Graft-versus-host disease future or investigational therapies: Difference between revisions
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{{Graft-versus-host disease}} | {{Graft-versus-host disease}} | ||
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==Overview== | ==Overview== | ||
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==Future or Investigational Therapies== | ==Future or Investigational Therapies== | ||
*Regarding diagnostics, early and more sensitive diagnostic strategies are being studied. Wireless capsule endoscopy has been proposed for upper GI GvHD diagnosis.<ref name="pmid25360304">{{cite journal| author=Coron E, Laurent V, Malard F, Le Rhun M, Chevallier P, Guillaume T et al.| title=Early detection of acute graft-versus-host disease by wireless capsule endoscopy and probe-based confocal laser endomicroscopy: results of a pilot study. | journal=United European Gastroenterol J | year= 2014 | volume= 2 | issue= 3 | pages= 206-15 | pmid=25360304 | doi=10.1177/2050640614529283 | pmc=4212456 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25360304 }} </ref> A pilot study of 15 patients showed that wireless capsule endoscopy could be a novel method for early GI GvHD diagnosis. The benefits are that this procedure is less invasive that a traditional endoscopy and bypasses the potential problem of false negatives, given patchy distribution of inflammation in GI GvHD.<ref name="pmid25360304">{{cite journal| author=Coron E, Laurent V, Malard F, Le Rhun M, Chevallier P, Guillaume T et al.| title=Early detection of acute graft-versus-host disease by wireless capsule endoscopy and probe-based confocal laser endomicroscopy: results of a pilot study. | journal=United European Gastroenterol J | year= 2014 | volume= 2 | issue= 3 | pages= 206-15 | pmid=25360304 | doi=10.1177/2050640614529283 | pmc=4212456 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25360304 }} </ref> | |||
*Regarding therapeutics, there are a few medications that are currently being investigated for GvHD treatment. Such examples include ibrutinib (a Bruton's tyrosine kinase inhibitor) and ruxolitinib (a JAK2 inhibitor). These medications are not formally FDA-approved thus far, but they may become approved in the near future pending further clinical studies. | |||
There are a large number of clinical trials either ongoing or recently completed in the investigation of graft-versus-host disease treatment and prevention<ref>http://www.clinicaltrial.gov/ct2/results?term=Graft-versus-host+disease search of clinicaltrials.gov for Graft-versus-host disease]</ref>. | There are a large number of clinical trials either ongoing or recently completed in the investigation of graft-versus-host disease treatment and prevention<ref>http://www.clinicaltrial.gov/ct2/results?term=Graft-versus-host+disease search of clinicaltrials.gov for Graft-versus-host disease]</ref>. | ||
Revision as of 22:30, 15 June 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] {shyam}}
Overview
Future or Investigational Therapies
- Regarding diagnostics, early and more sensitive diagnostic strategies are being studied. Wireless capsule endoscopy has been proposed for upper GI GvHD diagnosis.[1] A pilot study of 15 patients showed that wireless capsule endoscopy could be a novel method for early GI GvHD diagnosis. The benefits are that this procedure is less invasive that a traditional endoscopy and bypasses the potential problem of false negatives, given patchy distribution of inflammation in GI GvHD.[1]
- Regarding therapeutics, there are a few medications that are currently being investigated for GvHD treatment. Such examples include ibrutinib (a Bruton's tyrosine kinase inhibitor) and ruxolitinib (a JAK2 inhibitor). These medications are not formally FDA-approved thus far, but they may become approved in the near future pending further clinical studies.
There are a large number of clinical trials either ongoing or recently completed in the investigation of graft-versus-host disease treatment and prevention[2].
References
- ↑ 1.0 1.1 Coron E, Laurent V, Malard F, Le Rhun M, Chevallier P, Guillaume T; et al. (2014). "Early detection of acute graft-versus-host disease by wireless capsule endoscopy and probe-based confocal laser endomicroscopy: results of a pilot study". United European Gastroenterol J. 2 (3): 206–15. doi:10.1177/2050640614529283. PMC 4212456. PMID 25360304.
- ↑ http://www.clinicaltrial.gov/ct2/results?term=Graft-versus-host+disease search of clinicaltrials.gov for Graft-versus-host disease]