Neutropenia pathophysiology

Neutropenia Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Neutropenia from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
History and Symptoms
Physical Examination
Laboratory Findings
Chest X Ray
CT
MRI
Ultrasound
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Neutropenia pathophysiology On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Neutropenia pathophysiology All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Neutropenia pathophysiology
on Neutropenia pathophysiology
Neutropenia pathophysiology in the news
Blogs on Neutropenia pathophysiology
Directions to Hospitals Treating Neutropenia
Risk calculators and risk factors for Neutropenia pathophysiology

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief:

Overview

Please help WikiDoc by adding content here. It's easy! Click here to learn about editing.

Pathophysiology

Neutropenia develops as a result of one of the three following mechanisms:

1) Impaired granulocyte production

- Hematologic malignancy with bone marrow infiltration

- Myelosuppressive chemotherapy or other medications that are toxic to the bone marrow

- Nutritional deficiencies

2) Margination (process where free flowing blood cells exit circulation)

- Splenic sequestration

- Adherence to the vascular endothelium

3) Peripheral destruction

- Autoimmune hemolysis

- Drug-induced hemolysis