Cytomegalovirus infection natural history, complications and prognosis: Difference between revisions
No edit summary |
|||
| Line 14: | Line 14: | ||
*CMV encephalitis | *CMV encephalitis | ||
*CMV pneumonia | *CMV pneumonia | ||
*CMV myocarditis | |||
*Increased risk of secondary bacterial and fungal infections | *Increased risk of secondary bacterial and fungal infections | ||
Complications in critically ill immunocompetent patients include: | Complications in critically ill immunocompetent patients include: | ||
| Line 21: | Line 22: | ||
*Nosocomial infections | *Nosocomial infections | ||
*Endothelial cell dysfunction can cause portal or femoropopliteal vascular thrombosis | *Endothelial cell dysfunction can cause portal or femoropopliteal vascular thrombosis | ||
Complications of CMV infection in organ transplant patients: | |||
*Acute allograft failure and rejection | |||
*Death | |||
===Prognosis=== | ===Prognosis=== | ||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 17:47, 24 May 2017
|
Cytomegalovirus infection Microchapters |
|
Differentiating Cytomegalovirus infection from other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Case Studies |
|
Cytomegalovirus infection natural history, complications and prognosis On the Web |
|
American Roentgen Ray Society Images of Cytomegalovirus infection natural history, complications and prognosis |
|
FDA on Cytomegalovirus infection natural history, complications and prognosis |
|
CDC on Cytomegalovirus infection natural history, complications and prognosis |
|
Cytomegalovirus infection natural history, complications and prognosis in the news |
|
Blogs on Cytomegalovirus infection natural history, complications and prognosis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aravind Kuchkuntla, M.B.B.S[2]
Overview
Natural History, Complications and Prognosis
Natural History
Primary CMV infection takes place in childhood and early adolescence is asymptomatic. After the resolution of the primary infection CMV is latent in the mononuclear leukocytes. Reactivation of the virus can occur during states of stress and immunosuppression. Reactivation in immunocompetent patients presents with mononucleosis like syndrome, but severe infection presents with clinical manifestations affecting the gastrointestinal tract and the central nervous system. Retinitis and pneumonitis are uncommon in immunocompetent patients when compared to immunocompromised patients. Reactivation of CMV infection in immunocompromised patients results in CMV end organ infection affecting multiple organs.[1]
Complications
Common complications of CMV infection in immunocompromised patients include:[1]
- CMV retinitis
- CMV colitis
- CMV encephalitis
- CMV pneumonia
- CMV myocarditis
- Increased risk of secondary bacterial and fungal infections
Complications in critically ill immunocompetent patients include:
- Increased mortality rate
- Prolonged intensive care unit and hospital length of stay
- Prolonged mechanical ventilation
- Nosocomial infections
- Endothelial cell dysfunction can cause portal or femoropopliteal vascular thrombosis
Complications of CMV infection in organ transplant patients:
- Acute allograft failure and rejection
- Death
Prognosis
References
- ↑ 1.0 1.1 Al-Omari A, Aljamaan F, Alhazzani W, Salih S, Arabi Y (2016). "Cytomegalovirus infection in immunocompetent critically ill adults: literature review". Ann Intensive Care. 6 (1): 110. doi:10.1186/s13613-016-0207-8. PMC 5095093. PMID 27813024.