Hyperparathyroidism laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name].

OR

Laboratory findings consistent with the diagnosis of [disease name] include [abnormal test 1], [abnormal test 2], and [abnormal test 3].

OR

[Test] is usually normal among patients with [disease name].

OR

Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].

OR

There are no diagnostic laboratory findings associated with [disease name].

Laboratory Findings

Primary hyperparathyroidism

• An elevated serum ionized calcium on routine biochemical screening in a asymptomatic patient should raise the suspicion of primary hyperparathyroidism.
• An elevated/ concentration of serum ionized calcium with elevated parathyroid level is diagnostic of primary hyperparathyoidism.
• [Test] is usually normal among patients with [disease name].
• Laboratory findings consistent with the diagnosis of primary hyperparathyroidism include
  • Elevated/ concentration of serum ionized calcium
  • Elevated parathyroid level
  • [Abnormal test 3]

• Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].

Secondary hyperparathyroidism

• Laboratory findings consistent with the diagnosis of secondary hyperparathyroidism include:
  • Elevated serum parathyroid hormone level
  • Low to normal serum ionized calcium
  • Low serum vitamin D (25-hydroxy vitamin D) may be found if vitamin D deficiency is the cause of secondary hyperparathyroidism.

Tertiary hyperparathyroidism

• An elevated/ concentration of serum ionized calcium with elevated parathyroid level in post renal transplant patients is diagnostic of tertiary hyperparathyoidism.