Crohn's disease overview: Difference between revisions
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==Overview== | ==Overview== | ||
''[[Crohn's disease]]'' is a [[Chronic (medical)|chronic]], episodic, [[Inflammation|inflammatory]] [[inflammatory bowel disease|bowel disease]] (IBD) that affects the entire wall of the [[bowel]] or [[intestine]]s. Crohn's disease can affect any part of the [[gastrointestinal tract]] from [[mouth]] to [[anus]]; as a result, the symptoms of Crohn's disease vary among afflicted individuals. The disease is characterized by areas of inflammation with areas of normal lining between in a symptom known as skip [[lesions]]. The main gastrointestinal symptoms are [[abdominal pain]], [[diarrhea]] (which may be bloody or the blood may not be seen by the naked eye), [[constipation]], [[vomiting]], [[weight loss]] or [[weight gain]]. Crohn's disease can also cause complications outside of the gastrointestinal tract such as [[Rash|skin rashes]], [[arthritis]], and [[Uveitis|inflammation of the eye]].<ref name=Hanauer>{{cite journal | last = Hanauer | first = Stephen B. | year = 1996 | month = March | title = Inflammatory bowel disease | journal = New England Journal of Medicine | volume = 334 | issue = 13 | pages = 841-848 | id = PMID 8596552 | url = http://content.nejm.org/cgi/content/extract/334/13/841 | accessdate = 2006-11-10}}</ref> | ''[[Crohn's disease]]'' is a [[Chronic (medical)|chronic]], episodic, [[Inflammation|inflammatory]] [[inflammatory bowel disease|bowel disease]] (IBD) that affects the entire wall of the [[bowel]] or [[intestine]]s. Crohn's disease can affect any part of the [[gastrointestinal tract]] from [[mouth]] to [[anus]]; as a result, the symptoms of Crohn's disease vary among afflicted individuals. The disease is characterized by areas of inflammation with areas of normal lining between in a symptom known as skip [[lesions]]. The main gastrointestinal symptoms are [[abdominal pain]], [[diarrhea]] (which may be bloody or the blood may not be seen by the naked eye), [[constipation]], [[vomiting]], [[weight loss]] or [[weight gain]]. Crohn's disease can also cause complications outside of the gastrointestinal tract such as [[Rash|skin rashes]], [[arthritis]], and [[Uveitis|inflammation of the eye]].<ref name=Hanauer>{{cite journal | last = Hanauer | first = Stephen B. | year = 1996 | month = March | title = Inflammatory bowel disease | journal = New England Journal of Medicine | volume = 334 | issue = 13 | pages = 841-848 | id = PMID 8596552 | url = http://content.nejm.org/cgi/content/extract/334/13/841 | accessdate = 2006-11-10}}</ref> | ||
==Historical Perspective== | |||
==Classification== | |||
==Pathophysiology== | |||
==Causes== | ==Causes== | ||
Several theories exist about what causes Crohn’s disease, but none have been proven. The human [[immune system]] is made from cells and different proteins that protect people from infection. The most popular theory is that the body’s immune system reacts abnormally in people with Crohn’s disease, mistaking[[bacteria]], foods, and other substances for being foreign. The immune system’s response is to attack these “invaders.” During this process, white blood cells accumulate in the lining of the intestines, producing chronic [[inflammation]], which leads to ulcerations and bowel injury. | Several theories exist about what causes Crohn’s disease, but none have been proven. The human [[immune system]] is made from cells and different proteins that protect people from infection. The most popular theory is that the body’s immune system reacts abnormally in people with Crohn’s disease, mistaking[[bacteria]], foods, and other substances for being foreign. The immune system’s response is to attack these “invaders.” During this process, white blood cells accumulate in the lining of the intestines, producing chronic [[inflammation]], which leads to ulcerations and bowel injury. | ||
==Differentiating Crohn's Disease from Other Diseases== | |||
==Epidemiology and Demographics== | |||
==Risk Factors== | |||
==Natural History, Complications and Prognosis== | |||
==Diagnosis== | ==Diagnosis== | ||
===History and Symptoms=== | |||
===Physical Examination=== | |||
===Laboratory Findings=== | |||
===Other Diagnostic Studies=== | ===Other Diagnostic Studies=== | ||
The diagnosis of Crohn's disease can sometimes be challenging, and a number of tests are often required to assist the physician in making the diagnosis. Sometimes even with all the tests the Crohn's does not show itself. A colonoscopy has about a 70% chance of showing the disease and the rest of the tests go down in percentage. Disease in the small bowel can not be seen through some of the regular tests; for example, a [[colonoscopy]] can't get there. | The diagnosis of Crohn's disease can sometimes be challenging, and a number of tests are often required to assist the physician in making the diagnosis. Sometimes even with all the tests the Crohn's does not show itself. A colonoscopy has about a 70% chance of showing the disease and the rest of the tests go down in percentage. Disease in the small bowel can not be seen through some of the regular tests; for example, a [[colonoscopy]] can't get there. | ||
===Electrocardiogram=== | |||
===Chest X Ray=== | |||
===CT Scan=== | |||
===Echocardiography or Ultrasound=== | |||
===Other Imaging Findings=== | |||
==Treatment== | ==Treatment== | ||
