HIV associated nephropathy laboratory findings: Difference between revisions
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==Overview== | ==Overview== | ||
==Laboratory Findings== | ==Laboratory Findings== | ||
Laboratory findings consistent with the diagnosis of HIV-associated nephropathy include, high-grade proteinuria, elevated serum creatinine levels, hypoalbuniemia, hyperlipidemia | Laboratory findings consistent with the diagnosis of HIV-associated nephropathy include, high-grade proteinuria, elevated serum creatinine levels, hypoalbuniemia, hyperlipidemia, CD4 counts below 200 cells/mm<sup>3</sup>, hyaline casts, leukocytes, oval fat bodies, and microhematuria. Routine laboratory tests that may be ordered to help in identify HIV-associated nephropathy are: | ||
'''Blood Work-up''' | '''Blood Work-up''' | ||
* Complete blood count (CBC) | * Complete blood count (CBC) | ||
* Serum creatinine | * Serum creatinine | ||
* | * Lipid profile | ||
* Albumin | |||
* ELISA | |||
* Dot blot | |||
* Latex agglutination test | |||
'''Supplemental Test''' | |||
* Western blot | |||
* Immunofluorescence | |||
'''Urinalysis''' | |||
* Proteinuria | |||
* Microhematuria | |||
* Leukocytes | |||
* Oval fat bodies | |||
* Hyaline casts | |||
'''Renal Biopsy''' | |||
Renal biopsy is the standard in establishing a diagnosis of HIV-associated nephropathy. Renal biopsy reveals focal segmental glomerulonephritis, significant tubulointerstitial injury and microcystic tubular dilation are characteristically seen. <ref name="pmid2770114">{{cite journal| author=D'Agati V, Suh JI, Carbone L, Cheng JT, Appel G| title=Pathology of HIV-associated nephropathy: a detailed morphologic and comparative study. | journal=Kidney Int | year= 1989 | volume= 35 | issue= 6 | pages= 1358-70 | pmid=2770114 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2770114 }}</ref> | |||
==References== | ==References== |
Revision as of 16:58, 20 December 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Ali Poyan Mehr, M.D. [2];Associate Editor(s)-in-Chief: Krzysztof Wierzbicki M.D. [3]
Overview
Laboratory Findings
Laboratory findings consistent with the diagnosis of HIV-associated nephropathy include, high-grade proteinuria, elevated serum creatinine levels, hypoalbuniemia, hyperlipidemia, CD4 counts below 200 cells/mm3, hyaline casts, leukocytes, oval fat bodies, and microhematuria. Routine laboratory tests that may be ordered to help in identify HIV-associated nephropathy are:
Blood Work-up
- Complete blood count (CBC)
- Serum creatinine
- Lipid profile
- Albumin
- ELISA
- Dot blot
- Latex agglutination test
Supplemental Test
- Western blot
- Immunofluorescence
Urinalysis
- Proteinuria
- Microhematuria
- Leukocytes
- Oval fat bodies
- Hyaline casts
Renal Biopsy
Renal biopsy is the standard in establishing a diagnosis of HIV-associated nephropathy. Renal biopsy reveals focal segmental glomerulonephritis, significant tubulointerstitial injury and microcystic tubular dilation are characteristically seen. [1]
References
- ↑ D'Agati V, Suh JI, Carbone L, Cheng JT, Appel G (1989). "Pathology of HIV-associated nephropathy: a detailed morphologic and comparative study". Kidney Int. 35 (6): 1358–70. PMID 2770114.