Mumps medical therapy: Difference between revisions
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==Overview== | |||
No antiviral agent currently exists and therefore supportive care is indicated for patients with mumps. Supportive care includes prescribing [[analgesics]], application of warm or cold packs to swollen areas, warm salt water gargles, and fluid intake. Patients should avoid acidic foods or juices. | |||
==Medical Therapy== | ==Medical Therapy== | ||
There is no specific treatment for mumps. Symptoms may be relieved by the application of intermittent ice or heat to the affected neck area and by [[Acetaminophen]]/Paracetamol (Tylenol) for pain relief. [[Aspirin]] use is discouraged in young children because of studies showing an increased risk of [[Reye's syndrome]]. Warm salt water gargles, soft foods, and extra fluids may also help relieve symptoms. | There is no specific treatment for mumps. Symptoms may be relieved by the application of intermittent ice or heat to the affected neck area and by [[Acetaminophen]]/Paracetamol (Tylenol) for pain relief. [[Aspirin]] use is discouraged in young children because of studies showing an increased risk of [[Reye's syndrome]]. Warm salt water gargles, soft foods, and extra fluids may also help relieve symptoms. Patients are advised to avoid fruit juice or any acidic foods, since these stimulate the salivary glands, which can be painful. | ||
Patients are advised to avoid fruit juice or any acidic foods, since these stimulate the salivary glands, which can be painful. | |||
===Research Treatments=== | ===Research Treatments=== | ||
*A research group published a 1996 report on a chemical extracted from ''[[Spirulina (dietary supplement)|Spirulina platensis]]'', a species of blue-green algae, which inhibited Mumps virus in a [[viral plaque|viral plaque assay]].<ref>{{cite journal | author=Hayashi T, Hayashi K, Maeda M, Kojima I | title=Calcium spirulan, an inhibitor of enveloped virus replication, from a blue-green alga Spirulina platensis | journal=J Nat Prod | year=1996 | pages=83-7 | volume=59 | issue=1 | id={{PMID|8984158}} }}</ref> | *A research group published a 1996 report on a chemical extracted from ''[[Spirulina (dietary supplement)|Spirulina platensis]]'', a species of blue-green algae, which inhibited Mumps virus in a [[viral plaque|viral plaque assay]].<ref>{{cite journal | author=Hayashi T, Hayashi K, Maeda M, Kojima I | title=Calcium spirulan, an inhibitor of enveloped virus replication, from a blue-green alga Spirulina platensis | journal=J Nat Prod | year=1996 | pages=83-7 | volume=59 | issue=1 | id={{PMID|8984158}} }}</ref> | ||
*A University of Tokyo group reported in 1992 that research compound ''TJ13025'' ((6'R)-6'-C-methylneplanocin A) had an antiviral effect on four Mumps virus strains cultured in [[Vero cell]]s.(see [http://www.pubmedcentral.gov/pagerender.fcgi?artid=188453&pageindex=3#page|PMID 16526604, tables 1 and 2]) Additional research improved the synthesis of a particular isomer, RMNPA, of TJ13025 from the racemic product.<ref name=Shuto_1997>{{cite journal | author=Shuto S, Obara T, Yaginuma S, Matsuda A | title=New neplanocin analogues. IX. A practical preparation of (6'R)-6'-C-methylneplanocin A (RMNPA), a potent antiviral eileen, and the determination of its 6'-configuration. Diastereoselective deamination by adenosine deaminase | journal=Chem Pharm Bull (Tokyo) | year=1997 | pages=138-42 | volume=45 | issue1 | id={{PMID|9023976}} }}</ref><ref name=Shuto_2002>{{cite journal | author=Shuto S, Minakawa N, Niizuma S, Kim HS, Wataya Y, Matsuda A | title=New neplanocin analogues. 12. Alternative synthesis and antimalarial effect of (6'R)-6'-C-methylneplanocin A, a potent AdoHcy hydrolase inhibitor | journal=J Med Chem | year=2002 | pages=748-51 | volume=45 | issue=3 | id={{PMID|11806727}} }}</ref> | *A University of Tokyo group reported in 1992 that research compound ''TJ13025'' ((6'R)-6'-C-methylneplanocin A) had an antiviral effect on four Mumps virus strains cultured in [[Vero cell]]s.(see [http://www.pubmedcentral.gov/pagerender.fcgi?artid=188453&pageindex=3#page|PMID 16526604, tables 1 and 2]) Additional research improved the synthesis of a particular isomer, RMNPA, of TJ13025 from the racemic product.