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Treatment may include drugs, nutrition supplements, [[surgery]], or a combination of these options. The goals of treatment are to control inflammation, correct nutritional deficiencies, and relieve symptoms like[[abdominal pain]], [[diarrhea]], and [[rectal bleeding]]. At this time, treatment can help control the disease by lowering the number of times a person experiences a recurrence, but there is no cure. Treatment for Crohn’s disease depends on the location and severity of disease, [[complication]]s, and the person’s response to previous medical treatments when treated for recurring symptoms. Some people have long periods of remission, sometimes years, when they are free of symptoms. However, the disease usually recurs at various times over a person’s lifetime. This changing pattern of the disease means one cannot always tell when a treatment has helped. Predicting when a remission may occur or when symptoms will return is not possible. | Treatment may include drugs, nutrition supplements, [[surgery]], or a combination of these options. The goals of treatment are to control inflammation, correct nutritional deficiencies, and relieve symptoms like[[abdominal pain]], [[diarrhea]], and [[rectal bleeding]]. At this time, treatment can help control the disease by lowering the number of times a person experiences a recurrence, but there is no cure. Treatment for Crohn’s disease depends on the location and severity of disease, [[complication]]s, and the person’s response to previous medical treatments when treated for recurring symptoms. Some people have long periods of remission, sometimes years, when they are free of symptoms. However, the disease usually recurs at various times over a person’s lifetime. This changing pattern of the disease means one cannot always tell when a treatment has helped. Predicting when a remission may occur or when symptoms will return is not possible. | ||
===Surgery=== | |||
===Prevention=== | |||
[[Category:Disease]] | [[Category:Disease]] | ||
Revision as of 18:27, 13 June 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Crohn's disease is a chronic, episodic, inflammatory bowel disease (IBD) that affects the entire wall of the bowel or intestines. Crohn's disease can affect any part of the gastrointestinal tract from mouth to anus; as a result, the symptoms of Crohn's disease vary among afflicted individuals. The disease is characterized by areas of inflammation with areas of normal lining between in a symptom known as skip lesions. The main gastrointestinal symptoms are abdominal pain, diarrhea (which may be bloody or the blood may not be seen by the naked eye), constipation, vomiting, weight loss or weight gain. Crohn's disease can also cause complications outside of the gastrointestinal tract such as skin rashes, arthritis, and inflammation of the eye.[1]
Historical Perspective
Classification
Pathophysiology
Causes
Several theories exist about what causes Crohn’s disease, but none have been proven. The human immune system is made from cells and different proteins that protect people from infection. The most popular theory is that the body’s immune system reacts abnormally in people with Crohn’s disease, mistakingbacteria, foods, and other substances for being foreign. The immune system’s response is to attack these “invaders.” During this process, white blood cells accumulate in the lining of the intestines, producing chronic inflammation, which leads to ulcerations and bowel injury.
Differentiating Crohn's Disease from Other Diseases
Epidemiology and Demographics
Risk Factors
Natural History, Complications and Prognosis
Diagnosis
History and Symptoms
Physical Examination
Laboratory Findings
Other Diagnostic Studies
The diagnosis of Crohn's disease can sometimes be challenging, and a number of tests are often required to assist the physician in making the diagnosis. Sometimes even with all the tests the Crohn's does not show itself. A colonoscopy has about a 70% chance of showing the disease and the rest of the tests go down in percentage. Disease in the small bowel can not be seen through some of the regular tests; for example, a colonoscopy can't get there.
Electrocardiogram
Chest X Ray
CT Scan
Echocardiography or Ultrasound
Other Imaging Findings
Treatment
Medical Therapy
Treatment may include drugs, nutrition supplements, surgery, or a combination of these options. The goals of treatment are to control inflammation, correct nutritional deficiencies, and relieve symptoms likeabdominal pain, diarrhea, and rectal bleeding. At this time, treatment can help control the disease by lowering the number of times a person experiences a recurrence, but there is no cure. Treatment for Crohn’s disease depends on the location and severity of disease, complications, and the person’s response to previous medical treatments when treated for recurring symptoms. Some people have long periods of remission, sometimes years, when they are free of symptoms. However, the disease usually recurs at various times over a person’s lifetime. This changing pattern of the disease means one cannot always tell when a treatment has helped. Predicting when a remission may occur or when symptoms will return is not possible.
Surgery
Prevention
References
- ↑ Hanauer, Stephen B. (1996). "Inflammatory bowel disease". New England Journal of Medicine. 334 (13): 841–848. PMID 8596552. Retrieved 2006-11-10. Unknown parameter
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