Cretinism causes: Difference between revisions
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**Iodine deficiency | **Iodine deficiency | ||
**Inability to uptake iodide | **Inability to uptake iodide | ||
=== Secondary (central) hypothyroidism === | |||
Central hypothyroidism is caused by:<ref name="pmid14671180">{{cite journal| author=Kempers MJ, van Tijn DA, van Trotsenburg AS, de Vijlder JJ, Wiedijk BM, Vulsma T| title=Central congenital hypothyroidism due to gestational hyperthyroidism: detection where prevention failed. | journal=J Clin Endocrinol Metab | year= 2003 | volume= 88 | issue= 12 | pages= 5851-7 | pmid=14671180 | doi=10.1210/jc.2003-030665 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=14671180 }}</ref> | |||
* Inflammation or infection of pituitary gland and hypothalamus | |||
* Trauma | |||
* Structural changes | |||
* Untreated maternal hyperthyroidism during pregnancy | |||
===Genetic Causes=== | ===Genetic Causes=== | ||
Revision as of 15:56, 21 August 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Cretinism may be caused by [cause1], [cause2], or [cause3].
Causes
Primary cretinism
Common Causes
Primary Cretinism may be caused by:[1][2]
- Congenital causes:
- Thyroid dysgenesis
- Thyroid dyshormonogenesis
- Ectopic thyroid
- Acquired causes:
- Autoimmune diseases
- Antibodies pass placenta cause hypothyroidism
- Antithyroid medications usage that can cross the placenta
- Iodine deficiency
- Inability to uptake iodide
Secondary (central) hypothyroidism
Central hypothyroidism is caused by:[3]
- Inflammation or infection of pituitary gland and hypothalamus
- Trauma
- Structural changes
- Untreated maternal hyperthyroidism during pregnancy
Genetic Causes
- Cretinism is caused by a mutation in the TTF-2 gene.
- Cretinism is caused by a mutation in the genes responsible for the thyroid hormone secretion. These genes include the following:[4][5]
- Dual oxidase 2 gene (DUOX 2)
- Thyroglobulin gene (TG)
- Thyroid peroxidase (gene (TPO)
- Thyroid stimulating hormone receptor gene (TSHR)
Causes in Alphabetical Order
List the causes of the disease in alphabetical order.
The unnamed parameter 2= is no longer supported. Please see the documentation for {{columns-list}}.
3References
- ↑ Persani L, Calebiro D, Cordella D, Weber G, Gelmini G, Libri D; et al. (2010). "Genetics and phenomics of hypothyroidism due to TSH resistance". Mol Cell Endocrinol. 322 (1–2): 72–82. doi:10.1016/j.mce.2010.01.008. PMID 20083154.
- ↑ Wassner AJ (2017). "Pediatric Hypothyroidism: Diagnosis and Treatment". Paediatr Drugs. 19 (4): 291–301. doi:10.1007/s40272-017-0238-0. PMID 28534114.
- ↑ Kempers MJ, van Tijn DA, van Trotsenburg AS, de Vijlder JJ, Wiedijk BM, Vulsma T (2003). "Central congenital hypothyroidism due to gestational hyperthyroidism: detection where prevention failed". J Clin Endocrinol Metab. 88 (12): 5851–7. doi:10.1210/jc.2003-030665. PMID 14671180.
- ↑ Narumi S, Muroya K, Asakura Y, Aachi M, Hasegawa T (2011). "Molecular basis of thyroid dyshormonogenesis: genetic screening in population-based Japanese patients". J Clin Endocrinol Metab. 96 (11): E1838–42. doi:10.1210/jc.2011-1573. PMID 21900383.
- ↑ Ohye H, Fukata S, Hishinuma A, Kudo T, Nishihara E, Ito M; et al. (2008). "A novel homozygous missense mutation of the dual oxidase 2 (DUOX2) gene in an adult patient with large goiter". Thyroid. 18 (5): 561–6. doi:10.1089/thy.2007.0258. PMID 18426362.