Amoebic liver abscess laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Yamuna Kondapally, M.B.B.S[2]

Laboratory Findings

Laboratory tests consistent with diagnosis of Amoebic liver abscess include:

Complete blood picture

• Heamoglobin <10g/dl
• Leukocytosis
• Neutrophilia

ESR and CRP

Elevated ESR and C-reactive protein

Liver function tests

• Acte infection

• Elevated aspartate aminotransferase
• Normal alkaline phosphatase

• Chronic infection

• Elevated aspartate aminotransferase
• Elevated alkaline phosphatase

Stool Examination

• Microscopic stool examination for cysts

• Microscopic stool examination for cysts is of little value due to infection with nonpathogenic strain of E dispar
• If positive it suggests the diagnosis of amoebiasis.
• Cysts must be differentiated from Entamoeba hartmanni, Endolimax nana, and Entamoeba coli.

• Examination for trophozoites

• As the trophozoites are very sensitive and may be excreted intermittently, at least three fresh specimens are taken.
• A combination of iodine-stained concentrates, trichome-stained preparations, and wet mount are used.
• Trophozoites must be differentiated with neutrophils.

• Findings suggestive of amoebic colitis include:

• Charcot-leyden crystal protein
• Positive test for heme
• A paucity of neutrophils

Stool antigen detection

• Used to differentiate E histolytica from E dispar

Blood test for amoebiasis and stool testing for amoebiasis