Hypoaldosteronism classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

Hypoaldosteronism may be classified into two categories depending on the level of plasma renin and depending on the level of aldosterone into hyporeninemic hypoaldosteronism or hyperreninemic hypoaldosteronism, and aldosterone deficiency or aldosterone resistance.

(Renin deficiency is the most common cause of hypoaldosteronism).

Classification

Hypoaldosteronism may be classified into two categories depending on the level of plasma renin and depending on the level of aldosterone into hyporeninemic hypoaldosteronism or hyperreninemic hypoaldosteronism, and aldosterone deficiency or aldosterone resistance.

Based on the level of plasma renin

Hypoaldosteronism

Hyporeninemic Hypoaldosteronism

Hyperreninemic Hypoaldosteronism

•Renal insufficiency •Diabetic nephropathy •Sickle cell disease

•Addison's disease • Any severe illness such as malignancy or sepsis

Based on the level of aldosterone

Hypoaldosteronism

Aldosterone deficiency

Aldosterone resistance

•Renal insufficiency •Adrenal insufficiency • Diabetic nephropathy •Sickle cell disease •Critical illness •Congenital isolated hypoaldosteronism • Drugs such as ACEi, ARBs and Heparin

• Pseudohypoaldosteronism type 1 • Aldosterone antagonists • Epithelial sodium channel blockers • Calcineurin inhibitors