Systemic lupus erythematosus causes: Difference between revisions
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Revision as of 16:24, 11 July 2017
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Systemic lupus erythematosus Microchapters |
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Differentiating Systemic lupus erythematosus from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2]
Overview
There are no established causes for systemic lupus erythematosus. Common causes of systemic lupus erythematosus include genetic predisposition, auto-immune diseases, and drugs. Less common causes of systemic lupus erythematosus include environmental factors and exposure to ultraviolet (UV) light.
Causes
- Genetic predisposition[1]
- HLA class polymorphism
- Complement genes
- Female sexual gene due to high levels of estrogen and prolactin
- Auto-immune disease[2]
- Environmental triggers[3]
- Exposure to ultraviolet (UV) light
- Can exacerbate or induce systemic manifestations of SLE
- Drug-induced lupus
References
- ↑ Schur PH (1995). "Genetics of systemic lupus erythematosus". Lupus. 4 (6): 425–37. doi:10.1177/096120339500400603. PMID 8749564.
- ↑ Cutolo M, Sulli A, Seriolo B, Accardo S, Masi AT (1995). "Estrogens, the immune response and autoimmunity". Clin. Exp. Rheumatol. 13 (2): 217–26. PMID 7656468.
- ↑ Cooper GS, Dooley MA, Treadwell EL, St Clair EW, Gilkeson GS (2002). "Risk factors for development of systemic lupus erythematosus: allergies, infections, and family history". J Clin Epidemiol. 55 (10): 982–9. PMID 12464374.