Mumps pathophysiology: Difference between revisions
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*Humans are the only natural host for mumps virus (MuV). | *Humans are the only natural host for mumps virus (MuV). | ||
*MuV is transmitted through respiratory droplets (saliva or mucus), direct contact, or contact with surfaces carrying MuV. | *MuV is transmitted through respiratory droplets (saliva or mucus), direct contact, or contact with surfaces carrying MuV. | ||
*Mumps is contagious several days prior and up to 5 days after onset of [[ | *Mumps is contagious several days prior and up to 5 days after onset of [[parotitis]]. | ||
===Pathogenesis=== | ===Pathogenesis=== | ||
*MuV enters the body through inhalation or oral contact and infects the upper respiratory tract epithelium.<ref name="pmid25229387">{{cite journal| author=Rubin S, Eckhaus M, Rennick LJ, Bamford CG, Duprex WP| title=Molecular biology, pathogenesis and pathology of mumps virus. | journal=J Pathol | year= 2015 | volume= 235 | issue= 2 | pages= 242-52 | pmid=25229387 | doi=10.1002/path.4445 | pmc=PMC4268314 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25229387 }} </ref> | *MuV enters the body through inhalation or oral contact and infects the [[upper respiratory tract]] [[epithelium]].<ref name="pmid25229387">{{cite journal| author=Rubin S, Eckhaus M, Rennick LJ, Bamford CG, Duprex WP| title=Molecular biology, pathogenesis and pathology of mumps virus. | journal=J Pathol | year= 2015 | volume= 235 | issue= 2 | pages= 242-52 | pmid=25229387 | doi=10.1002/path.4445 | pmc=PMC4268314 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25229387 }} </ref> | ||
*MuV is able to attach to extracellular sialic acid via the | *MuV is able to attach to extracellular sialic acid via the hemagglutinin-neuraminidase (HN) [[glycoprotein]]. | ||
*HN and the fusion (F) glycoprotein mediate cell membrane fusion, allowing viral material to enter respiratory epithelial cells. | *HN and the fusion (F) glycoprotein mediate cell membrane fusion, allowing viral material to enter respiratory [[Epithelium|epithelial cells]]. | ||
*HN and F, in conjunction with matrix (M) protein, are also involved in localizing viral material after replication and inducing virion budding. | *HN and F, in conjunction with matrix (M) protein, are also involved in localizing viral material after replication and inducing [[virion]] budding. | ||
*MuV is able to inhibit an immune response to infection with the following virulence factors: | *MuV is able to inhibit an immune response to infection with the following [[Virulence factor|virulence factors]]: | ||
:*Small hydrophobic (SH) protein is presumed to block TNFα-mediated apoptosis.<ref name="pmid11287556">{{cite journal| author=He B, Lin GY, Durbin JE, Durbin RK, Lamb RA| title=The SH integral membrane protein of the paramyxovirus simian virus 5 is required to block apoptosis in MDBK cells. | journal=J Virol | year= 2001 | volume= 75 | issue= 9 | pages= 4068-79 | pmid=11287556 | doi=10.1128/JVI.75.9.4068-4079.2001 | pmc=PMC114152 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11287556 }} </ref> | :*Small hydrophobic (SH) protein is presumed to block [[Tumor necrosis factor-alpha|TNFα-mediated apoptosis]].<ref name="pmid11287556">{{cite journal| author=He B, Lin GY, Durbin JE, Durbin RK, Lamb RA| title=The SH integral membrane protein of the paramyxovirus simian virus 5 is required to block apoptosis in MDBK cells. | journal=J Virol | year= 2001 | volume= 75 | issue= 9 | pages= 4068-79 | pmid=11287556 | doi=10.1128/JVI.75.9.4068-4079.2001 | pmc=PMC114152 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11287556 }} </ref> | ||
