Beriberi overview: Difference between revisions
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Revision as of 04:56, 15 March 2016
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Beriberi Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Beriberi overview On the Web |
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American Roentgen Ray Society Images of Beriberi overview |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Beriberi is a dietary-deficiency disease caused by a lack of thiamine in the diet. Thiamine, initially named "the anti-beriberi factor" in 1926 was the first B vitamin to be identified and is therefore referred to as vitamin B1. Thiamine is soluble in water and partly soluble in alcohol. It consists of a pyrimidine and a thiazole moiety, both of which are essential for its activity. Thiamine functions in the decarboxylation of α-ketoacids, such as pyruvate α-ketoglutarate, and branched-chain amino acids and thus is a source of energy generation. In addition, thiamine pyrophosphate acts as a coenzyme for a transketolase reaction that mediates the conversion of hexose and pentose phosphates.