Cytomegalovirus infection other diagnostic studies: Difference between revisions
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==Overview== | ==Overview== | ||
Other diagnostic studies helpful for the diagnosis of CMV infection include upper GI endoscopy, colonoscopy, serology and PCR. | Other diagnostic studies helpful for the diagnosis of [[Cytomegalovirus infection|CMV infection]] include upper GI [[endoscopy]], [[colonoscopy]], [[serology]] and [[PCR]]. | ||
==Other Diagnostic Tests== | ==Other Diagnostic Tests== | ||
*Upper GI | *Upper GI [[endoscopy]] will reveal ulcers in the distal [[esophagus]] and diagnosis is confirmed by the demonstration of characteristic intranuclear [[inclusion bodies]] in the [[endothelial cells]] of the [[biopsy]] specimen. Culture of [[cytomegalovirus]] from the esophageal [[biopsy]] is not sufficient to confirm the diagnosis in the absence of microscopic findings as majority of patients with low [[CD4]] counts have positive culture. | ||
*Cytomegalovirus pneumonitis is a uncommon condition and is usually asymptomatic. It is usually diagnosed on bronchoalveolar lavage and co-exists with an underlying pulmonary infection.<ref name="urlwww.idsociety.org">{{cite web |url=https://www.idsociety.org/uploadedFiles/HIVMA/Guidelines_Patient_Care/HIVMA_Standards_Practice_Guidelines/HIV_Guidelines/Guidelines_Content/adult_oi.pdf |title=www.idsociety.org |format= |work= |accessdate=}}</ref> | *[[Cytomegalovirus]] [[pneumonitis]] is a uncommon condition and is usually asymptomatic. It is usually diagnosed on [[bronchoalveolar lavage]] and co-exists with an underlying pulmonary infection.<ref name="urlwww.idsociety.org">{{cite web |url=https://www.idsociety.org/uploadedFiles/HIVMA/Guidelines_Patient_Care/HIVMA_Standards_Practice_Guidelines/HIV_Guidelines/Guidelines_Content/adult_oi.pdf |title=www.idsociety.org |format= |work= |accessdate=}}</ref> | ||
===Microscopic Pathology=== | ===Microscopic Pathology=== | ||
*Demonstration of characteristic [[Inclusion bodies|intranuclear inclusion bodies]] in the [[biopsy]] from [[esophagus]] and [[colon]] confirms the diagnosis of [[esophagitis]] and [[colitis]].<ref name="urlwww.idsociety.org">{{cite web |url=https://www.idsociety.org/uploadedFiles/HIVMA/Guidelines_Patient_Care/HIVMA_Standards_Practice_Guidelines/HIV_Guidelines/Guidelines_Content/adult_oi.pdf |title=www.idsociety.org |format= |work= |accessdate=}}</ref> | *Demonstration of characteristic [[Inclusion bodies|intranuclear inclusion bodies]] in the [[biopsy]] from [[esophagus]] and [[colon]] confirms the diagnosis of [[esophagitis]] and [[colitis]].<ref name="urlwww.idsociety.org">{{cite web |url=https://www.idsociety.org/uploadedFiles/HIVMA/Guidelines_Patient_Care/HIVMA_Standards_Practice_Guidelines/HIV_Guidelines/Guidelines_Content/adult_oi.pdf |title=www.idsociety.org |format= |work= |accessdate=}}</ref> | ||
===CSF Analysis=== | ===CSF Analysis=== | ||
*'''CMV Encephalitis''' | *'''CMV Encephalitis''' | ||
**[[Cerebrospinal fluid]] demonstrates lymphocytic pleocytosis, low-to-normal [[glucose]] levels, and normal-to-elevated [[protein]] levels.<ref name="urlwww.idsociety.org">{{cite web |url=https://www.idsociety.org/uploadedFiles/HIVMA/Guidelines_Patient_Care/HIVMA_Standards_Practice_Guidelines/HIV_Guidelines/Guidelines_Content/adult_oi.pdf |title=www.idsociety.org |format= |work= |accessdate=}}</ref> | **[[Cerebrospinal fluid]] demonstrates lymphocytic [[pleocytosis]], low-to-normal [[glucose]] levels, and normal-to-elevated [[protein]] levels.<ref name="urlwww.idsociety.org">{{cite web |url=https://www.idsociety.org/uploadedFiles/HIVMA/Guidelines_Patient_Care/HIVMA_Standards_Practice_Guidelines/HIV_Guidelines/Guidelines_Content/adult_oi.pdf |title=www.idsociety.org |format= |work= |accessdate=}}</ref> | ||
*'''CMV polyradiculomyelopathy''' | *'''CMV polyradiculomyelopathy''' | ||
**[[Cerebrospinal fluid|Cerebrospinal fluid analysis]] demonstrates neutrophilic pleocytosis, low [[glucose]] levels and elevated [[protein]] levels.<ref name="urlwww.idsociety.org">{{cite web |url=https://www.idsociety.org/uploadedFiles/HIVMA/Guidelines_Patient_Care/HIVMA_Standards_Practice_Guidelines/HIV_Guidelines/Guidelines_Content/adult_oi.pdf |title=www.idsociety.org |format= |work= |accessdate=}}</ref> | **[[Cerebrospinal fluid|Cerebrospinal fluid analysis]] demonstrates neutrophilic [[pleocytosis]], low [[glucose]] levels and elevated [[protein]] levels.<ref name="urlwww.idsociety.org">{{cite web |url=https://www.idsociety.org/uploadedFiles/HIVMA/Guidelines_Patient_Care/HIVMA_Standards_Practice_Guidelines/HIV_Guidelines/Guidelines_Content/adult_oi.pdf |title=www.idsociety.org |format= |work= |accessdate=}}</ref> | ||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 18:09, 30 May 2017
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Cytomegalovirus infection Microchapters |
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Differentiating Cytomegalovirus infection from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Cytomegalovirus infection other diagnostic studies On the Web |
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American Roentgen Ray Society Images of Cytomegalovirus infection other diagnostic studies |
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Cytomegalovirus infection other diagnostic studies in the news |
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Risk calculators and risk factors for Cytomegalovirus infection other diagnostic studies |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aravind Kuchkuntla, M.B.B.S[2]
Overview
Other diagnostic studies helpful for the diagnosis of CMV infection include upper GI endoscopy, colonoscopy, serology and PCR.
Other Diagnostic Tests
- Upper GI endoscopy will reveal ulcers in the distal esophagus and diagnosis is confirmed by the demonstration of characteristic intranuclear inclusion bodies in the endothelial cells of the biopsy specimen. Culture of cytomegalovirus from the esophageal biopsy is not sufficient to confirm the diagnosis in the absence of microscopic findings as majority of patients with low CD4 counts have positive culture.
- Cytomegalovirus pneumonitis is a uncommon condition and is usually asymptomatic. It is usually diagnosed on bronchoalveolar lavage and co-exists with an underlying pulmonary infection.[1]
Microscopic Pathology
- Demonstration of characteristic intranuclear inclusion bodies in the biopsy from esophagus and colon confirms the diagnosis of esophagitis and colitis.[1]
CSF Analysis
- CMV Encephalitis
- Cerebrospinal fluid demonstrates lymphocytic pleocytosis, low-to-normal glucose levels, and normal-to-elevated protein levels.[1]
- CMV polyradiculomyelopathy
- Cerebrospinal fluid analysis demonstrates neutrophilic pleocytosis, low glucose levels and elevated protein levels.[1]
References
- ↑ 1.0 1.1 1.2 1.3 "www.idsociety.org" (PDF).