Creutzfeldt-Jakob disease diagnostic criteria: Difference between revisions
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==Diagnostic Criteria== | ==Diagnostic Criteria== | ||
==Criteria for a ''Probable'' Diagnosis== | |||
Diagnosis of Creutzfeldt Jakob disease is '''probable''' if following criteria are fulfilled: | Diagnosis of Creutzfeldt Jakob disease is '''probable''' if following criteria are fulfilled: | ||
* Rapidly progressive dementia plus at least any 2 of the following features | *Rapidly progressive dementia plus at least any 2 of the following features | ||
:* Myoclonus | :* Myoclonus | ||
:* Visual or cerebellar signs | :* Visual or cerebellar signs | ||
:* Pyramidal and/or extrapyramidal signs | :* Pyramidal and/or extrapyramidal signs | ||
:* [[Akinetic mutism]] | :* [[Akinetic mutism]] | ||
PLUS<br> | '''PLUS'''<br> | ||
* Positive result on one of the following laboratory tests: | * Positive result on one of the following laboratory tests: | ||
:* Typical [[EEG]] (periodic sharp wave complexes) during an illness of any duration and/or | :* Typical [[EEG]] (periodic sharp wave complexes) during an illness of any duration and/or | ||
:* A positive 14-3-3 [[cerebrospinal fluid]] (CSF) assay in patients with a disease duration of less than 2 years and/or | :* A positive 14-3-3 [[cerebrospinal fluid]] (CSF) assay in patients with a disease duration of less than 2 years and/or | ||
:* Magnetic resonance imaging (MRI): high signal abnormalities in [[caudate nucleus]] and/or [[putamen]] on diffusion-weighted imaging (DWI) or fluid attenuated inversion recovery (FLAIR). | :* Magnetic resonance imaging (MRI): high signal abnormalities in [[caudate nucleus]] and/or [[putamen]] on diffusion-weighted imaging (DWI) or fluid attenuated inversion recovery (FLAIR). | ||
PLUS<br> | '''PLUS'''<br> | ||
* No alternative diagnosis is suspected on routine investigation.<ref name="www.cdc.gov">{{Cite web | last = | first = | title = http://www.cdc.gov/ncidod/dvrd/cjd/diagnostic_criteria.html | url = http://www.cdc.gov/ncidod/dvrd/cjd/diagnostic_criteria.html | publisher = | date = | accessdate = 17 February 2014 }}</ref> | * No alternative diagnosis is suspected on routine investigation.<ref name="www.cdc.gov">{{Cite web | last = | first = | title = http://www.cdc.gov/ncidod/dvrd/cjd/diagnostic_criteria.html | url = http://www.cdc.gov/ncidod/dvrd/cjd/diagnostic_criteria.html | publisher = | date = | accessdate = 17 February 2014 }}</ref> | ||
==Criteria for a ''Possible'' Diagnosis== | |||
Diagnosis of Creutzfeldt Jakob disease is '''possible''' if following criteria are fulfilled: | Diagnosis of Creutzfeldt Jakob disease is '''possible''' if following criteria are fulfilled: | ||
* Rapidly progressive dementia plus at least any 2 of the following features | * Rapidly progressive dementia plus at least any 2 of the following features | ||
| Line 27: | Line 27: | ||
:* Pyramidal and/or extrapyramidal signs | :* Pyramidal and/or extrapyramidal signs | ||
:* [[Akinetic mutism]] | :* [[Akinetic mutism]] | ||
PLUS<br> | '''PLUS'''<br> | ||
* Absence of a positive result for any of the three laboratory tests that would classify a case as probable (see above).<br> | * Absence of a positive result for any of the three laboratory tests that would classify a case as probable (see above).<br> | ||
PLUS<br> | '''PLUS'''<br> | ||
* Duration of illness is less than two years.<br> | * Duration of illness is less than two years.<br> | ||
PLUS<br> | '''PLUS'''<br> | ||
* No alternative diagnosis is suspected on routine investigation.<ref name="www.cdc.gov">{{Cite web | last = | first = | title = http://www.cdc.gov/ncidod/dvrd/cjd/diagnostic_criteria.html | url = http://www.cdc.gov/ncidod/dvrd/cjd/diagnostic_criteria.html | publisher = | date = | accessdate = 17 February 2014 }}</ref> | * No alternative diagnosis is suspected on routine investigation.<ref name="www.cdc.gov">{{Cite web | last = | first = | title = http://www.cdc.gov/ncidod/dvrd/cjd/diagnostic_criteria.html | url = http://www.cdc.gov/ncidod/dvrd/cjd/diagnostic_criteria.html | publisher = | date = | accessdate = 17 February 2014 }}</ref> | ||
Revision as of 20:05, 22 March 2016
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Creutzfeldt-Jakob disease Microchapters |
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Differentiating Creutzfeldt-Jakob disease from other Diseases |
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Creutzfeldt-Jakob disease diagnostic criteria On the Web |
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American Roentgen Ray Society Images of Creutzfeldt-Jakob disease diagnostic criteria |
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Risk calculators and risk factors for Creutzfeldt-Jakob disease diagnostic criteria |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
The diagnosis of Creutzfeldt Jakob disease depends on a combination of positive findings from physical examination and laboratory testing. Based on the findings, the diagnosis of Creutzfeldt Jakob disease may be either probable or possible. There are no definitive criteria for the diagnosis of Creutzfeldt Jakob disease.
Diagnostic Criteria
Criteria for a Probable Diagnosis
Diagnosis of Creutzfeldt Jakob disease is probable if following criteria are fulfilled:
- Rapidly progressive dementia plus at least any 2 of the following features
- Myoclonus
- Visual or cerebellar signs
- Pyramidal and/or extrapyramidal signs
- Akinetic mutism
PLUS
- Positive result on one of the following laboratory tests:
- Typical EEG (periodic sharp wave complexes) during an illness of any duration and/or
- A positive 14-3-3 cerebrospinal fluid (CSF) assay in patients with a disease duration of less than 2 years and/or
- Magnetic resonance imaging (MRI): high signal abnormalities in caudate nucleus and/or putamen on diffusion-weighted imaging (DWI) or fluid attenuated inversion recovery (FLAIR).
PLUS
- No alternative diagnosis is suspected on routine investigation.[1]
Criteria for a Possible Diagnosis
Diagnosis of Creutzfeldt Jakob disease is possible if following criteria are fulfilled:
- Rapidly progressive dementia plus at least any 2 of the following features
- Myoclonus
- Visual or cerebellar signs
- Pyramidal and/or extrapyramidal signs
- Akinetic mutism
PLUS
- Absence of a positive result for any of the three laboratory tests that would classify a case as probable (see above).
PLUS
- Duration of illness is less than two years.
PLUS
- No alternative diagnosis is suspected on routine investigation.[1]
References
- ↑ 1.0 1.1 "http://www.cdc.gov/ncidod/dvrd/cjd/diagnostic_criteria.html". Retrieved 17 February 2014. External link in
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