Congenital rubella syndrome CDC case definitions: Difference between revisions
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!Criteria | !Criteria | ||
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!Suspected | |||
|An [[infant]] who does not meet the criteria for a probable or confirmed case but who has '''one or more''' of the following findings: | |An [[infant]] who does not meet the criteria for a probable or confirmed case but who has '''one or more''' of the following findings: | ||
* [[Cataracts]] | * [[Cataracts]] | ||
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* Radiolucent [[bone disease]] | * Radiolucent [[bone disease]] | ||
|- | |- | ||
!Probable | |||
|An [[infant]] who '''does not have laboratory confirmation of [[rubella]]''' infection but has '''at least two''' of the following, without a more plausible etiology: | |An [[infant]] who '''does not have laboratory confirmation of [[rubella]]''' infection but has '''at least two''' of the following, without a more plausible etiology: | ||
* [[Cataracts]] or [[congenital]] [[glaucoma]], | * [[Cataracts]] or [[congenital]] [[glaucoma]], | ||
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* Radiolucent [[bone disease]] | * Radiolucent [[bone disease]] | ||
|- | |- | ||
!Confirmed | |||
|An [[infant]] with '''at least one''' of the symptoms clinically consistent with congenital rubella syndrome listed above; and laboratory evidence of congenital rubella infection demonstrated by: | |An [[infant]] with '''at least one''' of the symptoms clinically consistent with congenital rubella syndrome listed above; and laboratory evidence of congenital rubella infection demonstrated by: | ||
# Isolation of [[rubella virus]], '''OR''' | # Isolation of [[rubella virus]], '''OR''' | ||
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# A specimen that is [[PCR]]-positive for [[rubella virus]] | # A specimen that is [[PCR]]-positive for [[rubella virus]] | ||
|- | |- | ||
!Infection only | |||
| | |An [[infant]] '''without''' any clinical symptoms or signs of rubella but with laboratory evidence of infection demonstrated by: | ||
* Isolation of [[rubella virus]], '''OR''' | |||
* Detection of [[rubella]]-specific [[immunoglobulin M]] ([[IgM]]) [[antibody]], '''OR''' | |||
* [[Infant]] [[rubella]] [[antibody]] level that persists at a higher level and for a longer period of time than expected from passive transfer of maternal [[antibody]] (i.e., [[rubella]] [[titer]] that does not drop at the expected rate of a two-fold decline per month), '''OR''' | |||
* A specimen that is [[PCR]]-positive for [[rubella virus]] | |||
|} | |} | ||
Revision as of 16:50, 5 January 2017
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Kalsang Dolma, M.B.B.S.[2], Dima Nimri, M.D. [3]
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Congenital Rubella Syndrome Microchapters |
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Differentiating Congenital Rubella Syndrome from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Congenital rubella syndrome CDC case definitions On the Web |
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American Roentgen Ray Society Images of Congenital rubella syndrome CDC case definitions |
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Congenital rubella syndrome CDC case definitions in the news |
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Directions to Hospitals Treating Congenital rubella syndrome |
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Risk calculators and risk factors for Congenital rubella syndrome CDC case definitions |
Overview
CDC Case Definitions
in 2009, the CDC published the following case definition for case classification of congenital rubella syndrome:
| Case Classification | Criteria |
|---|---|
| Suspected | An infant who does not meet the criteria for a probable or confirmed case but who has one or more of the following findings:
|
| Probable | An infant who does not have laboratory confirmation of rubella infection but has at least two of the following, without a more plausible etiology:
OR An infant who does not have laboratory confirmation of rubella infection but has at least one or more of the following, without a more plausible etiology:
AND One or more of the following:
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| Confirmed | An infant with at least one of the symptoms clinically consistent with congenital rubella syndrome listed above; and laboratory evidence of congenital rubella infection demonstrated by:
|
| Infection only | An infant without any clinical symptoms or signs of rubella but with laboratory evidence of infection demonstrated by:
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