Growth hormone deficiency MRI: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Growth hormone deficiency}} | {{Growth hormone deficiency}} | ||
{{CMG}}; {{AE}} {MAD}} | {{CMG}}; {{AE}}<nowiki> {MAD}}</nowiki> | ||
==Overview== | ==Overview== | ||
==MRI== | ==MRI== | ||
* | *Brain MRI may be helpful in the diagnosis of growth hormone deficiency. Findings on MRI include: | ||
*MRI is highly sensitive to visualize the hypothalamo-hypophyseal tract. After the clinical and biochemical diagnosis of GHD is made | *MRI is highly sensitive to visualize the hypothalamo-hypophyseal tract. After the clinical and biochemical diagnosis of GHD is made.<ref name="pmid11095419">{{cite journal| author=Growth Hormone Research Society| title=Consensus guidelines for the diagnosis and treatment of growth hormone (GH) deficiency in childhood and adolescence: summary statement of the GH Research Society. GH Research Society. | journal=J Clin Endocrinol Metab | year= 2000 | volume= 85 | issue= 11 | pages= 3990-3 | pmid=11095419 | doi=10.1210/jcem.85.11.6984 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11095419 }}</ref> | ||
* On T1-weighted imaging, a clear demarcation can be made between the adenohypophysis (after two months of age) and the neurohypophysis, which appears as hyperintense | * On T1-weighted imaging, a clear demarcation can be made between the adenohypophysis (after two months of age) and the neurohypophysis, which appears as hyperintense.<ref name="pmid7484625">{{cite journal| author=Dietrich RB, Lis LE, Greensite FS, Pitt D| title=Normal MR appearance of the pituitary gland in the first 2 years of life. | journal=AJNR Am J Neuroradiol | year= 1995 | volume= 16 | issue= 7 | pages= 1413-9 | pmid=7484625 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7484625 }}</ref> | ||
* This imaging is important to exclude the possibility of a pituitary tumor; it also permits diagnostic characterization by showing the presence or absence of morphological abnormalities such as anterior pituitary hypoplasia, pituitary stalk agenesis, and posterior pituitary ectopia. | * This imaging is important to exclude the possibility of a pituitary tumor; it also permits diagnostic characterization by showing the presence or absence of morphological abnormalities such as anterior pituitary hypoplasia, pituitary stalk agenesis, and posterior pituitary ectopia. | ||
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* MRI may also provide evidence of severe GHD | * MRI may also provide evidence of severe GHD | ||
*The diagnosis of pituitary stalk interruption syndrome (PSIS) is made | *The diagnosis of pituitary stalk interruption syndrome (PSIS) is made.<ref name="pmid10199773">{{cite journal| author=Maghnie M, Strigazzi C, Tinelli C, Autelli M, Cisternino M, Loche S et al.| title=Growth hormone (GH) deficiency (GHD) of childhood onset: reassessment of GH status and evaluation of the predictive criteria for permanent GHD in young adults. | journal=J Clin Endocrinol Metab | year= 1999 | volume= 84 | issue= 4 | pages= 1324-8 | pmid=10199773 | doi=10.1210/jcem.84.4.5614 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10199773 }}</ref> | ||
[[File:Ectopic-posterior-pituitary.jpg|center|500px|thumb|Case courtesy of A.Prof Frank Gaillard, Radiopaedia.org, rID: 16814]] | [[File:Ectopic-posterior-pituitary.jpg|center|500px|thumb|Case courtesy of A.Prof Frank Gaillard, Radiopaedia.org, rID: 16814]] | ||
Revision as of 20:51, 16 August 2017
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Growth hormone deficiency Microchapters |
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Risk calculators and risk factors for Growth hormone deficiency MRI |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: {MAD}}
Overview
MRI
- Brain MRI may be helpful in the diagnosis of growth hormone deficiency. Findings on MRI include:
- MRI is highly sensitive to visualize the hypothalamo-hypophyseal tract. After the clinical and biochemical diagnosis of GHD is made.[1]
- On T1-weighted imaging, a clear demarcation can be made between the adenohypophysis (after two months of age) and the neurohypophysis, which appears as hyperintense.[2]
- This imaging is important to exclude the possibility of a pituitary tumor; it also permits diagnostic characterization by showing the presence or absence of morphological abnormalities such as anterior pituitary hypoplasia, pituitary stalk agenesis, and posterior pituitary ectopia.
- MRI may also provide evidence of severe GHD
- The diagnosis of pituitary stalk interruption syndrome (PSIS) is made.[3]
References
- ↑ Growth Hormone Research Society (2000). "Consensus guidelines for the diagnosis and treatment of growth hormone (GH) deficiency in childhood and adolescence: summary statement of the GH Research Society. GH Research Society". J Clin Endocrinol Metab. 85 (11): 3990–3. doi:10.1210/jcem.85.11.6984. PMID 11095419.
- ↑ Dietrich RB, Lis LE, Greensite FS, Pitt D (1995). "Normal MR appearance of the pituitary gland in the first 2 years of life". AJNR Am J Neuroradiol. 16 (7): 1413–9. PMID 7484625.
- ↑ Maghnie M, Strigazzi C, Tinelli C, Autelli M, Cisternino M, Loche S; et al. (1999). "Growth hormone (GH) deficiency (GHD) of childhood onset: reassessment of GH status and evaluation of the predictive criteria for permanent GHD in young adults". J Clin Endocrinol Metab. 84 (4): 1324–8. doi:10.1210/jcem.84.4.5614. PMID 10199773.