Urethritis pathophysiology: Difference between revisions
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::Pili, | ::Pili, | ||
::The ability to attach to urethral epithelial cells, | ::The ability to attach to urethral epithelial cells, | ||
::Production of extracellular proteases that cleave IgA | ::Production of extracellular proteases that cleave IgA | ||
*Following attachment to host cell which is mediated by pili, gonococci become engulfed in a process known as parasite-directed endocytosis. This organism will survive inside the vacuoles and replicate<ref name="pmid9916098">{{cite journal |vauthors=Scheuerpflug I, Rudel T, Ryll R, Pandit J, Meyer TF |title=Roles of PilC and PilE proteins in pilus-mediated adherence of Neisseria gonorrhoeae and Neisseria meningitidis to human erythrocytes and endothelial and epithelial cells |journal=Infect. Immun. |volume=67 |issue=2 |pages=834–43 |year=1999 |pmid=9916098 |pmc=96394 |doi= |url=}}</ref>. | *Following attachment to host cell which is mediated by pili, gonococci become engulfed in a process known as parasite-directed endocytosis. This organism will survive inside the vacuoles and replicate<ref name="pmid9916098">{{cite journal |vauthors=Scheuerpflug I, Rudel T, Ryll R, Pandit J, Meyer TF |title=Roles of PilC and PilE proteins in pilus-mediated adherence of Neisseria gonorrhoeae and Neisseria meningitidis to human erythrocytes and endothelial and epithelial cells |journal=Infect. Immun. |volume=67 |issue=2 |pages=834–43 |year=1999 |pmid=9916098 |pmc=96394 |doi= |url=}}</ref>. | ||
==References== | ==References== | ||
Revision as of 20:57, 21 September 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Seyedmahdi Pahlavani, M.D. [2]
Overview
Pathophysiology
Urethritis is divided to gonorrheal and non-gonorrheal.Its Pathophysiology Depends on the etiology.
Gonorrhea
- N. gonorrhoeae is usually transmitted via the genital tract to the human host.
- Gonococcal virulence factors include[1][2][3]:
- Pili,
- The ability to attach to urethral epithelial cells,
- Production of extracellular proteases that cleave IgA
- Following attachment to host cell which is mediated by pili, gonococci become engulfed in a process known as parasite-directed endocytosis. This organism will survive inside the vacuoles and replicate[4].
References
- ↑ Sparling PF (1966). "Genetic transformation of Neisseria gonorrhoeae to streptomycin resistance". J Bacteriol. 92 (5): 1364–71. PMC 276432. PMID 4958881.
- ↑ Swanson J (1973). "Studies on gonococcus infection. IV. Pili: their role in attachment of gonococci to tissue culture cells". J Exp Med. 137 (3): 571–89. PMC 2139381. PMID 4631989.
- ↑ Wolfgang M, Lauer P, Park HS, Brossay L, Hébert J, Koomey M (1998). "PilT mutations lead to simultaneous defects in competence for natural transformation and twitching motility in piliated Neisseria gonorrhoeae". Mol Microbiol. 29 (1): 321–30. PMID 9701824.
- ↑ Scheuerpflug I, Rudel T, Ryll R, Pandit J, Meyer TF (1999). "Roles of PilC and PilE proteins in pilus-mediated adherence of Neisseria gonorrhoeae and Neisseria meningitidis to human erythrocytes and endothelial and epithelial cells". Infect. Immun. 67 (2): 834–43. PMC 96394. PMID 9916098.