Multiple sclerosis differential diagnosis: Difference between revisions
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==Overview== | ==Overview== | ||
The signs and symptoms of MS can be similar to other medical problems, such as [[Devic's disease|neuromyelitis optica]], [[stroke]], [[acute disseminated encephalomyelitis|brain inflammation]], [[infection]]s such as [[Lyme disease]] (which can produce identical MRI lesions and CSF abnormalities<ref>Garcia-Monco JC; Miro Jornet J; Fernandez Villar B; Benach JL; Guerrero Espejo A; Berciano JA. ''[Multiple sclerosis or Lyme disease? a diagnosis problem of exclusion]'' Med Clin (Barc) 1990 May 12;94(18):685-8.PMID 2388492</ref><ref>Hansen K; Cruz M; Link H. ''Oligoclonal Borrelia burgdorferi-specific IgG antibodies in cerebrospinal fluid in Lyme neuroborreliosis.'' J Infect Dis 1990 Jun;161(6):1194-202. PMID 2345300</ref><ref>Schluesener HJ; Martin R; Sticht-Groh V.''Autoimmunity in Lyme disease: molecular cloning of antigens recognized by antibodies in the cerebrospinal fluid.'' Autoimmunity 1989 2(4):323-30. PMID 2491615</ref><ref>Kohler J; Kern U; Kasper J; Rhese-Kupper B; Thoden U. ''Chronic central nervous system involvement in Lyme borreliosis'' Neurology 1988 Jun;38(6):863-7. PMID 3368066</ref>), [[tumor]]s, and other autoimmune problems, such as [[lupus erythematosus|lupus]]. Additional testing may be needed to help distinguish MS from these other problems. | The signs and symptoms of MS can be similar to other medical problems, such as [[Devic's disease|neuromyelitis optica]], [[stroke]], [[acute disseminated encephalomyelitis|brain inflammation]], [[infection]]s such as [[Lyme disease]] (which can produce identical MRI lesions and CSF abnormalities<ref>Garcia-Monco JC; Miro Jornet J; Fernandez Villar B; Benach JL; Guerrero Espejo A; Berciano JA. ''[Multiple sclerosis or Lyme disease? a diagnosis problem of exclusion]'' Med Clin (Barc) 1990 May 12;94(18):685-8.PMID 2388492</ref><ref>Hansen K; Cruz M; Link H. ''Oligoclonal Borrelia burgdorferi-specific IgG antibodies in cerebrospinal fluid in Lyme neuroborreliosis.'' J Infect Dis 1990 Jun;161(6):1194-202. PMID 2345300</ref><ref>Schluesener HJ; Martin R; Sticht-Groh V.''Autoimmunity in Lyme disease: molecular cloning of antigens recognized by antibodies in the cerebrospinal fluid.'' Autoimmunity 1989 2(4):323-30. PMID 2491615</ref><ref>Kohler J; Kern U; Kasper J; Rhese-Kupper B; Thoden U. ''Chronic central nervous system involvement in Lyme borreliosis'' Neurology 1988 Jun;38(6):863-7. PMID 3368066</ref>), [[tumor]]s, and other autoimmune problems, such as [[lupus erythematosus|lupus]]. Additional testing may be needed to help distinguish MS from these other problems. | ||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
*[[Neurosyphilis]]<ref name="pmid24365430">{{cite journal |vauthors=Berger JR, Dean D |title=Neurosyphilis |journal=Handb Clin Neurol |volume=121 |issue= |pages=1461–72 |year=2014 |pmid=24365430 |doi=10.1016/B978-0-7020-4088-7.00098-5 |url=}}</ref> | |||
==References== | ==References== | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
The signs and symptoms of MS can be similar to other medical problems, such as neuromyelitis optica, stroke, brain inflammation, infections such as Lyme disease (which can produce identical MRI lesions and CSF abnormalities[1][2][3][4]), tumors, and other autoimmune problems, such as lupus. Additional testing may be needed to help distinguish MS from these other problems.
Differential Diagnosis
References
- ↑ Garcia-Monco JC; Miro Jornet J; Fernandez Villar B; Benach JL; Guerrero Espejo A; Berciano JA. [Multiple sclerosis or Lyme disease? a diagnosis problem of exclusion] Med Clin (Barc) 1990 May 12;94(18):685-8.PMID 2388492
- ↑ Hansen K; Cruz M; Link H. Oligoclonal Borrelia burgdorferi-specific IgG antibodies in cerebrospinal fluid in Lyme neuroborreliosis. J Infect Dis 1990 Jun;161(6):1194-202. PMID 2345300
- ↑ Schluesener HJ; Martin R; Sticht-Groh V.Autoimmunity in Lyme disease: molecular cloning of antigens recognized by antibodies in the cerebrospinal fluid. Autoimmunity 1989 2(4):323-30. PMID 2491615
- ↑ Kohler J; Kern U; Kasper J; Rhese-Kupper B; Thoden U. Chronic central nervous system involvement in Lyme borreliosis Neurology 1988 Jun;38(6):863-7. PMID 3368066
- ↑ Berger JR, Dean D (2014). "Neurosyphilis". Handb Clin Neurol. 121: 1461–72. doi:10.1016/B978-0-7020-4088-7.00098-5. PMID 24365430.