Insulinoma laboratory tests: Difference between revisions
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** S. C-Peptide >200 pmol/L | ** S. C-Peptide >200 pmol/L | ||
** S. proinsulin ≥ 22 pmol/L | ** S. proinsulin ≥ 22 pmol/L | ||
*Patients with insulinoma may have elevated insulin to glucose ratio >0.4, which is usually suggestive of insulinoma after a 72-hour fast test.It is a gold standard test. | *Patients with insulinoma may have elevated insulin to glucose ratio >0.4, which is usually suggestive of insulinoma after a 72-hour fast test.It is a gold standard test.<ref name="pmid18672144">{{cite journal| author=Callender GG, Rich TA, Perrier ND| title=Multiple endocrine neoplasia syndromes. | journal=Surg Clin North Am | year= 2008 | volume= 88 | issue= 4 | pages= 863-95, viii | pmid=18672144 | doi=10.1016/j.suc.2008.05.001 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18672144 }} </ref> | ||
**1/3rd or 33% patients have clinical symptoms with in 12 | **1/3rd or 33% patients have clinical symptoms with in 12 hours of the fasting. | ||
**80% develop within 24 hours | **80% develop within 24 hours | ||
**90% develop within 48 hours | **90% develop within 48 hours | ||
Revision as of 20:35, 17 August 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]
Overview
An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name].
OR
Laboratory findings consistent with the diagnosis of [disease name] include [abnormal test 1], [abnormal test 2], and [abnormal test 3].
OR
[Test] is usually normal among patients with [disease name].
OR
Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].
OR
There are no diagnostic laboratory findings associated with [disease name].
Laboratory Findings
- Laboratory findings consistent with the diagnosis of insulinoma include
- S. glucose <50 mg/dL
- S. Insulin >5-10 μU/mL
- S. C-Peptide >200 pmol/L
- S. proinsulin ≥ 22 pmol/L
- Patients with insulinoma may have elevated insulin to glucose ratio >0.4, which is usually suggestive of insulinoma after a 72-hour fast test.It is a gold standard test.[1]
- 1/3rd or 33% patients have clinical symptoms with in 12 hours of the fasting.
- 80% develop within 24 hours
- 90% develop within 48 hours
- 100% develop within 72 hours
References
- ↑ Callender GG, Rich TA, Perrier ND (2008). "Multiple endocrine neoplasia syndromes". Surg Clin North Am. 88 (4): 863–95, viii. doi:10.1016/j.suc.2008.05.001. PMID 18672144.