Systemic lupus erythematosus causes: Difference between revisions

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{{CMG}}; {{AE}} {{RT}}
{{CMG}}; {{AE}} {{RT}}
==Overview==
There are no established causes for systemic lupus erythematosus. Common causes of systemic lupus erythematosus include genetic predisposition, auto-immune disease, and drugs. Less common causes of systemic lupus erythematosus include environmental factors,and exposure to ultraviolet (UV) light.


==Overview==
==Causes==
==Causes==
Despite the dramatic rise in '''lupus''' research in recent years, the exact cause of the disease remains unknown. Indeed, consensus is still lacking on whether lupus is a single condition or a group of related diseases. [[SLE]] is a chronic [[inflammation|inflammatory]] disease believed to be a [[Hypersensitivity#Type III - immune complex|type III hypersensitivity]] response with potential [[Hypersensitivity#Type 2 - antibody-dependent|type II]] involvement,<ref>[http://pathmicro.med.sc.edu/ghaffar/hyper00.htm University of South Carolina lecture on immunology]</ref> characterized by the body's production of antibodies against the nuclear components of its own cells. There are three mechanisms by which lupus is thought to develop:
* Genetic predisposition 8749564
* Genetic predisposition
** HLA class polymorphism
* Environmental triggers
** Complement genes
* Drug reaction ([[drug-induced lupus]]) - There are about 400 medications currently in use that can cause this condition, though the most common drugs are
** Female sexual gene due to high levels of estrogen and prolactin
** [[Ethosuximide]]
* Auto-immune disease  7656468
** [[Ethotoin]]
* Environmental triggers 12464374
** [[Procainamide]]
** Infections
** [[Hydralazine]]
*** Epstein-Barr virus (EBV)
** [[Quinidine]]
*** Trypanosomiasis
** [[Losartan potassium and Hydrochlorothiazide]]
*** Mycobacterial infections 
** [[Oxcarbazepine]]
** Exposure to ultraviolet (UV) light
** [[Oxytetracycline]]
*** Can exacerbate or induce systemic manifestations of SLE 
** [[Pegylated interferon alfa-2b]]
* Drug-induced lupus
**[[Dapsone]]
** Acebutolol
** [[Trimethadione]]
** Adalimumab
**[[Trientine]]
** Anastrozole
*Drugs excerbating SLE:
** Bupropion
** [[Doxycycline]]
** Captopril
** Cilazapril
** Cinnarizine/thiethylperazine
** Diltiazem
** Docetaxel
** Doxorubicin
** D-penicillamine
** Etanercept
** Gemcitabine
** Glyburide
** Golimumab
** Griseofulvin
** Hydrochlorothiazide
** Infliximab
** Interferon-alpha
** Interferon-beta
** Oxprenolol
** Phenytoin
** Lamotrigine
** Lansoprazole
** Leflunomide
** Leuprorelin
** Naproxen
** Nifedipine
** Nitrendipine
** Omeprazole
** Paclitaxel
** Pantoprazole
** Piroxicam
** Pravastatin
** Ranitidine
** Simvastatin
** Spironolactone
** Tamoxifen
** Terbinafine
** Ticlopidine
** Verapamil
** sulfonamide containing antibiotics, have been associated with SLE exacerbations and should be avoided


==References==
==References==

Revision as of 23:51, 26 June 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2]

Overview

There are no established causes for systemic lupus erythematosus. Common causes of systemic lupus erythematosus include genetic predisposition, auto-immune disease, and drugs. Less common causes of systemic lupus erythematosus include environmental factors,and exposure to ultraviolet (UV) light.

Causes

  • Genetic predisposition 8749564
    • HLA class polymorphism
    • Complement genes
    • Female sexual gene due to high levels of estrogen and prolactin
  • Auto-immune disease 7656468
  • Environmental triggers 12464374
    • Infections
      • Epstein-Barr virus (EBV)
      • Trypanosomiasis
      • Mycobacterial infections 
    • Exposure to ultraviolet (UV) light
      • Can exacerbate or induce systemic manifestations of SLE 
  • Drug-induced lupus
    • Acebutolol
    • Adalimumab
    • Anastrozole
    • Bupropion
    • Captopril
    • Cilazapril
    • Cinnarizine/thiethylperazine
    • Diltiazem
    • Docetaxel
    • Doxorubicin
    • D-penicillamine
    • Etanercept
    • Gemcitabine
    • Glyburide
    • Golimumab
    • Griseofulvin
    • Hydrochlorothiazide
    • Infliximab
    • Interferon-alpha
    • Interferon-beta
    • Oxprenolol
    • Phenytoin
    • Lamotrigine
    • Lansoprazole
    • Leflunomide
    • Leuprorelin
    • Naproxen
    • Nifedipine
    • Nitrendipine
    • Omeprazole
    • Paclitaxel
    • Pantoprazole
    • Piroxicam
    • Pravastatin
    • Ranitidine
    • Simvastatin
    • Spironolactone
    • Tamoxifen
    • Terbinafine
    • Ticlopidine
    • Verapamil
    • sulfonamide containing antibiotics, have been associated with SLE exacerbations and should be avoided

References

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