Filariasis differential diagnosis: Difference between revisions
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! Diseases | ! Diseases | ||
! colspan=" | ! colspan="7" |Symptoms | ||
! Signs | ! Signs | ||
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! | ! | ||
!History | !History | ||
!Onset | |||
!Pain | !Pain | ||
!Fever | !Fever | ||
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* History of living in endemic area or travelling to it | * History of living in endemic area or travelling to it | ||
|Chronic | |||
|<nowiki>+</nowiki> | |<nowiki>+</nowiki> | ||
| + | | + | ||
|Bilateral | |Bilateral | ||
| + | | + | ||
| | |<nowiki>-</nowiki> | ||
| | | | ||
* [[Hepatomegaly]] | * [[Hepatomegaly]] | ||
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* [[Rhonchi]] may be present in patients with Pulmonary tropical eosinophilia syndrome | * [[Rhonchi]] may be present in patients with Pulmonary tropical eosinophilia syndrome | ||
| | | | ||
==== Preparing Blood Smears | ==== Preparing Blood Smears ==== | ||
===== Thick Smears ===== | |||
Thick smears consist of a thick layer of dehemoglobinized (lysed) [[Red blood cell|red blood cells]] (RBCs).Thick smears allow a more efficient detection of parasites (increased sensitivity). | |||
===== Thick Smears | |||
Thick smears consist of a thick layer of dehemoglobinized (lysed) [[Red blood cell|red blood cells]] (RBCs). | |||
===== Thin Smears ===== | |||
Thin smears consist of [[blood]] spread in a layer such that the thickness decrease. | |||
|- | |- | ||
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* History of untreated varicose veins | * History of untreated varicose veins | ||
* Painful bilateral lower limb swelling increase with standing and decreased by rest and leg elevation | * Painful bilateral lower limb swelling increase with standing and decreased by rest and leg elevation | ||
|Chronic | |||
|<nowiki>+</nowiki> | |<nowiki>+</nowiki> | ||
| - | | - | ||
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(If congenial , Venous insufficiency un testicular veins may form scrotal swelling) | (If congenial , Venous insufficiency un testicular veins may form scrotal swelling) | ||
| | | - | ||
| | | | ||
* Typical varicose veins | * Typical varicose veins | ||
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* History of prolonged recumbency | * History of prolonged recumbency | ||
* Classic symptoms of DVT include acute unilateral swelling, pain, and erythema | * Classic symptoms of DVT include acute unilateral swelling, pain, and erythema | ||
|Acute | |||
| + | | + | ||
| - | | - | ||
|Unilateral | |Unilateral | ||
| - | | - | ||
| | |May be associated with primary disease mandates recumbency for long duration | ||
| | |Positive Homan's sign | ||
| | | | ||
* Compression ultrasonography (CUS) with Doppler is the diagnostic test of choice | * Compression ultrasonography (CUS) with Doppler is the diagnostic test of choice | ||
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|- | |- | ||
|Lipedema | |Lipedema | ||
| | |Family history especially in women; X-linked dominant or autosomal dominant condition<ref name="pmid20358611">{{cite journal| author=Child AH, Gordon KD, Sharpe P, Brice G, Ostergaard P, Jeffery S et al.| title=Lipedema: an inherited condition. | journal=Am J Med Genet A | year= 2010 | volume= 152A | issue= 4 | pages= 970-6 | pmid=20358611 | doi=10.1002/ajmg.a.33313 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20358611 }}</ref> Abnormal deposition of fat and edema | ||
|Chronic | |||
| + | | + | ||
| - | | - | ||
|Bilateral | |Bilateral | ||
| - | | - | ||
| | |<nowiki>-</nowiki> | ||
|Tender with palpation | |||
| | | | ||
|- | |- | ||
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* History of untreated hypothyroidism | * History of untreated hypothyroidism | ||
* Infiltration of the skin with glycosaminoglycans with associated water retention | * Infiltration of the skin with glycosaminoglycans with associated water retention | ||