:*Non-structural proteins NS1 and NS2 (V proteins) inhibit IFN production and signaling.<ref name="pmid15563593">{{cite journal| author=Andrejeva J, Childs KS, Young DF, Carlos TS, Stock N, Goodbourn S et al.| title=The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter. | journal=Proc Natl Acad Sci U S A | year= 2004 | volume= 101 | issue= 49 | pages= 17264-9 | pmid=15563593 | doi=10.1073/pnas.0407639101 | pmc=PMC535396 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15563593 }} </ref> | :*Non-structural proteins NS1 and NS2 (V proteins) inhibit [[IFN]] production and signaling.<ref name="pmid15563593">{{cite journal| author=Andrejeva J, Childs KS, Young DF, Carlos TS, Stock N, Goodbourn S et al.| title=The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter. | journal=Proc Natl Acad Sci U S A | year= 2004 | volume= 101 | issue= 49 | pages= 17264-9 | pmid=15563593 | doi=10.1073/pnas.0407639101 | pmc=PMC535396 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15563593 }} </ref> | ||
*MuV disseminates through the lymphatic system to cause systemic infection. | *MuV disseminates through the [[lymphatic system]] to cause systemic infection. | ||
*Replication in the parotid gland (or other salivary gland) causes mononuclear cell infiltration, hemorrhage, edema, and necrosis. | *Replication in the [[parotid gland]] (or other salivary gland) causes [[mononuclear cell]] infiltration, [[hemorrhage]], [[edema]], and [[necrosis]]. | ||
====Virulence Factors==== | ====Virulence Factors==== | ||
Revision as of 14:59, 17 March 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Lakshmi Gopalakrishnan, M.B.B.S. [2]; Nate Michalak, B.A.
Overview
Mumps is spread by droplets of saliva or mucus from the mouth, nose, or throat of an infected person, usually when the person coughs or sneezes. Most mumps transmission occurs before the enlargement of the salivary glands and within the 5 days after the swelling begins. Therefore, the CDC recommends isolating mumps patients for 5 days after their glands begin to swell.
Pathophysiology
Transmission
- Humans are the only natural host for mumps virus (MuV).
- MuV is transmitted through respiratory droplets (saliva or mucus), direct contact, or contact with surfaces carrying MuV.
- Mumps is contagious several days prior and up to 5 days after onset of parotitis.
Pathogenesis
- MuV enters the body through inhalation or oral contact and infects the upper respiratory tract epithelium.[1]
- MuV is able to attach to extracellular sialic acid via the hemagglutinin-neuraminidase (HN) glycoprotein.
- HN and the fusion (F) glycoprotein mediate cell membrane fusion, allowing viral material to enter respiratory epithelial cells.
- HN and F, in conjunction with matrix (M) protein, are also involved in localizing viral material after replication and inducing virion budding.
- MuV is able to inhibit an immune response to infection with the following virulence factors:
- Small hydrophobic (SH) protein is presumed to block TNFα-mediated apoptosis.[2]
- Non-structural proteins NS1 and NS2 (V proteins) inhibit IFN production and signaling.[3]
- MuV disseminates through the lymphatic system to cause systemic infection.
- Replication in the parotid gland (or other salivary gland) causes mononuclear cell infiltration, hemorrhage, edema, and necrosis.
Virulence Factors
- Small hydrophobic (SH) protein: blocks TNFα-mediated apoptosis
- Non-structural proteins NS1 and NS2 (V proteins): inhibit IFN production and signaling
- Haemagglutinin-neuraminidase (HN) glycoprotein: binds with extracellular host cell sialic acid
Resources
References
- ↑ Rubin S, Eckhaus M, Rennick LJ, Bamford CG, Duprex WP (2015). "Molecular biology, pathogenesis and pathology of mumps virus". J Pathol. 235 (2): 242–52. doi:10.1002/path.4445. PMC 4268314. PMID 25229387.
- ↑ He B, Lin GY, Durbin JE, Durbin RK, Lamb RA (2001). "The SH integral membrane protein of the paramyxovirus simian virus 5 is required to block apoptosis in MDBK cells". J Virol. 75 (9): 4068–79. doi:10.1128/JVI.75.9.4068-4079.2001. PMC 114152. PMID 11287556.
- ↑ Andrejeva J, Childs KS, Young DF, Carlos TS, Stock N, Goodbourn S; et al. (2004). "The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter". Proc Natl Acad Sci U S A. 101 (49): 17264–9. doi:10.1073/pnas.0407639101. PMC 535396. PMID 15563593.