 2 years. | |||
*Among tumors classified as malignant, approximately 10 to 40 percent of those destined to metastasize will do so after five years, and they may recur up to 20 years after initial presentation . Prolonged survival after pleural fibroma recurrence is possible, particularly for those who are amenable to re-resection. Patients with multiple synchronous metastases that are not amenable to surgical intervention, usually have a poor prognosis. | |||
*Recurrence in pleural fibromas may be due to following causes:\ | |||
*Incomplete resection | |||
*Tumor seeding within the pleura, peritoneum or meninges, or distant hematogenous spread. | |||
*The most common sites of distant metastasis in SFT at all sites are lung, liver, bone, and brain | |||
==Chondromyxoid-Fibroma== | ==Chondromyxoid-Fibroma== | ||
Chondromyxoid-fibroma are benign lesions and malignant degeneration is rare. Chondromyxoid-fibromas have a high recurrence rate of approximately 25%. | Chondromyxoid-fibroma are benign lesions and malignant degeneration is rare. Chondromyxoid-fibromas have a high recurrence rate of approximately 25%. | ||
Revision as of 21:37, 7 March 2016
|
Fibroma Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Fibroma natural history On the Web |
|
American Roentgen Ray Society Images of Fibroma natural history |
|
Risk calculators and risk factors for Fibroma natural history |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]
Overview
Natural History
Complications
Ovarian Fibroma
- Adnexal / ovarian torsion[1]
Ossifying- Fibroma
- Pathological fracture(s)
- Limb bowing
Prognosis
Oral Fibromas
Oral fibromas are benign tumors. Recurrence of oral fibromas is possible, however, if the offending irritant persists.
Ovarian Fibromas
Ovarian fibromas are almost always benign.
Ossifying Fibroma
Ossifying fibromas tend to regress over time. For locally aggressive lesions, surgical resection is often curative although recurrence has been reported.
Pleural Fibroma
- The majority of pleural fibromas tend to be benign and slow growing. Approximately 78% to 88% of SFT's are benign and 12% to 22% are malignant. In approximately 10 to 25 percent of cases recurrence of the tumor can occur. Late relapse, even for benign tumors, is common.
- Approximately 63% of patients with malignant pleural fibromas will have a recurrence of their tumor, of which more than half will succumb to disease progression within 2 years.
- Among tumors classified as malignant, approximately 10 to 40 percent of those destined to metastasize will do so after five years, and they may recur up to 20 years after initial presentation . Prolonged survival after pleural fibroma recurrence is possible, particularly for those who are amenable to re-resection. Patients with multiple synchronous metastases that are not amenable to surgical intervention, usually have a poor prognosis.
- Recurrence in pleural fibromas may be due to following causes:\
- Incomplete resection
- Tumor seeding within the pleura, peritoneum or meninges, or distant hematogenous spread.
- The most common sites of distant metastasis in SFT at all sites are lung, liver, bone, and brain
Chondromyxoid-Fibroma
Chondromyxoid-fibroma are benign lesions and malignant degeneration is rare. Chondromyxoid-fibromas have a high recurrence rate of approximately 25%.
Cemento-ossifying Fibroma
Recurrence following complete excision of cemento-ossifying fibroma is generally considered to be uncommon. However, in some series, it has been reported to be approximately 16%.
Desmoplastic Fibroma
Desmoplastic fibromas are benign and locally aggressive tumors. Desmoplastic fibroma is a rare benign intraosseous tumor neoplasm. It is usually a localized lesion with propensity for cortical bone perforation and recurrence. They are considered to be a bony counterpart of soft tissue desmoid tumours and are histologically identical. [2]
Sclerotic Fibroma
Sclerotic fibroma is an uncommon benign fibrous neoplasm and may be solitary or multifocal.
Uterine Fibromas
About 1 out of 1000 lesions are or become malignant, typically as a leiomyosarcoma on histology. A sign that a lesion may be malignant is growth after menopause. There are a number of rare conditions in which fibroids metastasize. They still grow in a benign fashion, but can be dangerous depending on their location.
Peripheral odontogenic fibroma
Recurrence is rare
Giant cell fibroma
Giant cell fibroma is a benign non-neoplastic lesion. Recurrence is rare.
References
- ↑ "Ovarian fibroma [Dr Ahmed Abd Rabou and Radswiki]".
- ↑ Cheng, A.; Ji, S.; Pogrel, M.A. (2012). "Poster 55: A Natural History of Desmoplastic Fibroma: Over 20 Years of Experience". Journal of Oral and Maxillofacial Surgery. 70 (9): e74. doi:10.1016/j.joms.2012.06.111. ISSN 0278-2391.