|Chronic | |||
| + | | + | ||
| - | | - | ||
|Bilateral | |Bilateral | ||
| - | | - | ||
| | | + | ||
(hypothyroidism ) | |||
| | | | ||
| | | | ||
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|Cellulitis | |Cellulitis | ||
|Acute painful swelling and may be fever | |Acute painful swelling and may be fever | ||
|Acute | |||
| + | | + | ||
| + | | + | ||
|Unilateral | |Unilateral | ||
| - | | - | ||
| | | - | ||
|Tenderness,hotness and may be flactuation if abscess formed | |Tenderness,hotness and may be flactuation if abscess formed | ||
| | | | ||
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|Other causes of generalized edema | |Other causes of generalized edema | ||
|History of chronic general condition(cardiac-liver-renal) | |History of chronic general condition(cardiac-liver-renal) | ||
|Chronic | |||
| - | | - | ||
| - | | - | ||
|Bilateral | |Bilateral | ||
| - | | - | ||
| | |<nowiki>+</nowiki> | ||
| | | | ||
| | | | ||
|- | |- | ||
| colspan=" | | colspan="10" | | ||
|} | |} | ||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Revision as of 13:46, 30 June 2017
|
Filariasis Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Filariasis differential diagnosis On the Web |
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American Roentgen Ray Society Images of Filariasis differential diagnosis |
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Risk calculators and risk factors for Filariasis differential diagnosis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Mohammed Abdelwahed M.D[2]
|
Filariasis Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Filariasis differential diagnosis On the Web |
|
American Roentgen Ray Society Images of Filariasis differential diagnosis |
|
Risk calculators and risk factors for Filariasis differential diagnosis |
Overview
Lymphatic filariasis must be differentiated from other causes of lower limb edema, such as chronic venous insufficiency, acute deep venous thrombosis, lipedema, myxedema, cellulitis and causes of generalized edema. Hydrocele sholud be differentiated from other causes of testicular masses. Breast lymphedema must be differentiated from breast cancer.
Differentiating filariasis from other diseases
| Diseases | Symptoms | Signs | Investigations | ||||||
|---|---|---|---|---|---|---|---|---|---|
| History | Onset | Pain | Fever | Laterality | Scrotal swelling | Symptoms of primary disease | |||
| Lymphatic filariasis |
|
Chronic | + | + | Bilateral | + | - |
|
Preparing Blood SmearsThick SmearsThick smears consist of a thick layer of dehemoglobinized (lysed) red blood cells (RBCs).Thick smears allow a more efficient detection of parasites (increased sensitivity). Thin SmearsThin smears consist of blood spread in a layer such that the thickness decrease.
|
| Chronic venous insufficiency |
|
Chronic | + | - | Bilateral | +
(If congenial , Venous insufficiency un testicular veins may form scrotal swelling) |
- |
|
Duplex ultrasound will demonstrate typical findings of venous valvular insufficiency |
| Acute deep venous thrombosis |
|
Acute | + | - | Unilateral | - | May be associated with primary disease mandates recumbency for long duration | Positive Homan's sign |
|
| Lipedema | Family history especially in women; X-linked dominant or autosomal dominant condition[1] Abnormal deposition of fat and edema | Chronic | + | - | Bilateral | - | - | Tender with palpation | |
| Myxedema |
|
Chronic | + | - | Bilateral | - | +
(hypothyroidism ) |
||
| Cellulitis | Acute painful swelling and may be fever | Acute | + | + | Unilateral | - | - | Tenderness,hotness and may be flactuation if abscess formed | |
| Other causes of generalized edema | History of chronic general condition(cardiac-liver-renal) | Chronic | - | - | Bilateral | - | + | ||
References
- ↑ Child AH, Gordon KD, Sharpe P, Brice G, Ostergaard P, Jeffery S; et al. (2010). "Lipedema: an inherited condition". Am J Med Genet A. 152A (4): 970–6. doi:10.1002/ajmg.a.33313. PMID 20358611.