Hyperparathyroidism laboratory findings: Difference between revisions

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{{Hyperparathyroidism}}
{{Hyperparathyroidism}}
{{CMG}}
{{CMG}}; {{AE}}  


==Overview==
==Overview==
An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name].


==Laboratory Findings==
OR
===Serum Calcium===
 
In cases of [[primary hyperparathyroidism|primary]], [[tertiary hyperparathyroidism|tertiary]] and quintary hyperparathyroidism increased PTH consequently leads to increased serum calcium ([[hypercalcemia]]) due to:
Laboratory findings consistent with the diagnosis of [disease name] include [abnormal test 1], [abnormal test 2], and [abnormal test 3].
#increased bone resorption, allowing flow of calcium from bone to blood
 
#reduced renal clearance of calcium
OR
#increased intestinal calcium absorption
 
[Test] is usually normal among patients with [disease name].
 
OR


By contrast, in [[secondary hyperparathyroidism|secondary]] and quartary hyperparathyroidism effectiveness of [[parathyroid hormone|PTH]]is reduced.
Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].


===Serum Phosphorus===
OR
In [[primary hyperparathyroidism]], serum phosphorus levels are abnormally low as a result of decreased renal tubular phosphorus reabsorption. This contrasts with [[secondary hyperparathyroidism]], in which serum phosphorus levels are generally elevated because of renal disease.


===Alkaline Phosphatase===
There are no diagnostic laboratory findings associated with [disease name].
[[Alkaline phosphatase]] levels are elevated in all types of hyperparathyroidism.


==Diagnosis==
==Laboratory Findings==
The gold standard of diagnosis is the PTH immunoassay. Once an elevated PTH has been confirmed, goal of diagnosis is to determine whether the hyperparathyroidism is primary or secondary in origin by obtaining a serum [[calcium]] level:


{| class="wikitable"
*There are no diagnostic laboratory findings associated with [disease name].
| '''PTH''' || '''serum [[calcium]]''' || '''likely type'''
OR
|-
*An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name].
| high || high || [[primary hyperparathyroidism]]
*[Test] is usually normal among patients with [disease name].
|-
*Laboratory findings consistent with the diagnosis of [disease name] include
| high || low or normal || [[secondary hyperparathyroidism]]
**[Abnormal test 1]
|}
**[Abnormal test 2]
**[Abnormal test 3]


[[Tertiary hyperparathyroidism]] has a high PTH and a high serum calcium.  It is differentiated from primary hyperparathyroidism by a history of [[chronic kidney failure]] and [[secondary hyperparathyroidism]].
*Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].


==References==
==References==
{{Reflist|2}}


{{Reflist|2}}
{{WH}}
[[Category:Parathyroid disorders]]
{{WS}}
[[Category:Endocrinology]]

Revision as of 14:59, 24 August 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name].

OR

Laboratory findings consistent with the diagnosis of [disease name] include [abnormal test 1], [abnormal test 2], and [abnormal test 3].

OR

[Test] is usually normal among patients with [disease name].

OR

Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].

OR

There are no diagnostic laboratory findings associated with [disease name].

Laboratory Findings

  • There are no diagnostic laboratory findings associated with [disease name].

OR

  • An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name].
  • [Test] is usually normal among patients with [disease name].
  • Laboratory findings consistent with the diagnosis of [disease name] include
    • [Abnormal test 1]
    • [Abnormal test 2]
    • [Abnormal test 3]
  • Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].

References

Template:WH Template:WS