<ref name=Shuto_1997>{{cite journal | author=Shuto S, Obara T, Yaginuma S, Matsuda A | title=New neplanocin analogues. IX. A practical preparation of (6'R)-6'-C-methylneplanocin A (RMNPA), a potent antiviral eileen, and the determination of its 6'-configuration. Diastereoselective deamination by adenosine deaminase | journal=Chem Pharm Bull (Tokyo) | year=1997 | pages=138-42 | volume=45 | issue1 | id={{PMID|9023976}} }}</ref><ref name=Shuto_2002>{{cite journal | author=Shuto S, Minakawa N, Niizuma S, Kim HS, Wataya Y, Matsuda A | title=New neplanocin analogues. 12. Alternative synthesis and antimalarial effect of (6'R)-6'-C-methylneplanocin A, a potent AdoHcy hydrolase inhibitor | journal=J Med Chem | year=2002 | pages=748-51 | volume=45 | issue=3 | id={{PMID|11806727}} }}</ref> | ||
*A 2005 publication in a Russian journal reports that Myramistin has antiviral activity against Mumps virus in Vero cells culture.<ref>{{cite journal | author=Agafonov AP, Ignat'ev GM, Svistov VV, Smirnov IV, Krivoshein IuS | title=[In vitro study of antiviral activity of Myramistin against measles and mumps viruses] | journal=Antibiot Khimioter | year=2005 | pages=17-9 | volume=50 | issue=5-6 | id={{PMID|16526604}} }}</ref> | *A 2005 publication in a Russian journal reports that Myramistin has antiviral activity against Mumps virus in Vero cells culture.<ref>{{cite journal | author=Agafonov AP, Ignat'ev GM, Svistov VV, Smirnov IV, Krivoshein IuS | title=[In vitro study of antiviral activity of Myramistin against measles and mumps viruses] | journal=Antibiot Khimioter | year=2005 | pages=17-9 | volume=50 | issue=5-6 | id={{PMID|16526604}} }}</ref> | ||
Revision as of 15:01, 15 March 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Nate Michalak, B.A.
Overview
No antiviral agent currently exists and therefore supportive care is indicated for patients with mumps. Supportive care includes prescribing analgesics, application of warm or cold packs to swollen areas, warm salt water gargles, and fluid intake. Patients should avoid acidic foods or juices.
Medical Therapy
There is no specific treatment for mumps. Symptoms may be relieved by the application of intermittent ice or heat to the affected neck area and by Acetaminophen/Paracetamol (Tylenol) for pain relief. Aspirin use is discouraged in young children because of studies showing an increased risk of Reye's syndrome. Warm salt water gargles, soft foods, and extra fluids may also help relieve symptoms. Patients are advised to avoid fruit juice or any acidic foods, since these stimulate the salivary glands, which can be painful.
Research Treatments
- A research group published a 1996 report on a chemical extracted from Spirulina platensis, a species of blue-green algae, which inhibited Mumps virus in a viral plaque assay.[1]
- A University of Tokyo group reported in 1992 that research compound TJ13025 ((6'R)-6'-C-methylneplanocin A) had an antiviral effect on four Mumps virus strains cultured in Vero cells.(see 16526604, tables 1 and 2) Additional research improved the synthesis of a particular isomer, RMNPA, of TJ13025 from the racemic product.[2][3]
- A 2005 publication in a Russian journal reports that Myramistin has antiviral activity against Mumps virus in Vero cells culture.[4]
References
- ↑ Hayashi T, Hayashi K, Maeda M, Kojima I (1996). "Calcium spirulan, an inhibitor of enveloped virus replication, from a blue-green alga Spirulina platensis". J Nat Prod. 59 (1): 83–7. PMID 8984158.
- ↑ Shuto S, Obara T, Yaginuma S, Matsuda A (1997). "New neplanocin analogues. IX. A practical preparation of (6'R)-6'-C-methylneplanocin A (RMNPA), a potent antiviral eileen, and the determination of its 6'-configuration. Diastereoselective deamination by adenosine deaminase". Chem Pharm Bull (Tokyo). 45: 138–42. PMID 9023976. Text " issue1 " ignored (help)
- ↑ Shuto S, Minakawa N, Niizuma S, Kim HS, Wataya Y, Matsuda A (2002). "New neplanocin analogues. 12. Alternative synthesis and antimalarial effect of (6'R)-6'-C-methylneplanocin A, a potent AdoHcy hydrolase inhibitor". J Med Chem. 45 (3): 748–51. PMID 11806727.
- ↑ Agafonov AP, Ignat'ev GM, Svistov VV, Smirnov IV, Krivoshein IuS (2005). "[In vitro study of antiviral activity of Myramistin against measles and mumps viruses]". Antibiot Khimioter. 50 (5–6): 17–9. PMID 16526604.