Systemic lupus erythematosus causes: Difference between revisions
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==Causes== | ==Causes== | ||
* Genetic predisposition | * Genetic predisposition<ref name="pmid8749564">{{cite journal |vauthors=Schur PH |title=Genetics of systemic lupus erythematosus |journal=Lupus |volume=4 |issue=6 |pages=425–37 |year=1995 |pmid=8749564 |doi=10.1177/096120339500400603 |url=}}</ref> | ||
** [[HLA]] class polymorphism | ** [[HLA]] class polymorphism | ||
** [[Complement]] genes | ** [[Complement]] genes | ||
** Female sexual gene due to high levels of [[estrogen]] and [[prolactin]] | ** Female sexual gene due to high levels of [[estrogen]] and [[prolactin]] | ||
* [[Auto-immune]] disease | * [[Auto-immune]] disease<ref name="pmid7656468">{{cite journal |vauthors=Cutolo M, Sulli A, Seriolo B, Accardo S, Masi AT |title=Estrogens, the immune response and autoimmunity |journal=Clin. Exp. Rheumatol. |volume=13 |issue=2 |pages=217–26 |year=1995 |pmid=7656468 |doi= |url=}}</ref> | ||
* Environmental triggers 12464374 | * Environmental triggers<ref name="pmid12464374">{{cite journal |vauthors=Cooper GS, Dooley MA, Treadwell EL, St Clair EW, Gilkeson GS |title=Risk factors for development of systemic lupus erythematosus: allergies, infections, and family history |journal=J Clin Epidemiol |volume=55 |issue=10 |pages=982–9 |year=2002 |pmid=12464374 |doi= |url=}}</ref> | ||
** Infections | ** Infections | ||
*** [[Epstein-Barr virus|Epstein-Barr virus (EBV)]] | *** [[Epstein-Barr virus|Epstein-Barr virus (EBV)]] | ||
Revision as of 14:48, 30 June 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2]
Overview
There are no established causes for systemic lupus erythematosus. Common causes of systemic lupus erythematosus include genetic predisposition, auto-immune disease, and drugs. Less common causes of systemic lupus erythematosus include environmental factors,and exposure to ultraviolet (UV) light.
Causes
- Genetic predisposition[1]
- HLA class polymorphism
- Complement genes
- Female sexual gene due to high levels of estrogen and prolactin
- Auto-immune disease[2]
- Environmental triggers[3]
- Infections
- Exposure to ultraviolet (UV) light
- Can exacerbate or induce systemic manifestations of SLE
- Drug-induced lupus
- Acebutolol
- Adalimumab
- Anastrozole
- Bupropion
- Captopril
- Cilazapril
- Cinnarizine/thiethylperazine
- Diltiazem
- Docetaxel
- Doxorubicin
- D-penicillamine
- Etanercept
- Gemcitabine
- Glyburide
- Golimumab
- Griseofulvin
- Hydrochlorothiazide
- Infliximab
- Interferon-alpha
- Interferon-beta
- Oxprenolol
- Phenytoin
- Lamotrigine
- Lansoprazole
- Leflunomide
- Leuprorelin
- Naproxen
- Nifedipine
- Nitrendipine
- Omeprazole
- Paclitaxel
- Pantoprazole
- Piroxicam
- Pravastatin
- Ranitidine
- Simvastatin
- Spironolactone
- Tamoxifen
- Terbinafine
- Ticlopidine
- Verapamil
- sulfonamide containing antibiotics, have been associated with SLE exacerbations and should be avoided
References
- ↑ Schur PH (1995). "Genetics of systemic lupus erythematosus". Lupus. 4 (6): 425–37. doi:10.1177/096120339500400603. PMID 8749564.
- ↑ Cutolo M, Sulli A, Seriolo B, Accardo S, Masi AT (1995). "Estrogens, the immune response and autoimmunity". Clin. Exp. Rheumatol. 13 (2): 217–26. PMID 7656468.
- ↑ Cooper GS, Dooley MA, Treadwell EL, St Clair EW, Gilkeson GS (2002). "Risk factors for development of systemic lupus erythematosus: allergies, infections, and family history". J Clin Epidemiol. 55 (10): 982–9. PMID 12464374.